Developmental Mechanism - Cell Migration: Difference between revisions

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==Introduction==
==Introduction==
 
[[File:Chicken-gastrulation2.jpg|thumb|300px|Gastrulation epithelial to mesenchymal transition]]
The process of cell migration occurs at different stages throughout embryonic development and involves other developmental mechanisms. The first key migration occurs during [[Gastrulation]].
The process of cell migration occurs at different stages throughout embryonic development and involves other developmental mechanisms. The first key migration occurs during [[Gastrulation]].



Revision as of 13:28, 6 September 2016

Embryology - 28 Mar 2024    Facebook link Pinterest link Twitter link  Expand to Translate  
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Introduction

Gastrulation epithelial to mesenchymal transition

The process of cell migration occurs at different stages throughout embryonic development and involves other developmental mechanisms. The first key migration occurs during Gastrulation.


Mechanism - "a process, technique, or system for achieving a result".


Mechanism Links: mitosis | cell migration | cell junctions |epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular

Some Recent Findings

  • LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development[1]

"Head development in vertebrates proceeds through a series of elaborate patterning mechanisms and cell-cell interactions involving cephalic neural crest cells (CNCC). These cells undergo extensive migration along stereotypical paths after their separation from the dorsal margins of the neural tube and they give rise to most of the craniofacial skeleton. Here, we report that the silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory CNCC from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects. We further show that LKB1-mediated effects on the development of CNCC involve the sequential activation of the AMP-activated protein kinase (AMPK), the Rho-dependent kinase (ROCK) and the actin-based motor protein myosin II. Collectively, these results establish that the complex morphogenetic processes governing head formation critically depends on the activation of the LKB1 signaling network in CNCC."

  • Review - Collective cell migration in development[2] "During embryonic development, tissues undergo major rearrangements that lead to germ layer positioning, patterning, and organ morphogenesis. Often these morphogenetic movements are accomplished by the coordinated and cooperative migration of the constituent cells, referred to as collective cell migration. The molecular and biomechanical mechanisms underlying collective migration of developing tissues have been investigated in a variety of models, including border cell migration, tracheal branching, blood vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mesendoderm. Here we review recent advances in understanding collective migration in these developmental models, focusing on the interaction between cells and guidance cues presented by the microenvironment and on the role of cell-cell adhesion in mechanical and behavioral coupling of cells within the collective."
More recent papers  
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Search term: Developmental Cell Migration

<pubmed limit=5>Developmental Cell Migration</pubmed>

Search term: Neural Crest Cell Migration

<pubmed limit=5>Neural Crest Cell Migration</pubmed>

Neural Crest Development

Links: Neural Crest Development

References

  1. <pubmed>27527806</pubmed>
  2. <pubmed>26783298</pubmed>


Textbooks

Reviews

<pubmed></pubmed> <pubmed></pubmed> <pubmed>26783298</pubmed> <pubmed>25733144</pubmed> <pubmed>19914236</pubmed>

Articles

<pubmed></pubmed> <pubmed></pubmed> <pubmed>25541234</pubmed> <pubmed></pubmed>

Search PubMed

Search Pubmed: Epithelial Mesenchymal Interaction

External Links

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Mechanism Links: mitosis | cell migration | cell junctions |epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular


Glossary Links

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Cite this page: Hill, M.A. (2024, March 28) Embryology Developmental Mechanism - Cell Migration. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Cell_Migration

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G