Book - Liver development: Difference between revisions
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hepatogenesis have been identified. Recently application of this knowledge has enabled researchers to produce “hepatic-like” tissue from embryonic stem (ES) cells in vitro, which may ultimately lead to therapeutically useful tissue for transplantation. This review summarizes the current understanding of the molecular pathways controlling liver and biliary system development focusing on studies in the mouse embryo where this process is best understood. | hepatogenesis have been identified. Recently application of this knowledge has enabled researchers to produce “hepatic-like” tissue from embryonic stem (ES) cells in vitro, which may ultimately lead to therapeutically useful tissue for transplantation. This review summarizes the current understanding of the molecular pathways controlling liver and biliary system development focusing on studies in the mouse embryo where this process is best understood. | ||
[[Media:Bookshelf NBK27068.pdf|Liver Development (2008) PDF]] | |||
==Reference== | |||
{{Ref-Zorn2008}} | {{Ref-Zorn2008}} | ||
Zorn, A.M., Liver development (October 31, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.25.1, http://www.stembook.org. | Zorn, A.M., Liver development (October 31, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.25.1, http://www.stembook.org. | ||
===Copyright=== | |||
2008 Aaron M. Zorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | 2008 Aaron M. Zorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||
{{Footer}} | {{Footer}} | ||
[[Category:Liver]] | [[Category:Liver]] |
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Zorn AM. (2008). Liver development. , , . PMID: 20614624 DOI. | online extract | PDF
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This 2008 online book chapter by Zorn describes the development of the liver. |
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Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History | Historic Embryology Papers) |
Liver Development
Aaron M. Zorn, Division of Developmental Biology, Cincinnati Children’s Research Foundation, Cincinnati, Ohio 45229-3039, USA
Abstract
The liver is the largest internal organ and it provides many essential metabolic, exocrine and endocrine functions. Hepatocytes are the principal cell type in the liver and these along with biliary epithelial cells are derived from the embryonic endoderm. Embryological experiments in animal models have demonstrated that liver development occurs through a progressive series of reciprocal tissue interactions between the embryonic endoderm and nearby mesoderm. In the last ten years many of the genes and molecular pathways that regulate hepatogenesis have been identified. Recently application of this knowledge has enabled researchers to produce “hepatic-like” tissue from embryonic stem (ES) cells in vitro, which may ultimately lead to therapeutically useful tissue for transplantation. This review summarizes the current understanding of the molecular pathways controlling liver and biliary system development focusing on studies in the mouse embryo where this process is best understood.
Reference
Zorn AM. (2008). Liver development. , , . PMID: 20614624 DOI. | online extract | PDF
Zorn, A.M., Liver development (October 31, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.25.1, http://www.stembook.org.
Copyright
2008 Aaron M. Zorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this page: Hill, M.A. (2024, April 25) Embryology Book - Liver development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Book_-_Liver_development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G