Developmental Mechanism - Cell Junctions

Embryology - 23 Apr 2024 Expand to Translate
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Introduction

Many developmental mechanisms require dynamic changes in cell adhesion that acts through different types of cell junctions.

Adhesion Cartoons

Tight junction
Adherens Junction
Desmosome
Gap Junction

Adhesion EM Images

GIT epithelia EM1
GIT epithelia EM2
GIT epithelia EM3
Desmosome EM

Adhesion EM Images: GIT epithelia EM1 | GIT epithelia EM2 | GIT epithelia EM3 | Desmosome EM

Adhesion Cartoons: Tight junction | Adherens Junction | Desmosome | Gap Junction

Some Recent Findings

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Developmental Tight Junction \| Developmental Desmosome \| Developmental Gap Junction \| Developmental Adherens Junction

Older papers
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table. See also the Discussion Page for other references listed by year and References on this current page.

Tight Junction

Discovered by M.G. Farquhar and G.E. Palade in 1963
zonula occludens
Fusion of 2 plasma membranes acts as a “seal”
Epithelia lining
digestive system gut, ducts, cavities of glands, liver, pancreas capillary walls urinary bladder

Tight Junction

Search PubMed: Tight Junction

Adherens Junction

actin microfilaments anchor the plaque that occurs under the membrane of each cell
plaques not as dense also occur as hemi-form
heart muscle, layers covering body organs, digestive tract
transmembrane proteins
Cadherin
clustered as focal adhesion

Cadherin isoform naming was based upon the site of original identification: P-cadherin (placenta cadherin, cadherin 3), E-cadherin (epithelial cadherin cadherin 1), N-cadherin (neural cadherin, cadherin 2).

Adherens Junction

image - blood–testis barrier

Search PubMed: Adherens Junction

Desmosome

Discovered by K.R. Porter in 1954 ^[1]
intermediate filaments anchor the dense plaque that occurs under the membrane of each cell
desmos = bond
skin, lining of internal body cavity surfaces
disappear when cells are transformed

Desmosome

Search PubMed: Desmosome

Gap Junction

Discovered by J.P. Revel & M.J. Karnovsky in 1967
allowing direct communication between cells (open & close)
close membranes 2 - 3 nm apart
connexins form hollow 1.5 nm diameter cylinders
heart muscle, smooth muscle electrical and chemical integration as a single functional unit
Also in embryonic development (see blastocyst)

Gap Junction

Search PubMed: gap junction

References

↑ PORTER KR. (1954). Electron microscopy of basophilic components of cytoplasm. J. Histochem. Cytochem. , 2, 346-75. PMID: 13192325 DOI.

Reviews

Articles

External Links

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Cite this page: Hill, M.A. (2024, April 23) Embryology Developmental Mechanism - Cell Junctions. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Cell_Junctions

What Links Here?

[PMID13192325-1] PORTER KR. (1954). Electron microscopy of basophilic components of cytoplasm. J. Histochem. Cytochem. , 2, 346-75. PMID: 13192325 DOI.

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