Carnegie Stage 8 - "Dobbin" Embryo: Difference between revisions

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{{Header}}
{{Header}}
==Introduction==
==Introduction==
[[File:James Hill.jpg|thumb|alt=James Hill|link=Embryology History - James Hill|James Hill (1873 - 1954)]]
[[File:HillH159 Stage 8 bf01.jpg|thumb|Photograph of intact chorionic vesicle.]]


The "Dobbin" embryo was named after Dr Roy Dobbin (Cairo, Egypt) who originally provided the specimen to [[Embryology_History_-_James Hill|Dr James Hill]].
The historic "Dobbin" embryo was named after Dr Roy Dobbin (Cairo, Egypt) who originally provided the specimen to [[Embryology_History_-_James Hill|Dr James Hill]].


This [[Carnegie stage 8]] human embryo was 960 µm long and was subsequently serially sectioned and published in a series of papers by [[Embryology_History_-_James Hill|James Hill]] and [[:Category:Jan Florian|Jan Florian]] and during the 1930's.<ref name=Hill1931a>{{Ref-Hill1931a}}</ref><ref name=Hill1931b>{{Ref-Hill1931b}}</ref><ref name=Hill1931c>{{Ref-Hill1931c}}</ref>
This [[Carnegie stage 8]] human embryo was 960 µm long and was subsequently serially sectioned and published in a series of papers by [[Embryology_History_-_James Hill|James Hill]] and [[:Category:Jan Florian|Jan Florian]] and during the 1930's.<ref name=Hill1931a>{{Ref-Hill1931a}}</ref><ref name=Hill1931b>{{Ref-Hill1931b}}</ref><ref name=Hill1931c>{{Ref-Hill1931c}}</ref>


The notes, photographs and sections form part of the embryological collection held
The notes, photographs and sections are within the  [[Hill Collection]] that form a part of the embryological collection relocated in 2004 to the Museum fur Naturkunde, Berlin and incorporated with the [[Hubrecht Collection]].
 
 
 
:'''Links:''' [[:Category:Hill Embryo H91|Hill Embryo H91]] | [[Carnegie stage 8]] | [[Hill Collection]] | [[Embryology_History_-_James Hill|Dr James Hill]] | [[Hubrecht Collection]] | [http://www.naturkundemuseum-berlin.de/en/sammlungen/zoologie/embryologische-sammlung  Museum fur Naturkunde - Embryological Collection]
 


{{Embryo Collections}}
{{Embryo Collections}}
==Description==
The clinical history supplied by Dr. Dobbin is as follows: “ Coitus, 6.10.23 ; effort probably causing abortion, 21.10.23; first bleeding, 22.10.23; abortion (painless), 23.10.23." Although an abortion, we see no reason to regard the specimen as other than perfectly normal.


The chorionic vesicle (which was preserved in spirit) was, when received, somewhat flattened and shrunken. Except over a small area on one side (approximately 3 x 2 mm in diameter), which was almost bare, the vesicle possessed a fairly uniform covering of short, close~set, branched villi, to which at one point a small fragment of blood-clot adhered. Including the villi, its dimensions in alcohol were as follows : 11.5 mm (in long diameter) x 8.5 mm (in short diameter) x 45 mm (in thickness). After clearing in oil of cedar-wood, the corresponding internal diameters were 9 mm x 5.5 mm x 2.5 mm.
The vesicle, after being photographed and drawn, was dehydrated and cleared in oil of cedar-wood. A small portion of the chorion, including the bare area, was then carefully removed, and through the opening so made it was possible, fortunately enough, to locate the embryo under the binocular dissecting microscope. The embryo was then isolated along with the segment of the chorion to which it was attached, and stereo-photographs were successfully taken of it, in the cleared condition in oil of cedar-wood.
'''Hill catalogue number''' - (original) H159 | (new) [[:Category:Hill Embryo H91|H91]]
The original embryology catalogue numbers were consolidated and renumbered by Peter Hill's daughter, another embryologist.
==Embryo - Chorionic Vesicle==
These are stereo photographs of the whole and opened vesicle before sectioning.
{|
! Whole vesicle
|-
| [[File:HillH159 Stage 8 bf01.jpg|400px]]
| [[File:HillH159 Stage 8 bf02.jpg|400px]]
|-
! Opened vesicle
|-
| [[File:HillH159 Stage 8 bf03.jpg|400px]]
| [[File:HillH159 Stage 8 bf04.jpg|400px]]
|}


{{Dobbin table}}
{{Dobbin table}}
==Histology==
<gallery>
File:HillH91 Stage8 slide2 47.jpg|2-47
File:HillH91 Stage8 slide2 48.jpg|2-48
File:HillH91 Stage8 slide2 49.jpg|2-49
File:HillH91 Stage8 slide2 50.jpg|2-50
File:HillH91 Stage8 slide2 51.jpg|2-51
File:HillH91 Stage8 slide2 52.jpg|2-52
File:HillH91 Stage8 slide2 53.jpg|2-53
File:HillH91 Stage8 slide2 54.jpg|2-54
File:HillH91 Stage8 slide2 55.jpg|2-55
File:HillH91 Stage8 slide2 56.jpg|2-56
File:HillH91 Stage8 slide2 57.jpg|2-57
File:HillH91 Stage8 slide2 70.jpg|2-70
File:HillH91 Stage8 slide2 75.jpg|2-75
File:HillH91 Stage8 slide2 80.jpg|2-80
File:HillH91 Stage8 slide2 89.jpg|2-89
</gallery>
{{HillH91 histology}}


==References==
==References==
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{{Footer}}
{{Footer}}
[[Category:1903's]][[Category:Carnegie Stage 8]]
[[Category:1930's]][[Category:Hill Embryo H91]][[Category:Carnegie Stage 8]][[Category:Hill Collection]][[Category:James Hill]]

Latest revision as of 20:03, 26 August 2016

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Introduction

James Hill
James Hill (1873 - 1954)
Photograph of intact chorionic vesicle.

The historic "Dobbin" embryo was named after Dr Roy Dobbin (Cairo, Egypt) who originally provided the specimen to Dr James Hill.

This Carnegie stage 8 human embryo was 960 µm long and was subsequently serially sectioned and published in a series of papers by James Hill and Jan Florian and during the 1930's.[1][2][3]

The notes, photographs and sections are within the Hill Collection that form a part of the embryological collection relocated in 2004 to the Museum fur Naturkunde, Berlin and incorporated with the Hubrecht Collection.


Links: Hill Embryo H91 | Carnegie stage 8 | Hill Collection | Dr James Hill | Hubrecht Collection | Museum fur Naturkunde - Embryological Collection


Embryo Collections: Human Embryo Collections | Embryo Collections | Blechschmidt Collection | Carnegie Collection | Domenech-Mateu Collection | Harvard Collection | Hill Collection | Hinrichsen Collection | Hubrecht Collection | Kyoto Collection | Madrid Collection | Embryology Models | DEC Information | DEC

Description

The clinical history supplied by Dr. Dobbin is as follows: “ Coitus, 6.10.23 ; effort probably causing abortion, 21.10.23; first bleeding, 22.10.23; abortion (painless), 23.10.23." Although an abortion, we see no reason to regard the specimen as other than perfectly normal.


The chorionic vesicle (which was preserved in spirit) was, when received, somewhat flattened and shrunken. Except over a small area on one side (approximately 3 x 2 mm in diameter), which was almost bare, the vesicle possessed a fairly uniform covering of short, close~set, branched villi, to which at one point a small fragment of blood-clot adhered. Including the villi, its dimensions in alcohol were as follows : 11.5 mm (in long diameter) x 8.5 mm (in short diameter) x 45 mm (in thickness). After clearing in oil of cedar-wood, the corresponding internal diameters were 9 mm x 5.5 mm x 2.5 mm.

The vesicle, after being photographed and drawn, was dehydrated and cleared in oil of cedar-wood. A small portion of the chorion, including the bare area, was then carefully removed, and through the opening so made it was possible, fortunately enough, to locate the embryo under the binocular dissecting microscope. The embryo was then isolated along with the segment of the chorion to which it was attached, and stereo-photographs were successfully taken of it, in the cleared condition in oil of cedar-wood.

Hill catalogue number - (original) H159 | (new) H91

The original embryology catalogue numbers were consolidated and renumbered by Peter Hill's daughter, another embryologist.

Embryo - Chorionic Vesicle

These are stereo photographs of the whole and opened vesicle before sectioning.

Whole vesicle
HillH159 Stage 8 bf01.jpg HillH159 Stage 8 bf02.jpg
Opened vesicle
HillH159 Stage 8 bf03.jpg HillH159 Stage 8 bf04.jpg
"Dobbin" Embryo  
Further descriptions of the "Dobbin" Embryo characterised as (Carnegie Stage 8) can be found in the following papers:

Hill JP. and Florian J. The development of head-process and prochordal plate in man (1931) J Anat. 65(2): 242-6. PMID 17104317

Hill JP. and Florian J. A young human embryo (embryo dobbin) with head-process and prochordal plate. (1931) Phil. Tran. Roy. Soc. London B, 219: 443-486.

Hill JP. and Florian J. Further note on the pro-chordal plate in man. (1931) J. Anat., 46: 46-47. PMID 17104356

Note the rostral end of notochordal process was at first mistaken for prechordal plate, see published correction.

See page - Carnegie Stage 8 - "Dobbin" Embryo


Stage 8 Links: Week 3 | Gastrulation | Lecture | Lecture | Somitogenesis | Lecture - Mesoderm | Lecture - Ectoderm | Lecture - Early Vascular | Science Practical | Carnegie Embryos | Category:Carnegie Stage 8 | Next Stage 9
  Historic Papers: 1920 Mateer Embryo | 1931 Head-Process | 1931 Prochordal Plate | 1931 neurenteric canal

Histology


Transverse section, scale bar is 500 micron.

Links: "Dobbin" Embryo | Hill Embryo H91 | Carnegie stage 8 | Hill Collection
Histology Slide: 2-47 | 2-48 | 2-49 | 2-50 | 2-51 | 2-52 | 2-53 | 2-54 | 2-55 | 2-56 | 2-57 | 2-70 | 2-75 | 2-80 | 2-89

References

  1. Hill JP. and Florian J. The development of head-process and prochordal plate in man (1931) J Anat. 65(2): 242-6. PMID 17104317
  2. Hill JP. and Florian J. A young human embryo (embryo dobbin) with head-process and prochordal plate. (1931) Phil. Tran. Roy. Soc. London B, 219: 443-486.
  3. Hill JP. and Florian J. Further note on the pro-chordal plate in man. (1931) J. Anat., 46: 46-47. PMID 17104356



Cite this page: Hill, M.A. (2024, March 28) Embryology Carnegie Stage 8 - "Dobbin" Embryo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Carnegie_Stage_8_-_%22Dobbin%22_Embryo

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G