https://embryology.med.unsw.edu.au/embryology/index.php?title=Cardiac_Muscle_Histology&feed=atom&action=history
Cardiac Muscle Histology - Revision history
2024-03-28T20:42:44Z
Revision history for this page on the wiki
MediaWiki 1.39.6
https://embryology.med.unsw.edu.au/embryology/index.php?title=Cardiac_Muscle_Histology&diff=141021&oldid=prev
Z8600021: Redirected page to Cardiovascular System - Heart Histology
2014-08-13T04:43:27Z
<p>Redirected page to <a href="/embryology/index.php?title=Cardiovascular_System_-_Heart_Histology" title="Cardiovascular System - Heart Histology">Cardiovascular System - Heart Histology</a></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en-GB">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:43, 13 August 2014</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#REDIRECT Cardiovascular System - Heart Histology</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#REDIRECT <ins style="font-weight: bold; text-decoration: none;">[[</ins>Cardiovascular System - Heart Histology<ins style="font-weight: bold; text-decoration: none;">]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Introduction==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Introduction==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>
Z8600021
https://embryology.med.unsw.edu.au/embryology/index.php?title=Cardiac_Muscle_Histology&diff=141020&oldid=prev
Z8600021 at 04:42, 13 August 2014
2014-08-13T04:42:23Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en-GB">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:42, 13 August 2014</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">#REDIRECT Cardiovascular System - Heart Histology</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Introduction==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Introduction==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>
Z8600021
https://embryology.med.unsw.edu.au/embryology/index.php?title=Cardiac_Muscle_Histology&diff=114442&oldid=prev
Z8600021: /* Introduction */
2013-02-16T02:15:38Z
<p><span dir="auto"><span class="autocomment">Introduction</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en-GB">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:15, 16 February 2013</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10">Line 10:</td>
<td colspan="2" class="diff-lineno">Line 10:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">:'''</del>Muscle Histology<del style="font-weight: bold; text-decoration: none;">:''' [[Skeletal Muscle Histology|Skeletal Muscle]] | [[Cardiac Muscle Histology|Cardiac Muscle]] | [[Smooth Muscle Histology|Smooth Muscle]]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{</ins>Muscle Histology <ins style="font-weight: bold; text-decoration: none;">links}}</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Histology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Histology==</div></td></tr>
</table>
Z8600021
https://embryology.med.unsw.edu.au/embryology/index.php?title=Cardiac_Muscle_Histology&diff=114440&oldid=prev
Z8600021 at 02:14, 16 February 2013
2013-02-16T02:14:09Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en-GB">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:14, 16 February 2013</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td>
<td colspan="2" class="diff-lineno">Line 8:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>** Intercalated discs invariably occur at the ends of cardiac muscle cells in a region corresponding to the Z-line of the myofibrils.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>** Intercalated discs invariably occur at the ends of cardiac muscle cells in a region corresponding to the Z-line of the myofibrils.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Cardiac muscle does not contain cells equivalent to the satellite cells of skeletal muscle.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Cardiac muscle does not contain cells equivalent to the satellite cells of skeletal muscle.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:'''Muscle Histology:''' [[Skeletal Muscle Histology|Skeletal Muscle]] | [[Cardiac Muscle Histology|Cardiac Muscle]] | [[Smooth Muscle Histology|Smooth Muscle]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Histology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Histology==</div></td></tr>
</table>
Z8600021
https://embryology.med.unsw.edu.au/embryology/index.php?title=Cardiac_Muscle_Histology&diff=114438&oldid=prev
Z8600021: Created page with "==Introduction== Cardiac muscle, the myocardium, consists of cross-striated muscle cells, cardiomyocytes, with one centrally placed nucleus. * Nuclei are oval, rather pale an..."
2013-02-16T02:13:02Z
<p>Created page with "==Introduction== Cardiac muscle, the myocardium, consists of cross-striated muscle cells, cardiomyocytes, with one centrally placed nucleus. * Nuclei are oval, rather pale an..."</p>
<p><b>New page</b></p><div>==Introduction==<br />
<br />
Cardiac muscle, the myocardium, consists of cross-striated muscle cells, cardiomyocytes, with one centrally placed nucleus.<br />
* Nuclei are oval, rather pale and located centrally in the muscle cell which is 10 - 15 µm wide.<br />
* Cardiac muscle cells excitation is mediated by rythmically active modified cardiac muscle cells.<br />
* Cardiac muscle is innervated by the autonomic nervous system (involuntary), which adjusts the force generated by the muscle cells and the frequency of the heart beat.<br />
* Cardiac muscle cells often branch at acute angles and are connected to each other by specialisations of the cell membrane in the region of the '''intercalated discs'''. <br />
** Intercalated discs invariably occur at the ends of cardiac muscle cells in a region corresponding to the Z-line of the myofibrils.<br />
* Cardiac muscle does not contain cells equivalent to the satellite cells of skeletal muscle.<br />
<br />
==Histology==<br />
<br />
{|<br />
| [[File:Cardiac_muscle_histology.jpg]]<br />
<br />
Cardiac muscle histology<br />
| Image of primate heart stained with Alizarin blue.<br />
<br />
* Red Blood Cells (orange cells) Cardiac Muscle Cells (blue)<br />
* Cardiac muscle cells are cut longitudinally. <br />
* At high magnification see both striations and the large nuclei of the cardiac muscle cells.<br />
* Follow the course of individual cardiac muscle cells and note fine, dark blue lines which seem to cross (traverse) the fibres. <br />
* '''Intercalated Discs''' that connect the individual muscle cells and permit the conduction of electrical impulses between the cells.<br />
** seen in longitudinal sections.<br />
<br />
|}<br />
<br />
[[File:Heart_histology_002.jpg]] [[File:Heart_histology_004.jpg]]<br />
<br />
[[File:Heart_histology_003.jpg]] [[File:Heart_histology_001.jpg]]<br />
<br />
===Unlabeled Images===<br />
<gallery><br />
File:Heart_histology_101.jpg<br />
File:Heart_histology_102.jpg<br />
File:Heart_histology_103.jpg<br />
File:Heart_histology_104.jpg<br />
File:Heart_histology_105.jpg<br />
File:Heart_histology_106.jpg<br />
File:Heart_histology_107.jpg<br />
</gallery><br />
<br />
==Cardiac Layers==<br />
<br />
===Endocardium=== <br />
* Inner layer of the heart, contains blood vessels. Has 3 sublayers<br />
** Endothelium - innermost portion a simple squamous epithelium.<br />
** Smooth Muscle and Connective Tissue - middle layer of the endocardium is mix of connective tissue and smooth muscle.<br />
** Subendocardial Layer - outer layer of the endocardium is loose connective tissue joining the endocardium and myocardium.<br />
<br />
===Myocardium===<br />
* Middle layer of the heart, thickest contains cardiomyocytes, blood vessels.<br />
* Muscular layer.<br />
<br />
===Epicardium===<br />
* Outer layer of the heart, contains blood vessels and lymphatics.<br />
* Visceral layer of pericardium rather thin.<br />
<br />
==Cardiac Features==<br />
[[File:Cardiac muscle EM02.jpg|thumb|Cardiac muscle (electron micrograph)]]<br />
[[File:Cardiac muscle EM01.jpg|thumb|Cardiac muscle (electron micrograph)]]<br />
===Intercalated Discs===<br />
* seen in longitudinal sections.<br />
* connect the individual muscle cells.<br />
* permit the conduction of electrical impulses between the cells.<br />
<br />
Histology "step-like" appearance due to:<br />
* transverse part - crossing fibres at right angle to myofibrils.<br />
* lateral part - runs in parallel to myofibrils.<br />
<br />
Junctional Components<br />
# '''Fascia adherens''' – major portion of transverse component. Anchoring sites for actin, and connect to the closest sarcomere.<br />
# '''Macula adherens''' – (desmosomes) transverse and lateral components. Bind individual myocytes to one another. stop separation during contraction by binding intermediate filaments, joining the cells together. Macula adherens junctions are also called desmosomes.<br />
# '''Gap junctions''' - lateral component. Allow action potentials to spread between cardiac cells by passage of ions between cells, producing depolarization of the heart muscle. Allows muscle to act as syncytium.<br />
<br />
<br />
:'''Links:''' [http://cardiovascres.oxfordjournals.org/content/80/1/9/F3.expansion.html EM image - intercalated disc]<br />
<br />
===Purkinje Fibres===<br />
[[File:Heart_histology_001.jpg|thumb|Purkinje Fibres]]<br />
* modified cardiac muscle cells. Compared to ordinary cardiac muscle cells:<br />
** contain large amounts of glycogen.<br />
** fewer myofibrils.<br />
** thicker cells.<br />
* extend from the '''atrioventricular node''', pierces the fibrous body, divides into left and right bundles, and travels, beneath the endocardium, towards the apex of the heart.<br />
* bundle branches contact cardiac muscle cells through specialisations similar to intercalated discs. <br />
* conduct stimuli faster than ordinary cardiac muscle cells (2-3 m/s vs. 0.6 m/s).<br />
* discovered in 1839 by Jan Evangelista Purkyně).<br />
<br />
<br />
{{Heart Histology}}<br />
<br />
==Terms==<br />
* '''cardiomyocyte''' - <br />
* '''chordae tendineae''' - tricuspid and mitral valves connective tissue bands attached on the other end to the papillary muscles.<br />
* '''intercalated disc''' -<br />
* '''nodule''' - (of semilunar valve) small fibrous nodules located in the middle of the flaps, the nodules of the semilunar valve come closely together to fill the triangular opening. <br />
* '''Purkinje fibres''' - <br />
<br />
{{Glossary}}<br />
<br />
{{Footer}}<br />
<br />
<br />
[[Category:Cardiovascular]] [[Category:Histology]] [[Category:Heart]]</div>
Z8600021