Carnegie stage 11
Embryology - 19 Apr 2024 Expand to Translate |
---|
Google Translate - select your language from the list shown below (this will open a new external page) |
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Introduction
FactsWeek 4, 23 - 26 days, 2.5 - 4.5 mm, Somite Number 13 - 20 Gestational Age GA - week 6 Summary
This early week 4 embryonic stage shows key features of heart tube and neural plate to tube development. The embryo is still transparent enough to view the underlying somite and transverse septum development.
The embryo is still quite small and is comparable in size to the external yolk sac. There are a number of different images and resources available for this embryonic stage including: | ||
Lateral (right) view of embryo |
Features
rostral neuropore closing, forebrain, neural tube in region of developing spinal cord, somites, caudal neuropore, connecting stalk, amnion
Identify: heart, rostral (cranial, anterior) neuropore closing, forebrain, neural tube in region of developing spinal cord, somites, caudal neuropore, connecting stalk, amnion
- Links: Week 4 | Somitogenesis | Placodes | Lecture - Mesoderm | Lecture - Ectoderm | Lecture - Early Vascular | Science Practical | Category:Carnegie Stage 11 | Stage 12
Week: | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Carnegie stage: | 1 2 3 4 | 5 6 | 7 8 9 | 10 11 12 13 | 14 15 | 16 17 | 18 19 | 20 21 22 23 |
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Bright Field
Embryo dorsal view | Embryo ventral with 1 mm scale bar | Embryo lateral view |
Select image below to open full-size.
- Stage 11 Images: BF1 - dorsal view | BF2 - lateral view | BF3 - ventral with scale bar | BF4 - ventral view | BF5 - lateral view | BF6 - ventral view | BF7 - Kyoto embryo | BF8 - ventral head | BF9 - ventral head | BF10 - dorsal neural | BF11 - ventral embryo and yolk sac | Scanning EM embryo | Carnegie stage 11
Scanning EM
Cranial End of Embryo | |
---|---|
Buccopharyngeal Membrane
The degenerating buccopharyngeal membrane is shown at the floor of the stomodeum.
Neuropores
Neural Crest
Scanning EM showing low power image of whole embryo and region shown in detail box right of neural crest cells.
|
Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.
Kyoto Collection
View: This is a left dorsolateral view of embryo. Amniotic membrane removed.
View: Transverse section (scale bar 0.5 mm)
Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.
Carnegie Collection
iBook - Carnegie Embryos | |
---|---|
|
Carnegie Collection - Stage 11 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Serial No. | Pairs of somites | Size (mm) | Grade | Fixative | Embedding Medium | Plane | Thinness (µm) | Stain | Year | Notes |
12 | 14 | E, 2.1 Ch, 13 | Poor | P | Transverse | 10 | Al. carm. | 1893 | ||
164 | 18 | E, 3.5 Ch, 14 | Good | Formalin | P | Transverse | 20 | Al. carm. | 1913 | |
318 | 13/14 | E, 2.5 Ch, 16 | Good | P | Transverse | 25 | Al. carm. | 1905 | ||
470 | 17 | E, 4.3 Ch, 16 | Good | Formalin | P | Transverse | 10 | Al. carm. . | 1910 | |
779 | 14 | E, 2.75 | Good | C | Transverse | 15 | Al. coch. | 1913 | Dysraphism. Noted by Dekaban (1964)[1] | |
1182b | E, 3 Ch, 15x12x5 | Good | Formalin | ? | Transverse | 20 | Al. carm. | 1915 | ||
2053 | 20 | E, 3.1 Ch, 12 | Exc. | Formalin | P | Transverse | 10 | Al. coch. | 1918 | Most advanced in group. Ag added to slide 2 Monographs by Davis (1923)[2] and Congdon (1922)[3] |
4315 | 17 | E, 4.7 Ch, 23x10.4X11 | Excellent | ? | C-P | Transverse | 10 | I.H. & E. | 1923 | Univ. Chicago No. 951. Wen (1928)[4] |
4529 | 14 | E, 2.4 Ch, 21 | Excellent | Formalin | P | Transverse | 10 | Al. coch, or. G. | 1924 | Heuser (1930)[5] |
4783 | 13 | E, 2.3 | Fair | ? | ? | Transverse | 5 | I.H. | 1924 | Wallin (1913)[6] |
4877 | 13 | E, 2 Ch, 15 | Good | Formalin | P | Transverse | 15 | Al. coch. | 1925 | |
5072 | 17 | E, 3 | Good | Formalin | P | Transverse | 10 | (Stain - Haematoxylin Eosin) | 1925 | Tubal Type specimen. Atwell (1930)[7] |
6050 | 19/21 | E.,3 Ch, 10 | Good | Formalin | C-P | Coronal | 10 | Al. coch. | 1930 | Advanced |
6344 | 13 | E, 2.5 Ch, 17 | Excellent | Formalin | C-P | Transverse | 6 | Al. coch. | 1931 | Least advanced in group |
6784 | 17 | E, 5 Ch, 16 | Excellent | Formalin | C-P | Transverse | 6 | I.H, or. G. | 1933 | |
7358 | 16 | E, ? Ch, 15 | Poor | Alc, formol | p | Oblique | 25 | (Stain - Haematoxylin Eosin) | 1936 | |
7611 | 16 | E., 2.4 Ch., 12 | Excellent | Bouin | C-P | Transverse | 8 | (Stain - Haematoxylin Eosin) | 1938 | |
7665 | 19 | E., 4.36 | Excellent | ? | C-P | Transverse | 6 | 1939 | Univ. Chicago No. H 1516 | |
7702 | 17 | E, 3.7 Ch., 14 | Good | Formalin | C-P | Transverse | 10 | Al. coch. | 1940 | Returned to B M Patten |
7851 | 13 | E., 4.3 Ch, 18 | Excellent | Formalin | C-P | Transverse | 8 | (Stain - Haematoxylin Eosin) | 1940 | Slightly injured |
8005 | 16/17 | E, 3 | Excellent | Bouin | C-P | Transverse | 8 | (Stain - Haematoxylin Eosin) | 1942 | Tubal |
8116 | 17 | E, 14 Ch.. 17 | Good | Formalin | p | Sagittal | 8 | Azan | 1953 | |
8962 | 15 | E, 1.55 | Good | ? | * | Sagittal | ? | ? | 1952 | Tubal Univ. Chicago No. H 810 |
Abbreviations
| ||||||||||
References
|
Historic Embryology
Harvard Collection No. 714
- Harvard Collection No. 714 described by Bremer, J. L. 1906. Description of a 4-mm Human Embryo. Amer. J. Anat., 5, 459-480.
Keibel Collection Pfannenstiel III
Keibel F. and Elze C. Normal Plates of the Development of the Human Embryo (Homo sapiens). (1908) Vol. 8 in series by Keibel F. Normal plates of the development of vertebrates (Normentafeln zur Entwicklungsgeschichte der Wirbelthiere) Fisher, Jena., Germany. Shown as Embryo No.6 (Plate 1 fig. Vr. and Plate 2 fig. Vv.).
Low A. Description of a human embryo of 13-14 mesodermic somites. (1908) J Anat Physiol. 42(3): 237-51. PMID 17232769 | PMC1289161 Also described by Low in 1908.
Text-Book of Embryology (1921) Fig. 84
Chicago Collection H951
Wen IC. The anatomy of human embryos with seventeen to twenty-three pairs of somites (1928) J. Comp. Neural., 45: 301-376. H951 is a University of Chicago Collection 17 somite embryo.
Carnegie Collection
Low A. Description of a human embryo of 13-14 mesodermic somites. (1908) J Anat Physiol. 42(3): 237-51. PMID 17232769 | PMC1289161
Davis CL. Description of a human embryo having twenty paired somites. (1923) Carnegie Instn. Wash. Publ. 332, Contrib. Embryol., 15: 1-51.
Heuser CH. A human embryo with 14 pairs of somites. (1930) Carnegie Instn. Wash. Publ. 414, Contrib. Embryol., Carnegie Inst. Wash. 22:135-153.
Atwell WJ. A human embryo with seventeen pairs of somites. (1930) Contrib. Embryol., Carnegie Inst. Wash. Publ. 407, 21: 1-24.
Histology
Human embryo (CRL 4.2 mm) Blechschmidt Collection
Stage 11 histology links: optic pit | optic vesicle-hindbrain | neural tube roof plate 1 | neural tube roof plate 2
Events
- Cardiovascular - heart beating and peristaltic flow begins.[1]
- Hearing - at 16 somites the otic pit is formed and lies dorsal to the second pharyngeal groove (cleft).[2]
- Vision - right and left optic primordia meet at the optic chiasma forming a U-shaped rim.[3]
- Gastrointestinal - cloacal membrane is located on the ventral surface of the caudal part of the body wall, in a central oval depression.
References
- ↑ de Vries PA. and Saunders JBdeCH. Development of the ventricles and spiral outflow tract in the human heart. (1962) Carnegie Instn. Wash. Publ. 621, Contrib. Embryol., 37: 87-114.
- ↑ Bartelmez GW. and Evans HM. Development of the human embryo during the period of somite formation, including embryos with 2 to 16 pairs of somites. (1926) Contrib. Embryol., Carnegie Inst. Wash. Publ. 362, 17: 1-67.
- ↑ <pubmed>7364662</pubmed>
Additional References
<pubmed>2610025</pubmed> <pubmed>3826651</pubmed>
- Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline
Cite this page: Hill, M.A. (2024, April 19) Embryology Carnegie stage 11. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_stage_11
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G