Cardiovascular System - Heart Development: Difference between revisions

Revision as of 12:31, 13 October 2014

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Introduction

Human embryo heart (day 54 - 56)

In human embryos the heart begins to beat at about 22-23 days, with blood flow beginning in the 4th week. The heart is therefore one of the earliest differentiating and functioning organs.

The best place for students to start is the Heart Tutorial.

The heart begins very early in mesoderm within the trilaminar embryonic disc. The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.

A key aspect of heart development is the septation of the heart into separate chambers. As the embryonic/fetal circulation is different to the neonatal circulation (lung/pulmonary activation), several defects of heart septation may only become apparent on this transition. One septal "defect" occurs in us all, the foramen ovale (between the 2 atria) which in general closes in the neonate over time.

Embryonic Heart Rate (EHR), early in development the heart starts to spontaneously beat and a recent study by Wisser and Dirschedl in dated human embryos showed an increase up to 63 postmenstrual days or 22 mm greatest length. Thereafter a steady decrease of EHR was noted. Maximal EHR is reached when morphological development of the embryonic heart is completed.

The best place for students to start is the Heart Tutorial.

Basic Heart

Advanced Heart

Historic Embryology - Cardiovascular
1902 Vena cava inferior \| 1905 Brain Blood Vessels \| 1909 Cervical Veins \| 1909 Dorsal aorta and umbilical veins \| 1912 Heart \| 1912 Human Heart \| 1914 Earliest Blood-Vessels \| 1915 Congenital Cardiac Disease \| 1915 Dura Venous Sinuses \| 1916 Blood cell origin \| 1916 Pars Membranacea Septi \| 1919 Lower Limb Arteries \| 1921 Human Brain Vascular \| 1921 Spleen \| 1922 Aortic-Arch System \| 1922 Pig Forelimb Arteries \| 1922 Chicken Pulmonary \| 1923 Head Subcutaneous Plexus \| 1923 Ductus Venosus \| 1925 Venous Development \| 1927 Stage 11 Heart \| 1928 Heart Blood Flow \| 1935 Aorta \| 1935 Venous valves \| 1938 Pars Membranacea Septi \| 1938 Foramen Ovale \| 1939 Atrio-Ventricular Valves \| 1940 Vena cava inferior \| 1940 Early Hematopoiesis \| 1941 Blood Formation \| 1942 Truncus and Conus Partitioning \| Ziegler Heart Models \| 1951 Heart Movie \| 1954 Week 9 Heart \| 1957 Cranial venous system \| 1959 Brain Arterial Anastomoses \| Historic Embryology Papers \| 2012 ECHO Meeting \| 2016 Cardiac Review \| Historic Disclaimer

Textbooks

Citation: UNSW Embryology (13^th ed.) Hill, M.A., 2013. Sydney: UNSW.

Historic Embryology - Cardiovascular
1902 Vena cava inferior \| 1905 Brain Blood Vessels \| 1909 Cervical Veins \| 1909 Dorsal aorta and umbilical veins \| 1912 Heart \| 1912 Human Heart \| 1914 Earliest Blood-Vessels \| 1915 Congenital Cardiac Disease \| 1915 Dura Venous Sinuses \| 1916 Blood cell origin \| 1916 Pars Membranacea Septi \| 1919 Lower Limb Arteries \| 1921 Human Brain Vascular \| 1921 Spleen \| 1922 Aortic-Arch System \| 1922 Pig Forelimb Arteries \| 1922 Chicken Pulmonary \| 1923 Head Subcutaneous Plexus \| 1923 Ductus Venosus \| 1925 Venous Development \| 1927 Stage 11 Heart \| 1928 Heart Blood Flow \| 1935 Aorta \| 1935 Venous valves \| 1938 Pars Membranacea Septi \| 1938 Foramen Ovale \| 1939 Atrio-Ventricular Valves \| 1940 Vena cava inferior \| 1940 Early Hematopoiesis \| 1941 Blood Formation \| 1942 Truncus and Conus Partitioning \| Ziegler Heart Models \| 1951 Heart Movie \| 1954 Week 9 Heart \| 1957 Cranial venous system \| 1959 Brain Arterial Anastomoses \| Historic Embryology Papers \| 2012 ECHO Meeting \| 2016 Cardiac Review \| Historic Disclaimer

Heart Tutorial

Citation: The Developing Human: Clinically Oriented Embryology 9^th ed. Keith L. Moore, T.V.N. Persaud, Mark G. Torchia. Philadelphia, PA: Saunders, 2011. (links available to UNSW students)

Chapter 13 - Cardiovascular System

Citation: Larsen's Human Embryology 4^th ed. Schoenwolf, Gary C; Larsen, William J, (William James). Philadelphia, PA : Elsevier/Churchill Livingstone, c2009. (links available to UNSW students)

Chapter 12 - Development of the Heart

Chapter 13 - Development of the Vasculature

Human Embryology (2nd ed.) Larson Ch7 p151-188 Heart
The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Ch14: p304-349
Before we Are Born (5th ed.) Moore and Persaud Ch12; p241-254
Essentials of Human Embryology Larson Ch7 p97-122 Heart
Human Embryology Fitzgerald and Fitzgerald Ch13-17: p77-111

Links: Embryology Textbooks

Movies

Cardiovascular System Development | Heart Tutorial

‎‎Week 3

@@ Line 1: / Line 1: @@
+{{Header}}
 ==Introduction==
 [[File:Human-heart-E3L.jpg|thumb|300px|Human embryo heart (day 54 - 56)]]In human embryos the heart begins to beat at about 22-23 days, with blood flow beginning in the 4th week. The heart is therefore one of the earliest differentiating and functioning organs.
+The best place for students to start is the [[Cardiac_Embryology|Heart Tutorial]].
 The heart begins very early in mesoderm within the trilaminar embryonic disc. The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.
@@ Line 136: / Line 139: @@
 <nowiki>*</nowiki>  Table data is "embryonic age" while original reference used "gestational age" (from LMP). The stroke volume (SV) can be calculated from ultrasound measurement of end diastole volume (EDV) minus end systole volume (ESV); (SV = EDV - ESV). (Data: [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18634132 Molina FS, Faro C, Sotiriadis A, Dagklis T, Nicolaides KH.] Heart stroke volume and cardiac output by four-dimensional ultrasound in normal fetuses. Ultrasound Obstet Gynecol. 2008 Aug;32(2):181-7.
-==Historic Images==
+==Additional Images==
+===Historic Images===
 <gallery>
 File:Kollmann528.jpg|Fig. 528. Heart of a Rabbit Embryo seen from behind at 3.4 mm head length
@@ Line 154: / Line 159: @@
 <references/>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15797462 Person AD, Klewer SE, Runyan RB.] Cell biology of cardiac cushion development. Int Rev Cytol. 2005;243:287-335. Review.
+<pubmed>15797462</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15977172 Matsui H, Ikeda K, Nakatani K, Sakabe M, Yamagishi T, Nakanishi T, Nakajima Y.] Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin--in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist. Dev Dyn. 2005 Aug;233(4):1419-29.
+<pubmed>15977172</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12807866 Moorman A, Webb S, Brown NA, Lamers W, Anderson RH.] Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart. 2003 Jul;89(7):806-14.
+<pubmed>12807866</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12860885 Anderson RH, Webb S, Brown NA, Lamers W, Moorman A.] Development of the heart: (2) Septation of the atriums and ventricles. Heart. 2003 Aug;89(8):949-58.
+<pubmed>12860885</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12781678 Brand T.] Heart development: molecular insights into cardiac specification and early morphogenesis. Dev Biol. 2003 Jun 1;258(1):1-19.
+<pubmed>12781678</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11891982 Yutzey KE, Kirby ML.] Wherefore heart thou? Embryonic origins of cardiogenic mesoderm. Dev Dyn. 2002 Mar;223(3):307-20.
+<pubmed>11891982</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11920381 Eisenberg LM.] Belief vs. scientific observation: the curious story of the precardiac mesoderm. Anat Rec. 2002 Apr 1;266(4):194-7.
+<pubmed>11920381</pubmed>
-* [http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10948449 Davidson AJ, Zon LI.] Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis. Curr Top Dev Biol. 2000;50:45-60.
+<pubmed>10948449</pubmed>
@@ Line 174: / Line 179: @@
-{{Template:Glossary|Template:Glossary}}
-{{Template:Footer|Template:Footer}}
+{{Glossary}}
+{{Footer}}
 [[Category:Cardiovascular]] [[Category:Heart]]

Week*	Heart Volume (ml)	Lung Volume (ml)
10	0.6	1.6
18	4.3	10.9
30	26.6	49.3

Week*	Left Stroke Volume (ml)	Right Stroke Volume (ml)	Cardiac Output L/R (ml/min)
10	0.02	0.01	2.39 / 1.8
18	0.32	0.30	43.46 / 46.72
32	2.07	2.67	284.71 / 365.99

Cardiovascular System - Heart Development: Difference between revisions

Revision as of 12:31, 13 October 2014

Introduction

Basic Heart

Advanced Heart

Textbooks

Movies

Human Development Timecourse

Heart Layers

Heart Volume

Additional Images

Historic Images

References

Terms

External Links

Glossary Links