Carnegie stage 15

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Introduction

Stage15 bf1c.jpg

Facts

Facts: Week 5, 35 - 38 days, 7 - 9 mm

Gestational Age GA week 7

Summary

  • Ectoderm: sensory placodes, lens pit, otocyst, nasal pit, primary/secondary vesicles, fourth ventricle of brain,
  • Mesoderm: heart prominence
  • Head: 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum
  • Body: heart, liver, umbilical cord, mesonephric ridge
  • Limb: upper and lower limb buds, hand plate


See also Carnegie stage 15 Events

Features

  • Identify: midbrain region, nasal pit, lens pit, 1st, 2nd and 3rd pharyngeal arches, 1st pharyngeal groove, maxillary and mandibular components of 1st pharyngeal arch, fourth ventricle of brain, heart prominence, cervical sinus, upper limb bud, mesonephric ridge, lower limb bud, umbilical cord Labelled Stage 15
Links: Week 5 | Head | Lecture - Limb | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Category:Carnegie Stage 15 | Stage 16


Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Kyoto Collection

Stage15 bf1.jpg

Embryo Lateral view. Amniotic membrane removed.

Stage15 sagittal section upper half 01.jpg

Embryo Sagittal section - upper half


Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Stage15 bf3.jpg Stage15 bf4.jpg Stage15 bf5.jpg Stage15 bf6.jpg

Stage15 bf7.jpg Stage15 bf8.jpg Stage15 bf9.jpg Stage15 bf10.jpg

Carnegie stage 15: Right | Anterior | Posterior | Left | Right | Anterior | Posterior | Left


Stage 15 Links: Week 5 | Head | Lecture - Limb | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 15 | Next Stage 16
  Historic Papers: 1891 | 1905 Cranial and Spinal Nerves | 1914 | 1926 Precervical Sinus | 1948 stages 15-18


Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23


iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Blechschmidt Collection

7.5mm Embryo movie 1 icon.jpg
 ‎‎Embryo 7.5mm
Page | Play



Image source: The Blechschmidt Collection images are reproduced with the permission of Prof. Christoph Viebahn, director of the Institute of Anatomy and Embryology, , University Medical Center Göttingen. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Madrid Collection

Madrid Collection Embryos  
Carnegie
Stage
Embryo Days CRL (mm) Section
thickness
Staining Section plane
15 GV4 36 7 8 (Stain - Haematoxylin Eosin) transverse

Photograph

Stage15 bf2.jpg Stage15 bf21.jpg

Image: Dr Ed Uthman (Houston, Texas) - other pathology images

Image version links: Virtual Slide | ExtraLarge 1874 x 2000px | Large 959 x 1024px | Medium 468 x 500px

Embryo Virtual Slide

Stage 15 - Ventral View

Stage15 bf2.jpg

 ‎‎Mobile | Desktop | Original

Stage 15 | Embryo Slides

Events

  • Hearing - otic capsule formed by condensed mesenchyme. Ganglion vestibular nerve fibres extend to the otocyst epithelium. External ear auricular hillocks appear, pharyngeal arch 2 forms primordium of the antitragus.
  • Vision - (about 33 days) the lens pit is closed. The lens vesicle and optic cup lie close to the surface ectoderm and appear to press against the surface.[1]
  • Smell - the nasal discs form large oval depressions (nasal pits).
  • Limb - upper limb bud visible as a distal hand plate and a proximal forearm, arm, and shoulder region.
  • Somitogenesis - last stage that somites can be seen from the surface.
  • Cardiovascular
    • Heart - atrioventricular bundle appears, atrioventricular cushions present, conotruncal ridges present, foramen secundum appears and semilunar cusps appear.[2]
    • Coronary circulation plexus of blind epicardial capillaries appears on the heart begin to acquire coronary sinus connection.[3]
    • Cerebral artery vertebral arteries forms from transverse anastomoses between cervical intersegmental arteries, beginning with the proatlantal artery and proceeding downward to the 6th intersegmental artery.[4]
  • Endocrine[5]
    • Epiphysis - pineal body is detectable in the roof of the diencephalon (Stadium I of Turkewitsch 1933) (O'Rahilly 1968).
    • Thyroid - thyroid primordium may be detached from the pharyngeal epithelium in some instances. "At about the time" when the thyroglossal duct "becomes broken it loses its lumen" (Grosser 1912).
    • Adrenal Cortex - primordium is first recognizable. A new type of cell (C1) from the coelomic epithelium is found in the subjacent mesenchyme. New cells (C2) appear in the medial wall of mesonephric glomeruli and begin to migrate into the suprarenal primordium.[6] Jirfisek (1980) denies a mesonephric contribution to the suprarenal.
    • Adrenal Medulla - all types of cells (M1, M2, and M3) increase in number. From stage 15 to stage 18, the suprarenal primordium is cigar-shaped and extends from segment T6 to segment L1, lateral to the aorta and mesogastrium.[6]

References

Additional Images

Mall, F. P. 1891. A human embryo twenty-six days old. J. Morph, 5, 459-480.

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline



Cite this page: Hill, M.A. (2024, March 29) Embryology Carnegie stage 15. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_15

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G