Introduction
- (large gestational age, LGA) Term used to describe a newborn with an excessive birth weight. The definition is either a birth weight of 4000 to 4500 g (8 lb 13 oz to 9 lb 15 oz) or greater than 90% for gestational age after correcting for neonatal sex and ethnicity. There are a range of overgrowth syndromes associated with developmental delay, tumors, and other anomalies with genetic causes and syndromes (Pallister-Killian, Beckwith-Wiedemann, Sotos, Perlman, and Simpson-Golabi-Behmel) rarely diagnosed prenatally.
| Maternal Diabetes
Some Recent Findings
- Genetic considerations in the prenatal diagnosis of overgrowth syndromes[1] "Large (>90%) for gestational age (LGA) fetuses are usually identified incidentally. Detection of the LGA fetus should first prompt the provider to rule out incorrect dates and maternal diabetes. Once this is done, consideration should be given to certain overgrowth syndromes, especially if anomalies are present. The overgrowth syndromes have significant clinical and molecular overlap, and are associated with developmental delay, tumors, and other anomalies. Although genetic causes of overgrowth are considered postnatally, they are infrequently diagnosed prenatally. Here, we review prenatal sonographic findings in fetal overgrowth syndromes, including Pallister-Killian, Beckwith-Wiedemann, Sotos, Perlman, and Simpson-Golabi-Behmel. We also discuss prenatal diagnosis options and recurrence risks."
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References
- ↑ <pubmed>19609940</pubmed>
Reviews
Articles
<pubmed>20543995</pubmed>
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