Carnegie stage 8
Features: embryonic disc, primitive node, primative streak, primative groove, connecting stalk
Facts: Week 3, 17 - 19 days, 1.0 - 1.5 mm
View: embryonic disc, showing the epiblast viewed from the amniotic (dorsal) side. Amniotic membrane removed, connecting stalk to the left.
Events: Gastrulation is continuing as cells migrate from the epiblast, continuing to form mesoderm.
Mesoderm lies between the ectoderm and endoderm as a continuous sheet except at the buccopharyngeal and cloacal membranes. These membranes have ectoderm and endoderm only and will lie at the rostral (head) and caudal (tail) of the gastrointestinal tract.
From the primitive node a tube extends under the ectoderm in the opposite direction to the primitive streak. This tube forms first the axial process then notochordal process, then finally the notochord.
The notochord is a key to embryonic folding and regulation of ectoderm and mesoderm differentiation. It lies in the rostrocordal axis and the embryonic disc will fold either side ventrally, pinching off a portion of the yolk sac to form the lining of the gastrointestinal tract.
Image source: Embryology page Created: 19.03.1999
About Carnegie Stages
Carnegie stages are named after the famous US Institute which began collecting and classifying embryos in the early 1900's. Stages are based on the external and/or internal morphological development of the embryo, and are not directly dependent on either age or size. The human embryonic period proper is divided into 23 Carnegie stages. Carnegie stages are based on the external and/or internal morphological development of the embryo, and are not directly dependent on either age or size. Criteria beyond morphological features include age in days, number of somites present, and embryonic length.
The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota for tutorial/revision purposes and cannot be reproduced electronically or in writing without permission.
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