Cardiovascular System - Heart Development: Difference between revisions

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<nowiki>*</nowiki> Table data is "embryonic age" while original reference used "gestational age" (from LMP)(Data: [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16388511 Peralta CF, Cavoretto P, Csapo B, Falcon O, Nicolaides KH.] Lung and heart volumes by three-dimensional ultrasound in normal fetuses at 12-32 weeks' gestation. Ultrasound Obstet Gynecol. 2006 Feb;27(2):128-33.)
Table data is "embryonic age" while original reference used gestational age {{GA}} (from LMP)<ref name=PMID16388511><pubmed>16388511</pubmed></ref>
 
'''Stroke Volume'''  
'''Stroke Volume'''  


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<nowiki>*</nowiki>  Table data is "embryonic age" while original reference used "gestational age" (from LMP). The stroke volume (SV) can be calculated from ultrasound measurement of end diastole volume (EDV) minus end systole volume (ESV); (SV = EDV - ESV). (Data: [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18634132 Molina FS, Faro C, Sotiriadis A, Dagklis T, Nicolaides KH.] Heart stroke volume and cardiac output by four-dimensional ultrasound in normal fetuses. Ultrasound Obstet Gynecol. 2008 Aug;32(2):181-7.
Table data is "embryonic age" while original reference used gestational age {{GA}} (from LMP) The stroke volume (SV) can be calculated from ultrasound measurement of end diastole volume (EDV) minus end systole volume (ESV); (SV = EDV - ESV).  
 
(Data: [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18634132 Molina FS, Faro C, Sotiriadis A, Dagklis T, Nicolaides KH.] Heart stroke volume and cardiac output by four-dimensional ultrasound in normal fetuses. Ultrasound Obstet Gynecol. 2008 Aug;32(2):181-7.


==Additional Images==
==Additional Images==

Revision as of 15:06, 25 May 2016

Embryology - 28 Mar 2024    Facebook link Pinterest link Twitter link  Expand to Translate  
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Introduction

Human embryo heart (day 54 - 56)
The best place for students to start is the Heart Tutorial.


In human embryos the heart begins to beat at about 22-23 days, with blood flow beginning in the 4th week. The heart is therefore one of the earliest differentiating and functioning organs.

The heart begins very early in mesoderm within the trilaminar embryonic disc. The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.

A key aspect of heart development is the septation of the heart into separate chambers. As the embryonic/fetal circulation is different to the neonatal circulation (lung/pulmonary activation), several defects of heart septation may only become apparent on this transition. One septal "defect" occurs in us all, the foramen ovale (between the 2 atria) which in general closes in the neonate over time.

Embryonic Heart Rate (EHR), early in development the heart starts to spontaneously beat and a recent study by Wisser and Dirschedl in dated human embryos showed an increase up to 63 postmenstrual days or 22 mm greatest length. Thereafter a steady decrease of EHR was noted. Maximal EHR is reached when morphological development of the embryonic heart is completed.


Heart Tutorial

Basic Heart

Basic Heart Development Timeline.jpg

Advanced Heart

Advanced Heart Development Timeline GA.jpg

Cardiovascular Links: cardiovascular | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | 2016 Cardiac Review | heart | coronary circulation | heart valve | heart rate | Circulation | blood | blood vessel | blood vessel histology | heart histology | Lymphatic | ductus venosus | spleen | Stage 22 | cardiovascular abnormalities | OMIM | 2012 ECHO Meeting | Category:Cardiovascular
Historic Embryology - Cardiovascular 
1902 Vena cava inferior | 1905 Brain Blood Vessels | 1909 Cervical Veins | 1909 Dorsal aorta and umbilical veins | 1912 Heart | 1912 Human Heart | 1914 Earliest Blood-Vessels | 1915 Congenital Cardiac Disease | 1915 Dura Venous Sinuses | 1916 Blood cell origin | 1916 Pars Membranacea Septi | 1919 Lower Limb Arteries | 1921 Human Brain Vascular | 1921 Spleen | 1922 Aortic-Arch System | 1922 Pig Forelimb Arteries | 1922 Chicken Pulmonary | 1923 Head Subcutaneous Plexus | 1923 Ductus Venosus | 1925 Venous Development | 1927 Stage 11 Heart | 1928 Heart Blood Flow | 1935 Aorta | 1935 Venous valves | 1938 Pars Membranacea Septi | 1938 Foramen Ovale | 1939 Atrio-Ventricular Valves | 1940 Vena cava inferior | 1940 Early Hematopoiesis | 1941 Blood Formation | 1942 Truncus and Conus Partitioning | Ziegler Heart Models | 1951 Heart Movie | 1954 Week 9 Heart | 1957 Cranial venous system | 1959 Brain Arterial Anastomoses | Historic Embryology Papers | 2012 ECHO Meeting | 2016 Cardiac Review | Historic Disclaimer

Textbooks

UNSW Embryology

UNSW Embryology logo
Hill, M.A. (2020). UNSW Embryology (20th ed.) Retrieved March 28, 2024, from https://embryology.med.unsw.edu.au
Cardiovascular Links: cardiovascular | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | 2016 Cardiac Review | heart | coronary circulation | heart valve | heart rate | Circulation | blood | blood vessel | blood vessel histology | heart histology | Lymphatic | ductus venosus | spleen | Stage 22 | cardiovascular abnormalities | OMIM | 2012 ECHO Meeting | Category:Cardiovascular
Historic Embryology - Cardiovascular 
1902 Vena cava inferior | 1905 Brain Blood Vessels | 1909 Cervical Veins | 1909 Dorsal aorta and umbilical veins | 1912 Heart | 1912 Human Heart | 1914 Earliest Blood-Vessels | 1915 Congenital Cardiac Disease | 1915 Dura Venous Sinuses | 1916 Blood cell origin | 1916 Pars Membranacea Septi | 1919 Lower Limb Arteries | 1921 Human Brain Vascular | 1921 Spleen | 1922 Aortic-Arch System | 1922 Pig Forelimb Arteries | 1922 Chicken Pulmonary | 1923 Head Subcutaneous Plexus | 1923 Ductus Venosus | 1925 Venous Development | 1927 Stage 11 Heart | 1928 Heart Blood Flow | 1935 Aorta | 1935 Venous valves | 1938 Pars Membranacea Septi | 1938 Foramen Ovale | 1939 Atrio-Ventricular Valves | 1940 Vena cava inferior | 1940 Early Hematopoiesis | 1941 Blood Formation | 1942 Truncus and Conus Partitioning | Ziegler Heart Models | 1951 Heart Movie | 1954 Week 9 Heart | 1957 Cranial venous system | 1959 Brain Arterial Anastomoses | Historic Embryology Papers | 2012 ECHO Meeting | 2016 Cardiac Review | Historic Disclaimer


Heart Tutorial | 2013 Lecture Slides

The Developing Human: Clinically Oriented Embryology

Textbook cover The Developing Human, 9th edn.
Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2011). The developing human: clinically oriented embryology (9th ed.). Philadelphia: Saunders.
(links available to UNSW students)

Larsen's Human Embryology

Textbook cover Larsen's human embryology 4th edn.
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. & Francis-West, P.H. (2009). Larsen's human embryology (4th ed.). New York; Edinburgh: Churchill Livingstone.
(links available to UNSW students)
Links: Embryology Textbooks
  • Human Embryology (2nd ed.) Larson Ch7 p151-188 Heart
  • The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Ch14: p304-349
  • Before we Are Born (5th ed.) Moore and Persaud Ch12; p241-254
  • Essentials of Human Embryology Larson Ch7 p97-122 Heart
  • Human Embryology Fitzgerald and Fitzgerald Ch13-17: p77-111
Links: Embryology Textbooks

Movies

Cardiovascular System Development | Heart Tutorial

Week3 folding icon.jpg
 ‎‎Week 3
Page | Play
Heart1 looping icon.jpg
 ‎‎Heart Looping
Page | Play
Heart1 realign icon.jpg
 ‎‎Heart Realign
Page | Play
Heart1 atrium icon.jpg
 ‎‎Atrial Septation
Page | Play
Heart1 ventricle icon.jpg
 ‎‎Outflow Septation
Page | Play


Heart Cartoons
Heart fields 001 icon.jpg
 ‎‎Heart Fields
Page | Play
Heart folding 002 icon.jpg
 ‎‎Primitive Heart Tube
Page | Play
Heart folding 001 icon.jpg
 ‎‎Heart Tubes
Page | Play
Heart looping 006 icon.jpg
 ‎‎Cardiac Looping
Page | Play
Heart septation 003 icon.jpg
 ‎‎Cardiac Septation
Page | Play
Heart septation 001 icon.jpg
 ‎‎Cardiac Septation
Page | Play
Outflow tract 001 icon.jpg
 ‎‎Outflow Tract
Page | Play


Heart-ventricular-septum-01.jpg
 ‎‎Ventricular Septum 1
Page | Play
Heart-ventricular-septum-02.jpg
 ‎‎Ventricular Septum 2
Page | Play
Heart-ventricular-septum-03.jpg
 ‎‎Ventricular Septum 3
Page | Play
Historic Animations
Heart historic 001 icon.jpg
 ‎‎Anatomy
Page | Play
Heart historic 002 icon.jpg
 ‎‎Week 3
Page | Play
Heart historic 003 icon.jpg
 ‎‎Week 3-5
Page | Play
Heart historic 004 icon.jpg
 ‎‎Week 4-11
Page | Play
Heart historic 005 icon.jpg
 ‎‎Embryo overview
Page | Play
Heart historic 006 icon.jpg
 ‎‎AV Septation
Page | Play
Heart historic 007 icon.jpg
 ‎‎Outflow Septation
Page | Play
Heart historic 008 icon.jpg
 ‎‎Valve+Overview
Page | Play
About Historic Animations
Mark Hill.jpg
Animations are modified and converted from a historic film (circa 1960's, copyright unknown) demonstrating aspects of human heart development.

The sound quality is quite poor and some of the information is now out of date, most general concepts are still correct.

Please note the relatively large size (Mb) of each excerpt will effect download and viewing.

March 2013

Cardiovascular Links: cardiovascular | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | 2016 Cardiac Review | heart | coronary circulation | heart valve | heart rate | Circulation | blood | blood vessel | blood vessel histology | heart histology | Lymphatic | ductus venosus | spleen | Stage 22 | cardiovascular abnormalities | OMIM | 2012 ECHO Meeting | Category:Cardiovascular
Historic Embryology - Cardiovascular 
1902 Vena cava inferior | 1905 Brain Blood Vessels | 1909 Cervical Veins | 1909 Dorsal aorta and umbilical veins | 1912 Heart | 1912 Human Heart | 1914 Earliest Blood-Vessels | 1915 Congenital Cardiac Disease | 1915 Dura Venous Sinuses | 1916 Blood cell origin | 1916 Pars Membranacea Septi | 1919 Lower Limb Arteries | 1921 Human Brain Vascular | 1921 Spleen | 1922 Aortic-Arch System | 1922 Pig Forelimb Arteries | 1922 Chicken Pulmonary | 1923 Head Subcutaneous Plexus | 1923 Ductus Venosus | 1925 Venous Development | 1927 Stage 11 Heart | 1928 Heart Blood Flow | 1935 Aorta | 1935 Venous valves | 1938 Pars Membranacea Septi | 1938 Foramen Ovale | 1939 Atrio-Ventricular Valves | 1940 Vena cava inferior | 1940 Early Hematopoiesis | 1941 Blood Formation | 1942 Truncus and Conus Partitioning | Ziegler Heart Models | 1951 Heart Movie | 1954 Week 9 Heart | 1957 Cranial venous system | 1959 Brain Arterial Anastomoses | Historic Embryology Papers | 2012 ECHO Meeting | 2016 Cardiac Review | Historic Disclaimer

Human Development Timecourse

Human heart developmental functional networks[1]

Heart Looping Sequence (SEMs).jpg

  • Cardiogenic region - in splanchnic mesenchyme of prechordal plate region
  • Week 2 pair of thin-walled tubes
  • Week 3 tubes fused, truncus arteriosus outflow, heart contracting
  • Week 4 heart tube continues to elongate, curving to form S shape
  • Week 5 Septation starts, atrial and ventricular
  • Septation continues, atrial septa remains open, foramen ovale
  • Week 40 At birth pressure difference closes foramen ovale leaving a fossa ovalis

Link: Timeline human development

Heart Layers

  • pericardium - covers the heart, formed by 3 layers consisting of a fibrous pericardium and a double layered serous pericardium (parietal layer and visceral epicardium layer).
  • myocardium - muscular wall of the heart, thickest layer formed by spirally arranged cardiac muscle cells.
  • endocardium - lines the heart, epithelial tissue lining the inner surface of heart chambers and valves.

Heart Volume

Week* Heart Volume (ml) Lung Volume (ml)
10 0.6 1.6
18 4.3 10.9
30 26.6 49.3

Table data is "embryonic age" while original reference used gestational age GA (from LMP)[2] Stroke Volume


Week* Left Stroke Volume (ml) Right Stroke Volume (ml) Cardiac Output L/R (ml/min)
10 0.02 0.01 2.39 / 1.8
18 0.32 0.30 43.46 / 46.72
32 2.07 2.67 284.71 / 365.99

Table data is "embryonic age" while original reference used gestational age GA (from LMP) The stroke volume (SV) can be calculated from ultrasound measurement of end diastole volume (EDV) minus end systole volume (ESV); (SV = EDV - ESV).

(Data: Molina FS, Faro C, Sotiriadis A, Dagklis T, Nicolaides KH. Heart stroke volume and cardiac output by four-dimensional ultrasound in normal fetuses. Ultrasound Obstet Gynecol. 2008 Aug;32(2):181-7.

Additional Images

Historic Images

References

  1. <pubmed>20571530</pubmed>| Mol Syst Biol.
  2. <pubmed>16388511</pubmed>

<pubmed>15797462</pubmed> <pubmed>15977172</pubmed> <pubmed>12807866</pubmed> <pubmed>12860885</pubmed> <pubmed>12781678</pubmed> <pubmed>11891982</pubmed> <pubmed>11920381</pubmed> <pubmed>10948449</pubmed>


Terms

  • fibrous trigone - (trigonum fibrosum) term describing the dense connective tissue between the aortic ring and the atrioventricular ring and has a left and right component. The right fibrous trigone (trigonum fibrosum dextrum) lies between the aortic ring and the right atrioventricular ring. The left fibrous trigone (trigonum fibrosum sinistrum) lies between the aortic ring and the left atrioventricular ring.

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.


Glossary Links

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Cite this page: Hill, M.A. (2024, March 28) Embryology Cardiovascular System - Heart Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Heart_Development

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G