Introduction
The embryo stage 10 heart tube
Development of the heart and vascular system begins very early in mesoderm both within (embryonic) and outside (extra embryonic, yolk sac and placental) the embryo. Vascular development therefore occurs in many places, the most obvious though is the early forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo. The cardiovascular system is extensively remodelled throughout development, this current page only introduces topic.
The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.
Throughout the mesoderm, small regions differentiate into "blood islands" which contribute both blood vessels (walls) and fetal red blood cells.
These "islands" connect together to form the first vessels which connect with the heart tube.
A detailed description of heart development is covered in the Online Heart Tutorial.
Some Recent Findings
- A detailed comparison of mouse and human cardiac development[1] "Episcopic fluorescence image capture (EFIC) was performed on 66 wild-type mouse embryos from embryonic day (E) 9.5 to birth; 2-dimensional and 3-dimensional datasets were compared with EFIC and magnetic resonance images from a study of 52 human fetuses (Carnegie stage 13-23). Time course of atrial, ventricular, and outflow septation were outlined and followed a similar sequence in both species. Bilateral venae cavae and prominent atrial appendages were seen in the mouse fetus; in human fetuses, atrial appendages were small, and a single right superior vena cava was present. In contrast to humans with separate pulmonary vein orifices, a pulmonary venous confluence with one orifice enters the left atrium in mice. The cardiac developmental sequences observed in mouse and human fetuses are comparable, with minor differences in atrial and venous morphology. These comparisons of mouse and human cardiac development strongly support that mouse morphogenesis is a good model for human development." Mouse Development | Kyoto Collection
- Assembly of the Cardiac Intercalated Disk during Pre- and Postnatal Development of the Human Heart[2] "In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provides as a macromolecular infrastructure that integrates mechanical and electrical coupling within the heart. ...Our data on developmental maturation of the ID in human heart indicate that generation of the mechanical junctions at the ID precedes that of the electrical junctions with a significant difference in time. In addition arrival of the electrical junctions (Nav1.5 and Cx43) is not uniform since sodium channels localize much earlier than gap junction channels."
- Endothelial cell lineages of the heart. [3] "During early gastrulation, vertebrate embryos begin to produce endothelial cells (ECs) from the mesoderm. ECs first form primitive vascular plexus de novo and later differentiate into arterial, venous, capillary, and lymphatic ECs. In the heart, the five distinct EC types (endocardial, coronary arterial, venous, capillary, and lymphatic) have distinct phenotypes. For example, coronary ECs establish a typical vessel network throughout the myocardium, whereas endocardial ECs form a large epithelial sheet with no angiogenic sprouting into the myocardium. Neither coronary arteries, veins, and capillaries, nor lymphatic vessels fuse with the endocardium or open to the heart chamber. The developmental stage during which the specific phenotype of each cardiac EC type is determined remains unclear. The mechanisms involved in EC commitment and diversity can however be more precisely defined by tracking the migratory patterns and lineage decisions of the precursors of cardiac ECs."
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More recent papers
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Textbooks
- Human Embryology (2nd ed.) Larson Ch7 p151-188 Heart, Ch8 p189-228 Vasculature
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Ch14: p304-349
- Before we Are Born (5th ed.) Moore and Persaud Ch12; p241-254
- Essentials of Human Embryology Larson Ch7 p97-122 Heart, Ch8 p123-146 Vasculature
- Human Embryology Fitzgerald and Fitzgerald Ch13-17: p77-111
Heart Tutorial
Timecourse
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The Human Heart from day 10 to 25 (scanning electron micrograph)
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- Forms initially in splanchnic mesoderm of prechordal plate region - cardiogenic region
- growth and folding of the embryo moves heart ventrally and downward into anatomical position
- Day 22 - 23, begins to beat in humans
- heart tube connects to blood vessels forming in splanchnic and extraembryonic mesoderm
- Week 2 - 3 pair of thin-walled tubes
- Week 3 paired heart tubes fuse, truncus arteriosus outflow, heart contracting
- Week 4 heart tube continues to elongate, curving to form S shape
- Week 5 Septation starts]], atrial and ventricular
- Septation continues, atrial septa remains open, foramen ovale
- Week 37-38 At birth, pressure difference closes foramen ovale leaving a fossa ovalis
Heart Development Movies
Animations
Animations showing aspects of heart development.
Tutorials
Pages within the online Cardiac tutorial.
Historic
Historic animations including audio descriptions. Some of these descriptions may be currently inaccurate, the transfer is from an old class film and the audio track is of very poor quality.
About Historic Animations
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Animations are modified and converted from a historic film (circa 1960's, copyright unknown) demonstrating aspects of human heart development.
The sound quality is quite poor and some of the information is now out of date, most general concepts are still correct.
Please note the relatively large size (Mb) of each excerpt will effect download and viewing.
March 2013
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Septation Models
Ventricular septation rotation models.
Chicken Heart Development
Note the images of chicken heart development[4] shown below are Hamburger Hamilton Stages of chicken development, not Carnegie stages. See also Heart 3D reconstruction.
Chicken (day 2, Stage 12)
Chicken (day 3, Stage 16)
Chicken (day 4, Stage 21)
Chicken (day 5, Stage 25)
Pharyngeal Arch Arteries
In the head region of the embryo, each pharyngeal arch initially has paired arch arteries. These are extensively remodelled through development and give rise to a range of different arterial structures, as shown in the list below.
- Arch 1 - mainly lost, form part of maxillary artery.
- Arch 2 - stapedial arteries.
- Arch 3 - common carotid arteries, internal carotid arteries.
- Arch 4 - left forms part of aortic arch, right forms part right subclavian artery.
- Arch 6 - left forms part of left pulmonary artery , right forms part of right pulmonary artery.
- Links: Head Development
Renal Venous Development
The renal arterial and venous systems are also reorganised extensively throughout development with changing kidney position.
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Embryo renal venous
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Adult renal venous
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- Links: Renal Development
Fetal Blood Flow
Mean Late Fetal Blood Flows[5]
(8 subjects) in the major vessels of the human fetal circulation by phase contrast MRI. (median gestational age 37 weeks, age range of 30–39 weeks)
(left) Mean flows in ml/kg/min
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(right) Proportions of the combined ventricular output in the major vessels of the human fetal circulation by phase contrast MRI.
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- AAo - Ascending aorta
- MPA - main pulmonary artery
- DA - ductus arteriosus
- PBF - pulmonary blood flow
- DAo - descending aorta
- UA - umbilical artery
- UV - umbilical vein
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- IVC - inferior vena cava
- SVC - superior vena cava
- RA - right atrium
- FO - foramen ovale
- LA - left atrium
- RV - right ventricle
- LV - left ventricle
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- Cardiovascular Links: Fetal Blood Flow values | Mean Fetal Blood Flow | Proportions Ventricular Output | Ventricular Output (colour) | heart | blood | cardiovascular
References
Reviews
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Articles
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- Cardiovascular System Development All (63457) Review (10735) Free Full Text (15717)
Search Pubmed: Cardiovascular System Development
Additional Images
See also Category:Heart ILP and Category:Heart
Ziegler Models
Heart Development Timeline
Early Heart Tube (Dorsal)
Early Heart Tube (Lateral)
Molecular & Genetic Cardiac Development Factors
Adult heart blood flow cartoon
Adult human cardiovascular system cartoon
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
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Cite this page: Hill, M.A. (2024, April 23) Embryology Cardiovascular System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_Development
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- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G