BGDB Sexual Differentiation - Early Embryo: Difference between revisions
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* This looped animation shows the 3 stages of kidney development (pink) in relation to the hindgut region between Week 4 and 5. | * This looped animation shows the 3 stages of kidney development (pink) in relation to the hindgut region between Week 4 and 5. | ||
* The earliest stage of kidney development begins up near the pharyngeal arches as the '''pronephros''' (cervical nephrotomes) which quickly degenerate, beside these the mesonephric duct begins to form (purple). | * The earliest stage of kidney development begins up near the pharyngeal arches as the '''pronephros''' (cervical nephrotomes) which quickly degenerate, beside these the mesonephric duct begins to form (purple). | ||
* The next stage is the extensive mesonephros (red) which extends down towards the developing hindgut region (yellow). Associated with the mesonephros is the mesonephric duct. | * The next stage is the extensive mesonephros (red) which extends down towards the developing hindgut region (yellow). Associated with the mesonephros is the '''mesonephric duct'''. | ||
* The final stage in | * The mesonephric duct gives off a lateral branch forming the '''ureteric bud'''. | ||
* The ureteric bud interacts with the surrounding mesenchyme to begin the final stage in renal development, formation of the metanephros (pink) which will form the adult kidney. | |||
Revision as of 15:02, 2 June 2011
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
Week 4 to 5
<wikiflv width="560" height="588" autoplay="true" position="left">Stage13_GITlarge.flv|File:Stage13-GIT-icon.jpg</wikiflv> |
Begin by observing the internal structure of the embryo at the end of week 4 and the beginning of week 5.
Colour code:
|
Mesonephros and Mesonephric Duct
E1-G4: Section passes dorsally to the mesonephros. Return to G4 and then follow the caudal route of the mesonephric duct into the sacral region.
E1L | E2L | E3L | E4L | E5L | E6L | E7L |
F1L | F2L | F3L | F4L | F5L | F6L | F7L |
G1L | G2L | G3L | G4L |
Kidney and Mesonephric Duct
<wikiflv width="356" height="500" autoplay="true" position="left">Urogenital_sinus_001.flv|File:Urogenital_sinus_001 icon.jpg</wikiflv> |
Now go back and observe the development of the intermediate mesoderm.
|
Primitive Urogenital Sinus
Gonad Development
Male Testis
Female Ovary
Gonadal Development Comparison
Now directly compare the development of the male and female gonad (click image to start, these may not be synchronised).
Gonad-icon.jpg</wikiflv> | Gonad-icon.jpg</wikiflv> |
Ovary | Testis |
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
Additional Information
The following figures are from a recent review of Sex determination and gonadal development in mammals.[1]
- Signaling in genital development
- Sex reversal in humans caused by abnormal X-Y exchange
- Mesonephric tubules in the 11.5 dpc mouse urogenital ridge
- Development and differentiation of the genital duct system
- The migratory pathway of primordial germ cells
- Structure of the early fetal testis
- Differentiation of pre-Sertoli cells into Sertoli cells
- Model for cell-autonomous and prostaglandin-mediated upregulation of Sox9 in pre-Sertoli cells
- Visualization of testicular cell types
- Ovary and follicle development and differentiation
- Postulated molecular pathway leading to the formation of the bipotential genital ridge
- Structure of mouse and human SRY protein
- Postulated interaction of molecular players involved in early testicular development
References
- ↑ <pubmed>17237341</pubmed>| Physiol. Rev.
Nussey S, Whitehead S. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001. Chapter 6 The gonad
BGDB: Lecture - Gastrointestinal System | Practical - Gastrointestinal System | Lecture - Face and Ear | Practical - Face and Ear | Lecture - Endocrine | Lecture - Sexual Differentiation | Practical - Sexual Differentiation | Tutorial
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Cite this page: Hill, M.A. (2024, April 25) Embryology BGDB Sexual Differentiation - Early Embryo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDB_Sexual_Differentiation_-_Early_Embryo
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G