Cardiovascular System Development: Difference between revisions

Revision as of 13:23, 20 April 2012

Introduction

The embryo stage 10 heart tube

Development of the heart and vascular system begins very early in mesoderm both within (embryonic) and outside (extra embryonic, yolk sac and placental) the embryo. Vascular development therefore occurs in many places, the most obvious though is the early forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo. The cardiovascular system is extensively remodelled throughout development, this current page only introduces topic.

The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.

Throughout the mesoderm, small regions differentiate into "blood islands" which contribute both blood vessels (walls) and fetal red blood cells.

These "islands" connect together to form the first vessels which connect with the heart tube.

A detailed description of heart development is covered in the Online Heart Tutorial.

Historic Embryology - Cardiovascular
1902 Vena cava inferior \| 1905 Brain Blood Vessels \| 1909 Cervical Veins \| 1909 Dorsal aorta and umbilical veins \| 1912 Heart \| 1912 Human Heart \| 1914 Earliest Blood-Vessels \| 1915 Congenital Cardiac Disease \| 1915 Dura Venous Sinuses \| 1916 Blood cell origin \| 1916 Pars Membranacea Septi \| 1919 Lower Limb Arteries \| 1921 Human Brain Vascular \| 1921 Spleen \| 1922 Aortic-Arch System \| 1922 Pig Forelimb Arteries \| 1922 Chicken Pulmonary \| 1923 Head Subcutaneous Plexus \| 1923 Ductus Venosus \| 1925 Venous Development \| 1927 Stage 11 Heart \| 1928 Heart Blood Flow \| 1935 Aorta \| 1935 Venous valves \| 1938 Pars Membranacea Septi \| 1938 Foramen Ovale \| 1939 Atrio-Ventricular Valves \| 1940 Vena cava inferior \| 1940 Early Hematopoiesis \| 1941 Blood Formation \| 1942 Truncus and Conus Partitioning \| Ziegler Heart Models \| 1951 Heart Movie \| 1954 Week 9 Heart \| 1957 Cranial venous system \| 1959 Brain Arterial Anastomoses \| Historic Embryology Papers \| 2012 ECHO Meeting \| 2016 Cardiac Review \| Historic Disclaimer

Some Recent Findings

Endothelial cell lineages of the heart. ^[1] "During early gastrulation, vertebrate embryos begin to produce endothelial cells (ECs) from the mesoderm. ECs first form primitive vascular plexus de novo and later differentiate into arterial, venous, capillary, and lymphatic ECs. In the heart, the five distinct EC types (endocardial, coronary arterial, venous, capillary, and lymphatic) have distinct phenotypes. For example, coronary ECs establish a typical vessel network throughout the myocardium, whereas endocardial ECs form a large epithelial sheet with no angiogenic sprouting into the myocardium. Neither coronary arteries, veins, and capillaries, nor lymphatic vessels fuse with the endocardium or open to the heart chamber. The developmental stage during which the specific phenotype of each cardiac EC type is determined remains unclear. The mechanisms involved in EC commitment and diversity can however be more precisely defined by tracking the migratory patterns and lineage decisions of the precursors of cardiac ECs."

Textbooks

Cardiac_muscle_histology

Human Embryology (2nd ed.) Larson Ch7 p151-188 Heart, Ch8 p189-228 Vasculature
The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Ch14: p304-349
Before we Are Born (5th ed.) Moore and Persaud Ch12; p241-254
Essentials of Human Embryology Larson Ch7 p97-122 Heart, Ch8 p123-146 Vasculature
Human Embryology Fitzgerald and Fitzgerald Ch13-17: p77-111

Timecourse

The Human Heart from day 10 to 25 (scanning electron micrograph)

Forms initially in splanchnic mesoderm of prechordal plate region - cardiogenic region
- growth and folding of the embryo moves heart ventrally and downward into anatomical position
Day 22 - 23, begins to beat in humans
- heart tube connects to blood vessels forming in splanchnic and extraembryonic mesoderm
Week 2 - 3 pair of thin-walled tubes
Week 3 paired heart tubes fuse, truncus arteriosus outflow, heart contracting
Week 4 heart tube continues to elongate, curving to form S shape
Week 5 Septation starts, atrial and ventricular
- Septation continues, atrial septa remains open, foramen ovale
Week 37-38 At birth, pressure difference closes foramen ovale leaving a fossa ovalis

Heart Development Movies

Animations showing aspects of heart development.


Heart Looping	Heart Realign	Heart Atrial Septation	Heart Outflow Septation


Stage 13	Stage 22

Pages within the online Cardiac tutorial.


Heart Fields	Primitive Heart Tube	Heart Tubes	Cardiac Looping	Cardiac Septation	Outflow Tract

Historic animations including audio descriptions. Some of these descriptions may be currently inaccurate, the transfer is from an old class film and the audio track is of very poor quality.


Part 1	Part 2	Part 3	Part 4

Part 5	Part 6	Part 7	Part 8

Ventricular septation rotation models.


Part 1	Part 2	Part 3

Chicken Heart Development

Note the images of chicken heart development^[2] shown below are Hamburger Hamilton Stages of chicken development, not Carnegie stages. See also Heart 3D reconstruction.

Chicken (day 2, Stage 12)
Chicken (day 3, Stage 16)
Chicken (day 4, Stage 21)
Chicken (day 5, Stage 25)

Pharyngeal Arch Arteries

In the head region of the embryo, each pharyngeal arch initially has paired arch arteries. These are extensively remodelled through development and give rise to a range of different arterial structures, as shown in the list below.

Arch 1 - mainly lost, form part of maxillary artery.
Arch 2 - stapedial arteries.
Arch 3 - common carotid arteries, internal carotid arteries.
Arch 4 - left forms part of aortic arch, right forms part right subclavian artery.
Arch 6 - left forms part of left pulmonary artery , right forms part of right pulmonary artery.

Links: Head Development

Renal Venous Development

The renal arterial and venous systems are also reorganised extensively throughout development with changing kidney position.


Embryo renal venous	Adult renal venous

Links: Renal Development

References

↑ <pubmed>18682987</pubmed>
↑ <pubmed>21779373</pubmed>| PLoS One

Reviews

Articles

Search Pubmed

Search May 2010

Cardiovascular System Development All (63457) Review (10735) Free Full Text (15717)

Search Pubmed: Cardiovascular System Development

Additional Images

See also Category:Heart ILP and Category:Heart

Historic image
Heart Development Timeline
Human heart SEM
Early Heart Tube (Dorsal)
Early Heart Tube (Lateral)
Heart Tube Segments
Heart Looping Sequence
Molecular & Genetic Cardiac Development Factors
Adult heart blood flow cartoon
Adult human cardiovascular system cartoon

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

USA National Heart, Lung, and Blood Institute - Congenital Heart Defects | Heart and Vascular Information

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, April 16) Embryology Cardiovascular System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_Development

What Links Here?

[1] <pubmed>18682987</pubmed>

[2] <pubmed>21779373</pubmed>| PLoS One

[1]

[2]

@@ Line 153: / Line 153: @@
 ==Pharyngeal Arch Arteries==
+[[File:Stage 13 image 058.jpg|Pharyngeal arch arteries]]
 In the head region of the embryo, each pharyngeal arch initially has paired arch arteries. These are extensively remodelled through development and give rise to a range of different arterial structures, as shown in the list below.