Cardiovascular System - Coronary Circulation Development: Difference between revisions
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* '''Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling'''<ref name="PMID18093989"><pubmed>18093989</pubmed></ref> "In vitro, human arterial coronary endothelial cells were treated with VEGF121 or VEGF165 upon which RT-qPCR was performed. In vivo, mutant coronary arterial endothelium showed a decrease in protein expression of arterial markers such as cleaved Notch1, Delta-like4, and ephrinB2 concomitant with an increase of venous markers such as chicken ovalbumin upstream promoter transcription factor II. The venous endothelium showed the opposite effect, which was confirmed on the mRNA level." | * '''Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling'''<ref name="PMID18093989"><pubmed>18093989</pubmed></ref> "In vitro, human arterial coronary endothelial cells were treated with VEGF121 or VEGF165 upon which RT-qPCR was performed. In vivo, mutant coronary arterial endothelium showed a decrease in protein expression of arterial markers such as cleaved Notch1, Delta-like4, and ephrinB2 concomitant with an increase of venous markers such as chicken ovalbumin upstream promoter transcription factor II. The venous endothelium showed the opposite effect, which was confirmed on the mRNA level." | ||
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(More? [[Talk:Cardiovascular_System_-_Coronary_Circulation_Development|recent references]]) | |||
==Mouse Coronary Vessel Development== | ==Mouse Coronary Vessel Development== |
Revision as of 11:12, 16 October 2010
Introduction
The coronary circulation provides the blood supply to the heart required for the normal muscular function. From recent mouse studies, the origin of this specialised vasculature is from the sinus venosus.
Development of the heart and vascular system begins very early in mesoderm both within (embryonic) and outside (extra embryonic) the embryo. Vascular development therefore occurs in many places, the most obvious though is the inflow and outflow in the forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo.
The coronary circulation an important medical topic postnatally. Blockage and failure of this system leads initially to angina, continued ischemia leads to hypoxic death of cardiac muscle and myocardial infarction, a heart attack.
For general information about blood vessel development, see Blood Vessel Development and note that blood vessels also occurs outside the embryo in the extra-embryonic mesoderm of the yolk sac (vitelline) and in the villi of the placenta.
Some Recent Findings
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(More? recent references)
Mouse Coronary Vessel Development
Image showing changes in venous (blue) and arterial (red) marker expression during coronary development; black indicates dedifferentiated venous cells.[1]
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See also Category:Heart ILP and Category:Heart
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Cite this page: Hill, M.A. (2024, March 28) Embryology Cardiovascular System - Coronary Circulation Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiovascular_System_-_Coronary_Circulation_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G