Carnegie stage 10

Embryology - 25 Apr 2024 Expand to Translate
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Introduction

Facts

Week 4, 22 - 23 days, 2 - 3.5 mm, Somite number 4 - 12

Gestational Age GA - week 6

Features

Somite Number 4 - 12, rostral neuropore, neural folds in region of developing brain, neural tube, somites, caudal neuropore, neural fold fuses, remnant of amniotic sac

Summary

Ectoderm: Neural fold deeepens, edges approach midline, neural fold fuses, neural plate folds ventrally in brain region
Mesoderm: Somitogenesis, continued segmentation of paraxial mesoderm (4 - 12 somite pairs)

Identify

The rostral neuropore, neural folds in region of developing brain, neural tube, somites (note the different number formed), caudal neuropore, neural fold fuses, cut edge of amniotic sac.

Week:	1	2	3	4	5	6	7	8
Carnegie stage:	1 2 3 4	5 6	7 8 9	10 11 12 13	14 15	16 17	18 19	20 21 22 23

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Bright Field

Scanning EM

Image Source: Scanning electron micrographs of the Carnegie stages of the early human embryos are reproduced with the permission of Prof Kathy Sulik, from embryos collected by Dr. Vekemans and Tania Attié-Bitach. Images are for educational purposes only and cannot be reproduced electronically or in writing without permission.

Embryonic Development

Kyoto Collection

Facts: Week 4, 22 - 23 days, 2 - 3.5 mm, Somite Number 4 - 12

View: This is a dorsal view of the human embryo, the amniotic membrane has been removed. Top embryo is an early stage 10, bottom is late stage 10.

Early	Late

Stage 10 Embryo (12202) - transverse section
trilaminar embryo trilaminar embryo label lateral plate lateral plate label trilaminar embryo body trilaminar embryo body label

Image source: The Kyoto Collection images are reproduced with the permission of Prof. Kohei Shiota and Prof. Shigehito Yamada, Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan for educational purposes only and cannot be reproduced electronically or in writing without permission.

Carnegie Collection

Carnegie Collection - Stage 10
Serial No.	Pairs of somites	Size (mm)	Grade	Fixative	Embedding Medium	Thinness (µm)	Stain	Year	Notes
391	8	E, 2 Ch., 14	Good	Formalin	P	10	Al. coch.	1907	Monograph by Dandy (1910)^[1]
1201	7	E,2 Ch.. 144	Good	Formalin	P	8	H. & or. G.	1915	Univ. Chicago No. H 87
2795	4-5	E,2	Poor	Alc.	P	6	Al coch,or.G.	1919
3707	12	E, 1 5	Good	Formalin	P	12.5	I. H.	1921	Univ. Calif. No. H 197
3709	4	E. 1.4 Ch.. 14.8	Poor	Formalin	P	10	Erythrosin	1921	Univ. Chicago No H 279
3710	12	E., 3.6 Ch., 19.0	Good	Formalin	C-P	10	H. & or. G.	1921	Univ. Chicago No. H 392
4216	8	E, 2 Ch, 9.8	Good	Formalin	P	15	?	1923	Monograph by Payne (1925)^[2]
5074	10	E., 3.3 Ch., 10.8	Exc.	Bouin	P	10	Al. coch.	1925	Univ. Rochester No. H 10. Monograph by Corner (1929)^[3]
6330	7	E, 2.83	Good		P	5	Ehr. H.	1931	Univ. Chicago No. H 1404
6740	12	E., 2.2	Good	p	C-P	8	?	1933	Litzenberg embryo. Studied by Boyden (1940)
7251	8	E., 1.27	Good	Formalin	C-P	10	(Stain - Haematoxylin Eosin)	1941	"Singapore embryo." Univ. Cambridge No. H 98. Studied by Wilson (1914)^[4]
8244	6	E., 1.55 Ch, 8,5	Good	Alc.	C-P	8	(Stain - Haematoxylin Eosin) phlox.	1944
9870	12	Ch, ca. 8	Good	Zenker	P	5	Various, chiefly carmine	1952	Univ. Chicago. No. H 637. Dicephaly
Abbreviations Grade - total grade of the specimen and includes both its original quality and the condition of the mounted sections. Embedding medium - paraffin (P) or a combination of celloidin and paraffin (C-P). Fixative - formalin (Formol), alcohol and formalin (Alc, formol), Bouin (Bouin solution) ? - unknown or not determined. All Carnegie stage 10 embryos are cut in Transverse plane.

iBook - Carnegie Embryos
	iTunes link \| iBook Store Description - Imagine the excitement of seeing this incredible early period of human development for the first time. Now consider that much of our initial understanding of human development is based upon study of historic embryo collections. You can now look at these historic images of the first 8 weeks after fertilisation and explore for yourself the changes that occur in human development during this key period. This current book is designed as an atlas of the Carnegie embryo stages with some brief notes and additional information covering the first 8 weeks of development. These images are from from the beginning of last century and are one of the earliest documented series of human embryos collected for basic research and medical education on development. I hope you enjoy learning about the amazing early events that begin to make and shape us. This is the second book in a series of educational releases from UNSW Embryology. Release: First Edition - Mar 12, 2012 ISBN 978-0-7334-3148-7 Print Length 82 Pages, 25.8 MB Language English. PDF Preview version 3.87 MB (Read the associated information, this is an edited educational preview version with many features not functioning). The current website also includes numerous embryo images from this textbook (see Embryonic Development and Carnegie Embryos).

Events

For a detailed description of the stage 10 human embryos see the papers published 1910^[1], 1929, ^[5], 1939 ^[6], review by Heuser in 1957^[7] and in chapter by O'Rahilly and Müller in 1987.^[8]

Hearing - 10 somites first indication of otic placode invagination^[5] 12 somites cells migrate from the otic disc.^[9]
Vision - optic primordia appear.^[10]