Difference between revisions of "Carnegie stage 5"

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{{Carnegie Embryo iBook table}}

Revision as of 23:50, 20 July 2015

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Introduction

Human embryo Carnegie stage 5 Facts: Week 1 - 2, size 0.1 - 0.2 mm

Features: implantation completed, inner cell mass, bilaminar embryo, trophoblast development.

  • The conceptus completes implantation during this stage.
  • The trophoblast cells (syncytiotrophoblast and cytotrophoblast) proliferate. Syncytiotrophoblast cells continue to invade the maternal endometrium and cytotrophoblast cells form clumps that will later form sites of chorionic villi formation.
  • The maternal endometrium locally begins the decidual process and the endometrial stroma accumulates fluid (edematous).
  • The extraembryonic cavities begin to form.
  • The bilaminar embroyonic disc forms from the inner cell mass (embryoblast).

Stage5 bf22L.jpg


Links: Week 2 | Implantation | Lecture | Practical | Stage 6
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Animation (left) shows the events following implantation and focuses on changes in the the spaces surrounding the embryonic disc, the extraembryonic coelom.

The blastoceol cavity is converted into two separate spaces: the yolk sac and the chorionic cavity.

The third space lies above the epiblast, the amniotic cavity.

blue - epiblast layer
yellow - hypoblast layer
red cells - extraembryonic mesoderm layer
green - trophoblast layer
red spaces - blood-filled spaces, maternal lacunae
white cells - (left) endometrial gland (right) endometrial epithelium
Chorion 001 icon.jpg
Chorionic Cavity Movie | MP4 movie

Surface View

This is a uterine surface view showing the site of implantation (pale region in centre of image). The conceptus can be identified located at the dark central region within the pale region.

Stage5 bf04.jpg

Carnegie Collection

Stage 5a

Stage 5b

Stage 5c


Carnegie Collection - Stage 5 
Serial No. Stage Grade Fixative Embedding Medium Thinness (µm) Stain Year Notes
8020 5a Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin) 1942 Hertig and Rock (1945a)[1]
8155 5a Exc. Bouin C-P 6 (Stain - Haematoxylin Eosin) 1943 Hertig and Rock (1949)[2]
8225 5a Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin) 1944 Hertig and Rock (1945b)[3]
8004 5b Exc Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin) 1942 Hertig and Rock (1945a)[1]
8171 5b Exc Alc. C-P 6 (Stain - Haematoxylin Eosin) 1943 Hertig and Rock (1949)[2]
8215 5b Exc Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin) 1944 Hertig and Rock (1945c)[4]
9350 5b Exc Bouin ? ? (Stain - Haematoxylin Eosin) 1955 Heuser (1956)[5]
4900 5c Poor p P 10 p 1925 Incomplete. Streeter (1926)[6]
7699 5c Exc. Bouin C-P 6 (Stain - Haematoxylin Eosin) 1939 Hertig and Rock (1941)[7]
7700 5c Exc. Bouin C-P 6 (Stain - Haematoxylin Eosin) 1938 Hertig and Rock (1941)[7]
7771 5c Exc. Bouin C-P 10 (Stain - Haematoxylin Eosin) 1940 Abnormal
7950 5c Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin) 1941 Hertig and Rock (1944)[8]
8000 5c Poor Alc. & Bouin C-P 8 (Stain - Haematoxylin Eosin) 1942 Abnormal
8139 5c Exc. ? C-P 6 (Stain - Haematoxylin Eosin) 1943 Incomplete. Marchetti (1945)[9]
8299 5c Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin), phlox. 1945 Abnormal
8329 5c Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin), phlox. 1945 Abnormal
8330 5c Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin), phlox. 1945
8370 5c Poor Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin), phlox. 1946 Abnormal
8558 5c Exc. Alc. & Bouin C-P 6 (Stain - Haematoxylin Eosin) 1947
Stage 5 was originally subdivided into 3 sequential parts a, b, c.

Abbreviations

  • Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections.
  • Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P).
  • Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution)
  •  ? - unknown or not determined.
References
  1. 1.0 1.1 Hertig AT. and Rock J. Two human ova of the pre-villous stage, having a developmental age of about seven and nine days respectively. (1945) Contrib. Embryol., Carnegie Inst. Wash. Publ. 557, 31: 65-84.
  2. 2.0 2.1 Hertig, A. T., and Rock, J. 1949. Two human ova of the pre-villous stage, having a developmental age of about eight and nine days respectively. Carnegie Instn. Wash. Publ. 583, Contrib. Embryol., 33, 169-186
  3. Hertig AT. and Rock J. On a normal human ovum not over 7.5 days of age. (1945) Anat. Rec, 91: 281.
  4. Hertig, A. T., and Rock J. 1945c. On a normal ovum of approximately 9 to 10 days of age. Anat. Rec, 91,281.
  5. Heuser, C. H. 1956. A human ovum with an estimated ovulation age of about nine days. Anat. Rec, 124, 459.
  6. Streeter, G. L. 1926. The "Miller" ovum—the youngest normal human embryo thus far known. Carnegie Instn. Wash. Publ 363, Contrib. Embryol., 18, 31-48.
  7. 7.0 7.1 Hertig, A. T., and Rock, J. 1941. Two human ova of the pre-villous stage, having an ovulation age of about eleven and twelve days respectively. Carnegie Instn. Wash. Publ. 525, Contrib. Embryol., 29, 127-156.
  8. Hertig, A. T., and Rock, J. 1944. On the development of the early human ovum, with special reference to the trophoblast of the previllous stage: a description of a normal and 5 pathologic human ova. Amer. J. Obstet Gynecol, 47, 149-184.
  9. Marchetti AA. A pre-villous human ovum accidentally recovered from a curettage specimen. (1945) Contrib. Embryol., Carnegie Inst. Wash. Publ. 557, 31: 107-115.


iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).


Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2020, April 6) Embryology Carnegie stage 5. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_5

What Links Here?
© Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G