Carnegie stage 5
Embryology - 19 Apr 2024 Expand to Translate |
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Introduction
Facts: Week 1 - 2, size 0.1 - 0.2 mm
SummaryImplantation completed, inner cell mass, bilaminar embryo, trophoblast development, no villous development. See also Events
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Stage 5 Links: Week 2 | Implantation | Lecture | Practical | Carnegie Embryos | Category:Carnegie Stage 5 | Next Stage 6 | ||
Historic Papers: 1941 | 1944 day 9-10 | 1945 day 7.5 | 1945 day 9-10 | ||
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Week: | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Carnegie stage: | 1 2 3 4 | 5 6 | 7 8 9 | 10 11 12 13 | 14 15 | 16 17 | 18 19 | 20 21 22 23 |
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Embryonic Disc
The "embryonic disc" was historically called the "germ disc", on the basis that it was the earliest stage (germinal) if the entire embryo.
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Carnegie 7699 11 day
Carnegie 7950 12 day
Carnegie 7700 12 day
Carnegie 8558 12 day
Carnegie 8330 12 day
Animation
<html5media height="300" width="250">File:Chorion 001.mp4</html5media> |
Animation (left) shows the events following implantation and focuses on changes in the the spaces surrounding the embryonic disc, the extraembryonic coelom. The blastoceol cavity is converted into two separate spaces: the yolk sac and the chorionic cavity. The third space lies above the epiblast, the amniotic cavity.
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Chorionic Cavity Movie | MP4 movie |
Surface View
This is a uterine surface view showing the site of implantation (pale region in centre of image). The conceptus can be identified located at the dark central region within the pale region.
Carnegie Collection
Stage 5a
Stage 5b
Carnegie 8215
Carnegie 8215 embryo, chorionic cavity and trophoblast
Carnegie 8171 predecidual reaction
Carnegie 8171 embryo and trophoblast
Carnegie 8004 endometrium and intact specimen
Carnegie 8004 embryo, chorionic cavity and trophoblast
Stage 5c
Carnegie 7699 11 day
Carnegie 7950 12 day
Carnegie 7700 12 day
- Hertig1956 fig31-32.jpg
Carnegie 855812-day
Carnegie 8330 12-day
Carnegie Collection - Stage 5 | ||||||||||
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Serial No. | Stage | Grade | Fixative | Embedding Medium | Thinness (µm) | Stain | Year | Notes | ||
8020 | 5a | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1942 | Hertig and Rock (1945a)[1] | ||
8155 | 5a | Exc. | Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1943 | Hertig and Rock (1949)[2] | ||
8225 | 5a | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1944 | Hertig and Rock (1945b)[3] | ||
8004 | 5b | Exc | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1942 | Hertig and Rock (1945a)[1] | ||
8171 | 5b | Exc | Alc. | C-P | 6 | (Stain - Haematoxylin Eosin) | 1943 | Hertig and Rock (1949)[2] | ||
8215 | 5b | Exc | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1944 | Hertig and Rock (1945c)[4] | ||
9350 | 5b | Exc | Bouin | ? | ? | (Stain - Haematoxylin Eosin) | 1955 | Heuser (1956)[5] | ||
4900 | 5c | Poor | p | P | 10 | p | 1925 | Incomplete. Streeter (1926)[6] | ||
7699 | 5c | Exc. | Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1939 | Hertig and Rock (1941)[7] | ||
7700 | 5c | Exc. | Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1938 | Hertig and Rock (1941)[7] | ||
7771 | 5c | Exc. | Bouin | C-P | 10 | (Stain - Haematoxylin Eosin) | 1940 | Abnormal | ||
7950 | 5c | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1941 | Hertig and Rock (1944)[8] | ||
8000 | 5c | Poor | Alc. & Bouin | C-P | 8 | (Stain - Haematoxylin Eosin) | 1942 | Abnormal | ||
8139 | 5c | Exc. | ? | C-P | 6 | (Stain - Haematoxylin Eosin) | 1943 | Incomplete. Marchetti (1945)[9] | ||
8299 | 5c | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin), phlox. | 1945 | Abnormal | ||
8329 | 5c | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin), phlox. | 1945 | Abnormal | ||
8330 | 5c | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin), phlox. | 1945 | |||
8370 | 5c | Poor | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin), phlox. | 1946 | Abnormal | ||
8558 | 5c | Exc. | Alc. & Bouin | C-P | 6 | (Stain - Haematoxylin Eosin) | 1947 | |||
Stage 5 was originally subdivided into 3 sequential parts a, b, c.
Abbreviations
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References
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iBook - Carnegie Embryos | |
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Historic Stage 5 Embryos
Historic stage 5 embryo data modified from O'Rahilly and Müller (1987).[1]
Stage 5a
- Carnegie No. 8225 - Described briefly by Hertig and Rock (1945b). Hysterectomy (bicornuate uterus). Anterior wall of uterus. Chorion, 0.33 x 0.306 mm. Chorionic cavity, 0.228 x 0.2 mm. Embryonic disc, 0.09 x 0.078 mm. Perhaps more advanced than Carnegie No. 8020 (Mazanec, 1959; Harris and Ramsey, 1966)[2], but has also been interpreted as less advanced.[3] Photomicrograph in Hertig, Rock, and Adams (1956, fig. 9 and 10). Presumed age, 7 days.
- Carnegie No. 8020 - (figs. 5-3 to 5-5). Described by Hertig and Rock (1945a).[4] Hysterectomy. Posterior wall of uterus. Chorion, 0.45 x 0.3 mm. Chorionic cavity, 0.288 x 0.186 mm. Embryonic disc, 0.126 x 0.092 mm. New model of blood vessels at implantation site has been prepared (Harris and Ramsey, 1966)[2]. Presumed age, 7 days.
- Fruhling, Ginglinger, and Gandar (1954) described briefly a specimen of about 8 days. Curettage. Early implantation. Few trophoblastic digitations. Beginning amniotic cavity. Most sections through embryonic disc lost.
- Carnegie No. 8155 - (fig. 14). Described by Hertig and Rock (1949).[5] Hysterectomy. Anterior wall of uterus. Chorion, 0.306 x 0.210 mm. Chorionic cavity, 0.168 x 0.082 mm. Embryonic disc, 0.09 x 0.05 mm. “Tropho-epiblastic cavity” (Luckett, 1975).
Stage 5b
- Carnegie No. 8171 - Described by Hertig and Rock (1949). Hysterectomy. Posterior wall of uterus. Abnormal leucocytic infiltration of endometrium. Chorion, 0.422 x 0.404 mm. Chorionic cavity, 0.164 X 0.138 mm. Embryonic disc, 0.114 x 0.088 mm. A cellular remnant within the umbilical vesicle, because it is probably derived from the endoderm, “may, in a sense, be regarded as an abnormal form of twin embryo” (ibid.). Presumed age, 9 days.
- Carnegie No. 8215 - Described briefly by Hertig and Rock (1945c). Hysterectomy. Posterior wall of uterus. Chorion, 0.525 X 0.498 mm. Chorionic cavity, 0.228 X 0.21 mm. Embryonic disc, 0.084 x 0.052 mm. Lacunae perhaps further developed than in No. 8171 (Mazanec, 1959), but specimen has been “considered to be slightly younger because the decidual reaction is not yet apparent” (Hertig, Rock, and Adams, 1956). Photomicrographs in Hertig, Rock, and Adams (1956, figs. 15 and 17). Presumed age, 9 days.
- Carnegie No. 8004 - (figs. 5-7 to 5-9). Described by Hertig and Rock (1945a). Hysterectomy. Posterior wall of uterus. Chorion, 0.582 x 0.45 mm. Chorionic cavity, 0.312 X 0.185 mm. Embryonic disc, 0.132 x 0.1 mm.
- Carnegie No. 9350 - Described briefly by Heuser (1956). Hysterectomy. At junction of posterior and anterior walls. Chorion, 0.59 x 0.58 mm. Chorionic cavity, 0.3 X 0.1 mm. Embryonic disc, 0.132 x 0.09 mm. Presumed age, 9 days.
Stage 5c
- Macafee - Described by Morton (1949)[6]. Curettage. Probably belongs to stage 5. Embryonic disc not found.
- Davies-Harding - Described by Davies (1944). Hysterectomy. Anterior wall of uterus. Incomplete (almost one-half of embryonic disc missing). “No true villi.” Primary umbilical vesicle present. Extensive extra-embryonic meshwork. Slightly later stage of development than No. 8004 (Davies, 1944, Addendum), which belongs to 5b. “Possibly pathological” (Boyd and Hamilton, 1970). Chorion, 1.18 x 0.55 mm. Chorionic cavity, 0.409 x 0.238 mm. Embryonic disc, 0.117 mm. May be regarded as transitional between 5b and 5c. Presumed age, 9-10 days.
- Carnegie No. 7699 - Described by Hertig and Rock (1941). Hysterectomy. Posterior wall of uterus. Chorion, 1.026 x 0.713 mm. Chorionic cavity, 0.48 x 0.336 mm. Embryonic disc, 0.138 x 0.138 mm. New model of blood vessels at implantation site has been prepared (Harris and Ramsey, 1966). Presumed age, 11 days.
- Carnegie No. 4900 - Miller. Described by Streeter (1926). Curettage. Angiogenesis described by Hertig (1935). Incomplete (some sections missing). Primary umbilical vesicle present. New graphic reconstruction made by Streeter (1939a,b). Chorion, 0.9 mm. Chorionic cavity, 0.4 mm. Presumed age, 10-11 days or perhaps even 12 days (Krafka,1941).
- Dible-West. Described by Dible and West (1941)Cite error: Closing
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tag - Sch. (Schönig). A pathological specimen of stage 5 described by von Möllendorff (1921a).
- Keller and Keller (1954) found a pathological specimen embedded in the stroma of the ostium uteri.
Several pathological specimens of stage 5c are in the Carnegie Collection. Nos. 8370, 7770, 8299 (malpositioned embryonic disc, Hertig, 1968, fig. 132), 8329, 8000 (superficial implantation), and 7771 (no embryo) were measured and illustrated by Hertig, Rock, and Adams (1956).[3]
Events
- Mitosis - cells on surface of blastocyst (trophoblast cells) divide more rapidly than the inner cells (inner cell mass, embryoblast)
- Implantation - adhesion to endometrium epithelium and implantation through this layer into the underlying uterine storm.
- Endocrine signalling - trophoblast cells secrete hCG (human Chorionic Gonadotropin/Gonadotrophin) the signal of pregnancy.
- Cell invasion and fusion - trophoblast cells spread through the maternal uterine wall and also fuse together to form specialised multi-nucleated cells.
- Corpus luteum - signal from trophoblasts maintain this endocrine tissue in the maternal ovary that secretes progesterone.
References
- ↑ O'Rahilly R. and Müller F. Developmental Stages in Human Embryos. Contrib. Embryol., Carnegie Inst. Wash. 637 (1987).
- ↑ 2.0 2.1 Harris JWS. and Ramsey EM. The morphology of human uteroplacental vasculature. (1966) Contrib. Embryol., Carnegie Inst. Wash. Publ. 625, 38: 43-58.
- ↑ 3.0 3.1 Hertig AT. Rock J. and Adams EC. A description of 34 human ova within the first 17 days of development. (1956) Amer. J Anat., 98:435-493.
- ↑ Hertig AT. and Rock J. Two human ova of the pre-villous stage, having a developmental age of about seven and nine days respectively. (1945) Contrib. Embryol., Carnegie Inst. Wash. Publ. 557, 31: 65-84.
- ↑ Hertig AT. and Rock J. Two human ova of the pre-villous stage, having a developmental age of about eight and nine days respectively. (1949) Contrib. Embryol., Carnegie Inst. Wash. Publ. 583, 33: 169-186.
- ↑ 6.0 6.1 Morton WRM. Two early human embryos. (1949) J. Anat., 83: 308-314.
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Cite this page: Hill, M.A. (2024, April 19) Embryology Carnegie stage 5. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_5
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G