Carnegie stage 13

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Introduction

Stage13 sem1.jpg

Facts

week 4 to week 5, 28 - 32 days.

The embryos have a crown rump length (CRL) of 4 - 6 mm and somite number 30 pairs.

Gestational Age GA - end week 6 beginning week 7

Summary

  • Ectoderm: Neural tube continues to close, Caudal neuropore closes, forebrain
  • Mesoderm: continued segmentation of paraxial mesoderm (21 - 29 somite pairs), heart prominence
  • Head: 1st, 2nd and 3rd pharyngeal arch, forebrain, site of lens placode, site of otic placode, stomodeum
  • Body: heart, liver, umbilical, early upper limb bulge

See also Events

Features

  • 30 somites, forebrain, site of lens placode, site of otic placode , stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somites
  • Identify: forebrain, site of lens placode, site of otic placode, stomodeum, 1st pharyngeal arch, 2nd pharyngeal arch, 3rd pharyngeal arch, heart prominence, somite
Stage 13 - Left Ventrolateral View

Stage13 bf4.jpg

 ‎‎Mobile | Desktop | Original

Stage 13 | Embryo Slides
Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Category:Carnegie Stage 13 | Stage 14

Carnegie Stage 13 Movies: Gastrointestinal Tract | Cardiovascular | Central Nervous System | Carnegie Stage 13 | Stage 22 Movies | Movies

The original animations were part of the UNSW Independent Learning Project (ILP) prepared by Aashish Kumar (2006).
Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Bright Field

Embryo and placenta

Stage13 bf5.gif

Stage13 bf5.jpg Stage13 bf6.jpg

Stage13 bf7.jpg Stage13 bf8.jpg

Stage13 bf9.jpg Stage13 bf10.jpg

Stage13 bf11.jpg Stage13 bf12.jpg

Stage13 bf1.jpg Stage13 bf3.jpg

Embryo Links: Embryo and Placenta | Embryo | Embryo (label) | Embryo (animated) | Embryo (animated large) | Head region | Head region (label) | Body region | Body region (label) | Carnegie stage 13
Stage 13 Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Movies | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 13 | Next Stage 14
  Historic Papers: 1905 Embryo 148 | 1926 Precervical Sinus | 1945 | 1955

Embryo Virtual Slide

Stage 13 - Left Ventrolateral View

Stage13 bf4.jpg

 ‎‎Mobile | Desktop | Original

Stage 13 | Embryo Slides

Scanning EM

Stage13 sem1c.jpg

Stage13 sem2c.jpg

Stage13 sem3c.jpg

Kyoto Collection

Stage13 bf2.jpg

Human Stage13 sagittal upper half01.jpg Human Stage13 sagittal upper half02.jpg
Upper half of embryo shown in median sagittal plane. Scale bar 1 mm.
Stage13 face ventral view01.jpg Stage13 oral cavity floor01.jpg
Upper half of embryo shown in ventral view. Scale bar 0.5 mm. Oral cavity floor. Scale bar 0.5 mm.
Stage 13 EFIC01.jpg
Stage 13 EFIC01.jpg
 ‎‎Sagittal EFIC
Page | Play
Stage 13 MRI S01.jpg
 ‎‎Heart Sag MRI
Page | Play
Stage13 oral cavity floor02.jpg


Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Stage13 bf13.jpg Stage13 bf14.jpg Stage13 bf15.jpg Stage13 bf16.jpg Stage13 bf17.jpg Stage13 bf18.jpg Stage13 bf19.jpg Stage13 bf20.jpg Stage13 bf21.jpg

Carnegie stage 13: 6473 left | 6473 dorsal | 6473 right | 6469 right | 8066 dorsal | 8066 left | 8119 left | 7433 right | 7433 ventral
Carnegie Collection Embryos - Stage 13 
Serial No. Size (mm) Grade Fixative Embedding Medium Plane Thinness (µm) Stain Year Notes
1 E.,4.5 Ch., 30x30 Poor Salicylic acid P Transverse 10 Hemat. 1887 Obtained by Mall while student
19 E., 5.5 Ch., 18x14 Poor p ? Transverse 20 Al. coch. 1895
98 E., 4 Ch., 24x16x9 Poor p P Transverse 20 Al. coch. 1896
76 E., 4.5 Ch., 22x20 Poor Alc. P Transverse 20 Al. coch. 1897
112 E., 4 Poor p P Sagittal 10 Al. coch. p
116 E., 5 Poor p ? Sagittal 10 Al. coch. 1898
148 E.,4.3 Ch., 17x14x10 Poor Alc. P Coronal 10 (Stain - Haematoxylin Eosin) 1899 Abnormal. Nasal discs fused
186 E.,3.5 Ch., 25x20x15 Poor Alc. P Transverse 20 Al. coch. 1901
239 E., 3.0 Poor Formalin P Transverse 10 (Stain - Haematoxylin Eosin) 1903
248 E., 4.5 Ch., 30x23x15 Poor p ? Coronal 50 Al. coch. 1904
407 E.,4 Ch., 14x13X7 Poor Formalin ? Transverse 40 Al. coch. 1907
463 E., 3.9 Ch., 17x12x7 Good Formalin P Coronal 10 Al. coch. 1910
523 E., 5 Ch., 25x25x15 Fair Formalin P Transverse p Al. coch. 1911
588 E., 4.0 Ch., 19x15x8 Good Corros. acetic P Coronal 15 (Stain - Haematoxylin Eosin) 1912 Advanced
786 E., 4.5 Ch., 19x10x10 Poor Alc. P Sagittal 15 Al. coch. 1913
800 E., 6.0 Good Corros. acetic P Transverse 10 H 1913 Curettage. Anencephaly
808 E.,4.0 Poor Corros. acetic P Transverse 15 Al. coch. 1914 Tubal Incomplete
826 E., 5.0 Ch., 13x13x9 Good Formalin P Transverse 20 Al. coch. 1914 Shrunken
836 E.,4.0 Ch., 22x18x11 Exc. Corros. acetic P Transverse 15 Al. coch. 1914 Less advanced
963 E.,4.0 Ch., 23x18x16 Good Formalin P Coronal 20 Al. coch. 1914
1075 E.,6.0 Ch., 46x32x20 Exc. Corros. acetic P Coronal 20 (Stain - Haematoxylin Eosin) or. G. 1915 Most advanced in group
3956 E., 4.0 Poor Formalin P Transverse 20 Al. coch. 1922 Tubal Incomplete
4046 E.,5 Ch., 22x20x20 Poor Formalin P Transverse 50 Al. coch. 1922
5541 E., 6.0 Ch., 35x30x20 Good Formalin P Transverse 10 Al. coch., eosin 1927
5682 E., 5.3 Ch., 29x25x13 Poor Formalin P Coronal 20 Al. coch. 1928
5874 E., 4.8 Exc. Bouin P Transverse 10 (Stain - Haematoxylin Eosin) 1929 Hysterotomy. Bromides only
6032 E., 5.8 Ch., 30x24x13 Poor Formalin P P ? p 1929 Not good enough to cut
6469 E., 5.0 Ch., 25x18x18 Poor Formalin P P P P 1932 Fragmented on cutting. Not saved
6473 E., 5.0 Ch, 30x30x15 Exc. Formalin C-P Coronal 6 Al. coch. 1932 Less advanced. Ag added
7433 E., 5.2 Ch., 15x13x13 Exc. Formalin C-P Coronal 8 (Stain - Haematoxylin Eosin) 1937 Tubal
7618 E, 48 Ch, 18x15x15 Exc. Bouin C-P Coronal 10 (Stain - Haematoxylin Eosin) 1939 Hystereaomy. Advanced. Ag added
7669 E, 5.0 Ch., 23x16x14 Good Formalin C-P Coronal 6 (Stain - Haematoxylin Eosin) 1939 Hysterectomy. Least advanced in group, Ag added
7889 E, 4.2 Exc. Bouin C-P Coronal 6 (Stain - Haematoxylin Eosin) 1941 Hysterectomy
8066 E,53 Ch , 20x18xI8 Exc. Bouin C-P Transverse 8 (Stain - Haematoxylin Eosin) 1942 Hysterectomy. Ag added to slide 2
8119 E., 5.3 Ch., 32x28x6.5 Exc. Bouin C-P Transverse 8 (Stain - Haematoxylin Eosin) 1943 Hysterectomy
8147 E., 5.2 Ch., 27x21x19 Poor Formalin ? ? p p 1943 Tubal Not cut
8239 E., 4.3 Exc. Bouin C-P Sagittal 8 H. phlox. 1944
8372 E., 5.6 Exc. Alc.& Bouin P Transverse 10 Azan 1946
8581 E., 4.8 Good Kaiserling C-P Sagittal 8 Azan 1948 Most-advanced third
8967 E., 5.7 Exc. Acetic Zenker C-P Transverse 6 (Stain - Haematoxylin Eosin) 1931 Head injured. Univ. Chicago No. H1426
9296 E,4.5 Exc. C-P Coronal 8 Azan 1955
9297 E., 4.5 Exc. C-P Sagittal 8 Azan 1955
9697 E., 5.5 Bouin 1956 not cut
Abbreviations
  • Size - E. is the greatest length of the embryo and Ch. is the mean diameter of the chorion.
  • Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections.
  • Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P).
  • Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution)
  • Stain -
  • ? - unknown or not determined.


iBook - Carnegie Embryos  
link=http://itunes.apple.com/au/book/the-carnegie-staged-embryos/id510004473?mt=11 iTunes link
  • iTunes link | iBook Store
  • Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology.
  • Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English.
  • PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning).
  • The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Hill Collection

Hill HH145
HillH145 Stage 13 bf01.jpg HillH145 Stage 13 bf02.jpg
HillH145 Stage 13 bf03.jpg HillH145 Stage 13 bf04.jpg
HillH145 Stage 13 bf05.jpg HillH145 Stage 13 bf06.jpg
HillH145 Stage 13 bf07.jpg HillH145 Stage 13 bf08.jpg
Links: Hill Collection

Stage 13 Serial Section Images

These are the original serial images prepared from embryo sections for Embryology practical classes and transferred online in 1996. This embryo shows some features present on the later Stage 14 embryo.

Links: Carnegie stage 13 - serial sections | Carnegie stage 22 - serial sections | Carnegie stage 22

Labeled Sections

Stage 13 serial labeled images
Stage 13 image 050.jpg Stage 13 image 051.jpg Stage 13 image 052.jpg Stage 13 image 053.jpg Stage 13 image 054.jpg Stage 13 image 055.jpg Stage 13 image 056.jpg
A1L A2L A3L A4L A5L A6L A7L
Stage 13 image 057.jpg Stage 13 image 058.jpg Stage 13 image 059.jpg Stage 13 image 060.jpg Stage 13 image 061.jpg Stage 13 image 062.jpg Stage 13 image 063.jpg
B1L B2L B3L B4L B5L B6L B7L
Stage 13 image 064.jpg Stage 13 image 065.jpg Stage 13 image 066.jpg Stage 13 image 067.jpg Stage 13 image 068.jpg Stage 13 image 069.jpg Stage 13 image 070.jpg
C1L C2L C3L C4L C5L C6L C7L
Stage 13 image 071.jpg Stage 13 image 072.jpg Stage 13 image 073.jpg Stage 13 image 074.jpg Stage 13 image 075.jpg Stage 13 image 076.jpg Stage 13 image 077.jpg
D1L D2L D3L D4L D5L D6L D7L
Stage 13 image 078.jpg Stage 13 image 079.jpg Stage 13 image 080.jpg Stage 13 image 081.jpg Stage 13 image 082.jpg Stage 13 image 083.jpg Stage 13 image 084.jpg
E1L E2L E3L E4L E5L E6L E7L
Stage 13 image 085.jpg Stage 13 image 086.jpg Stage 13 image 087.jpg Stage 13 image 088.jpg Stage 13 image 089.jpg Stage 13 image 090.jpg Stage 13 image 091.jpg
F1L F2L F3L F4L F5L F6L F7L
Stage 13 image 092.jpg Stage 13 image 093.jpg Stage 13 image 094.jpg Stage 13 image 095.jpg Stage 13 image 096.jpg Stage 13 image 097.jpg Stage 13 image 098.jpg
G1L G2L G3L G4L G5L G6L G7L


Unlabeled Sections

Stage 13 serial unlabeled images
Stage 13 image 001.jpg Stage 13 image 002.jpg Stage 13 image 003.jpg Stage 13 image 004.jpg Stage 13 image 005.jpg Stage 13 image 006.jpg Stage 13 image 007.jpg
A1 A2 A3 A4 A5 A6 A7
Stage 13 image 008.jpg Stage 13 image 009.jpg Stage 13 image 010.jpg Stage 13 image 011.jpg Stage 13 image 012.jpg Stage 13 image 013.jpg Stage 13 image 014.jpg
B1 B2 B3 B4 B5 B6 B7
Stage 13 image 015.jpg Stage 13 image 016.jpg Stage 13 image 017.jpg Stage 13 image 018.jpg Stage 13 image 019.jpg Stage 13 image 020.jpg Stage 13 image 021.jpg
C1 C2 C3 C4 C5 C6 C7
Stage 13 image 022.jpg Stage 13 image 023.jpg Stage 13 image 024.jpg Stage 13 image 025.jpg Stage 13 image 026.jpg Stage 13 image 027.jpg Stage 13 image 028.jpg
D1 D2 D3 D4 D5 D6 D7
Stage 13 image 029.jpg Stage 13 image 030.jpg Stage 13 image 031.jpg Stage 13 image 032.jpg Stage 13 image 033.jpg Stage 13 image 034.jpg Stage 13 image 035.jpg
E1 E2 E3 E4 E5 E6 E7
Stage 13 image 036.jpg Stage 13 image 037.jpg Stage 13 image 038.jpg Stage 13 image 039.jpg Stage 13 image 040.jpg Stage 13 image 041.jpg Stage 13 image 042.jpg
F1 F2 F3 F4 F5 F6 F7
Stage 13 image 043.jpg Stage 13 image 044.jpg Stage 13 image 045.jpg Stage 13 image 046.jpg Stage 13 image 047.jpg Stage 13 image 048.jpg Stage 13 image 049.jpg
G1 G2 G3 G4 G5 G6 G7


Stage 13 Movies

Stage 13 EFIC01.jpg
 ‎‎Sagittal EFIC
Page | Play
Stage13-ALL-icon.jpg
 ‎‎Systems
Page | Play
Stage13-GIT-icon.jpg
 ‎‎GIT Stage 13
Page | Play
Stage13-CVS-icon.jpg
 ‎‎Cardiovascular
Page | Play
Stage13-CNS-icon.jpg
 ‎‎Stage 13 Neural
Page | Play

Events

  • hearing - otic vesicle closes from surface and endolymphatic appendage apparent. A capillary network forms around the otic vesicle with esoderm becomes condensed as the otic capsule.[1] Vestibulocochlear ganglion (vestibular part) and vestibular nerve fires present.
  • Vision - By the end of the fourth week the optic vesicle lies close to the surface ectoderm. Optic evagination differentiation allows identification of optic part of retina, future pigmented layer of retina, and optic stalk. The surface ectoderm overlying the optic vesicle, in response to this contact, has thickened to form the lense placode.[2]


References

Additional Images

Historic

Historic Disclaimer - information about historic embryology pages 
Mark Hill.jpg
Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding.     (More? Embryology History | Historic Embryology Papers)


Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Embryonic Development



Cite this page: Hill, M.A. (2024, March 28) Embryology Carnegie stage 13. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_13

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G