Category:Carnegie Stage 13

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Carnegie Stage 13

This Embryology category shows pages and media related to embryonic development in week 4 to week 5, 28 - 32 days, GA week 6-7. The embryos have a crown rump length (CRL) of 4 - 6 mm and somite number 30 pairs.


There is also a specific Carnegie stage 13 resource page. See also Carnegie Stage 13 - Events

Stage 13 Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Movies | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 13 | Next Stage 14
  Historic Papers: 1905 Embryo 148 | 1926 Precervical Sinus | 1945 | 1955


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Carnegie Collection Embryos - Stage 13 
Serial No. Size (mm) Grade Fixative Embedding Medium Plane Thinness (µm) Stain Year Notes
1 E.,4.5 Ch., 30x30 Poor Salicylic acid P Transverse 10 Hemat. 1887 Obtained by Mall while student
19 E., 5.5 Ch., 18x14 Poor p ? Transverse 20 Al. coch. 1895
98 E., 4 Ch., 24x16x9 Poor p P Transverse 20 Al. coch. 1896
76 E., 4.5 Ch., 22x20 Poor Alc. P Transverse 20 Al. coch. 1897
112 E., 4 Poor p P Sagittal 10 Al. coch. p
116 E., 5 Poor p ? Sagittal 10 Al. coch. 1898
148 E.,4.3 Ch., 17x14x10 Poor Alc. P Coronal 10 (Stain - Haematoxylin Eosin) 1899 Abnormal. Nasal discs fused
186 E.,3.5 Ch., 25x20x15 Poor Alc. P Transverse 20 Al. coch. 1901
239 E., 3.0 Poor Formol P Transverse 10 (Stain - Haematoxylin Eosin) 1903
248 E., 4.5 Ch., 30x23x15 Poor p ? Coronal 50 Al. coch. 1904
407 E.,4 Ch., 14x13X7 Poor Formol ? Transverse 40 Al. coch. 1907
463 E., 3.9 Ch., 17x12x7 Good Formol P Coronal 10 Al. coch. 1910
523 E., 5 Ch., 25x25x15 Fair Formol P Transverse p Al. coch. 1911
588 E., 4.0 Ch., 19x15x8 Good Corros. acetic P Coronal 15 (Stain - Haematoxylin Eosin) 1912 Advanced
786 E., 4.5 Ch., 19x10x10 Poor Alc. P Sagittal 15 Al. coch. 1913
800 E., 6.0 Good Corros. acetic P Transverse 10 H 1913 Curettage. Anencephaly
808 E.,4.0 Poor Corros. acetic P Transverse 15 Al. coch. 1914 Tubal Incomplete
826 E., 5.0 Ch., 13x13x9 Good Formol P Transverse 20 Al. coch. 1914 Shrunken
836 E.,4.0 Ch., 22x18x11 Exc. Corros. acetic P Transverse 15 Al. coch. 1914 Less advanced
963 E.,4.0 Ch., 23x18x16 Good Formol P Coronal 20 Al. coch. 1914
1075 E.,6.0 Ch., 46x32x20 Exc. Corros. acetic P Coronal 20 (Stain - Haematoxylin Eosin) or. G. 1915 Most advanced in group
3956 E., 4.0 Poor Formol P Transverse 20 Al. coch. 1922 Tubal Incomplete
4046 E.,5 Ch., 22x20x20 Poor Formol P Transverse 50 Al. coch. 1922
5541 E., 6.0 Ch., 35x30x20 Good Formol P Transverse 10 Al. coch., eosin 1927
5682 E., 5.3 Ch., 29x25x13 Poor Formol P Coronal 20 Al. coch. 1928
5874 E., 4.8 Exc. Bouin P Transverse 10 (Stain - Haematoxylin Eosin) 1929 Hysterotomy. Bromides only
6032 E., 5.8 Ch., 30x24x13 Poor Formol P P ? p 1929 Not good enough to cut
6469 E., 5.0 Ch., 25x18x18 Poor Formol P P P P 1932 Fragmented on cutting. Not saved
6473 E., 5.0 Ch, 30x30x15 Exc. Formol C-P Coronal 6 Al. coch. 1932 Less advanced. Ag added
7433 E., 5.2 Ch., 15x13x13 Exc. Formol C-P Coronal 8 (Stain - Haematoxylin Eosin) 1937 Tubal
7618 E, 48 Ch, 18x15x15 Exc. Bouin C-P Coronal 10 (Stain - Haematoxylin Eosin) 1939 Hystereaomy. Advanced. Ag added
7669 E, 5.0 Ch., 23x16x14 Good Formol C-P Coronal 6 (Stain - Haematoxylin Eosin) 1939 Hysterectomy. Least advanced in group, Ag added
7889 E, 4.2 Exc. Bouin C-P Coronal 6 (Stain - Haematoxylin Eosin) 1941 Hysterectomy
8066 E,53 C h , 20x18xI8 Exc. Bouin C-P Transverse 8 (Stain - Haematoxylin Eosin) 1942 Hysterectomy. Ag added to slide 2
8119 E., 5.3 Ch., 32x28x6.5 Exc. Bouin C-P Transverse 8 (Stain - Haematoxylin Eosin) 1943 Hysterectomy
8147 E., 5.2 Ch., 27x21x19 Poor Formol ? ? p p 1943 Tubal Not cut
8239 E., 4.3 Exc. Bouin C-P Sagittal 8 H. phlox. 1944
8372 E., 5.6 Exc. Alc.& Bouin P Transverse 10 Azan 1946
8581 E., 4.8 Good Kaiserling C-P Sagittal 8 Azan 1948 Most-advanced third
8967 E., 5.7 Exc. Acetic Zenker C-P Transverse 6 (Stain - Haematoxylin Eosin) 1931 Head injured. Univ. Chicago No. H1426
9296 E,4.5 Exc. C-P Coronal 8 Azan 1955
9297 E., 4.5 Exc. C-P Sagittal 8 Azan 1955
9697 E., 5.5 Bouin 1956 not cut
Abbreviations
  • Size - E. is the greatest length of the embryo and Ch. is the mean diameter of the chorion.
  • Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections.
  • Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P).
  • Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution)
  • Stain -
  •  ? - unknown or not determined.

Embryo Examples

  • His embryo (a), 4 mm. Described in detail by His (1880).[1]
  • Fischel embryo, 4.2 mm, Hochstetter Atlas.[2] This embryo is sharply and spirally curved, and the length given is approximate. Its place in stage 13 is verified by the form of the limb buds.
  • Keibel embryo No. 112, 5.3 mm. Described in the Keibel and Elze Normentafeln (1908).[3] The lens is a flat, slightly thickened disc. The otic vesicle is detached, but a remnant of the stalk is still present; there is some indication of the endolymphatic appendage. There are 36 pairs of somites.
  • R. Meyer, 5-mm embryo, No. 318, Anatomisches Institut, Zurich. This embryo is a more advanced example of stage 13. The epithelium of the lens disc begins to indent. There are 38 pairs of somites. The embryo is referred to in the Keibel and Elze Normentafeln.[3]
  • C. Rabl, 4-mm embryo. The specimen closely resembles the Fol 5.6-mm embryo and the Hertwig G 31 embryo. It was used by Rabl in his study of the face (1902).[4]
  • Broman, embryo Lf., 3 mm, Anatomisches Institut, Lund. This embryo was described systematically by Broman (1896).[5] He made revisions for the Keibel and Elze Normentafeln.[3] Broman reports that it has 30 pairs of somites. Regarding its relatively small size, it is to be noted that it was fixed in absolute alcohol and then preserved for two years in weak spirits. This embryo is a less advanced example of stage 13.
  • Carnegie No. 148, 4.3 mm. A monographic description of this embryo was published by Gage (1905).[6]
  • Fol, 5.6-mm embryo. This well-preserved embryo is a more advanced example. It was carefully described and illustrated by Fol (1884).[7]
  • Hertwig, 4.9-mm embryo, G31 Anatomisches-biologisches Institut, Berlin. This well-preserved embryo, a typical representative of stage 13, was first described in a study of the development of the pancreas by Jankelowitz (1895).[8] An excellent systematic study followed later (Ingalis, 1907,[9] 1908[10] (Cited by Streeter 1945). The embryo was considered also in the Keibel and Elze Normentafeln.[3] There are 35 pairs of somites.
  • 4-mm and 5-mm twin embryos, University of Basel. A graphic reconstruction of the normal specimen was Issued by Müller and O'Rahilly (1980a),[11](1980a)</ref> and reconstructions, with particular reference to the nervous system, were published by Müller and O'Rahilly (1984),[12] who described the cerebral dysraphia (future anencephaly) present in one twin.
  • Free Hospital for Women, Brookline, Massachusetts, No. 5, 5 mm. The histochemistry of this embryo was studied by McKay et al. (1955).[13]

References

  1. His W. Anatomie Menschliche Embryonen I - Embryonen des ersten monats (Anatomy of human embryos - Embryos of the first month). (1880) Leipzig.
  2. Hochstetter, F. 1907. Atlas. Munich. Cited by Streeter (1945).
  3. 3.0 3.1 3.2 3.3 Keibel F. and Elze C. Normal Plates of the Development of the Human Embryo (Homo sapiens). (1908) Vol. 8 in series by Keibel F. Normal plates of the development of vertebrates (Normentafeln zur Entwicklungsgeschichte der Wirbelthiere) Fisher, Jena., Germany.
  4. Rabl,C. 1902. Tafelnzur Entwicklungs geschichte der aussern Kdrperform der Wirbeltiere. Leipzig. Cited by Streeter (1945).
  5. Broman, 1.1896. Beschreibung eines menschlichen Embryos von beinahe 3-mm. Lange. Morphol. Arbeit, 5. Cited by Streeter (1945).
  6. Gage SP. A three weeks' human embryo, with especial reference to the brain and nephric system. (1905) Amer. J Anat. 4: 409-443.
  7. Fol., H. 1884. Description d'un embryon humain de cinq millimetres et six dixiemes. Rec. zool. suisse, 1, 357-401.
  8. Jankelowitz, A. 1895. Ein junger menschlicher Embryo und die Entwicklung des Pancreas bei demselben. Arch mikr.anat. Entw., 46, 702-708. Cited by Streeter (1945).
  9. Ingalls, N.W. 1907. Beschreibung eines menschlichen Embryos von 4:9 mm. Arch, mikr.-anat. Entw., 70, 506-576.
  10. Ingalls NW. A contribution to the embryology of the liver and vascular system in man. (1908 ) Anat. Rec. 2:338–344.
  11. Müller F & O'Rahilly R. (1980). The early development of the nervous system in staged insectivore and primate embryos. J. Comp. Neurol. , 193, 741-51. PMID: 7440789 DOI.
  12. Müller F & O'Rahilly R. (1984). Cerebral dysraphia (future anencephaly) in a human twin embryo at stage 13. Teratology , 30, 167-77. PMID: 6388010 DOI.
  13. McKAY DG, ADAMS EC, HERTIG AT & DANZIGER S. (1955). Histochemical horizons in human embryos. I. Five millimeter embryo, Streeter horizon XIII. Anat. Rec. , 122, 125-51. PMID: 13238850

Pages in category ‘Carnegie Stage 13’

The following 81 pages are in this category, out of 81 total.

Media in category ‘Carnegie Stage 13’

The following 188 files are in this category, out of 188 total.