BGDB Sexual Differentiation - Early Embryo: Difference between revisions
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==Additional Information== | ==Additional Information== | ||
{{Med Prac additional Information}} | {{Med Prac additional Information}} | ||
Male pathway | |||
* initially Sry, Sox9 and Fgf9 are up-regulated. | |||
* then FGF9, PDGF and DHH drive structural and functional changes. | |||
Female pathway | |||
* during sex determination period RSPO1 (R-spondin-1) a secreted protein interacts with WNT4. | |||
===References=== | ===References=== |
Revision as of 22:44, 1 June 2014
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
Week 4 to 5
<mediaplayer width='550' height='580' image="http://php.med.unsw.edu.au/embryology/images/4/46/Stage13-GIT-icon.jpg">File:Stage13 GIT3d.mp4</mediaplayer> | Begin by observing the internal structure of the embryo at the end of week 4 and the beginning of week 5.
Colour code:
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Mesonephros and Mesonephric Duct
Section 29-46: (E1-G4) Section passes dorsally to the mesonephros. Return to G4 and then follow the caudal route of the mesonephric duct into the sacral region.
29 (E1L) | 30 (E2L) | 31 (E3L) | 32 (E4L) | 33 (E5L) | 34 (E6L) | 35 (E7L) |
36 (F1L) | 37 (F2L) | 38 (F3L) | 39 (F4L) | 40 (F5L) | 41 (F6L) | 42 (F7L) |
43 (G1L) | 44 (G2L) | 45 (G3L) | 46 (G4L) |
Kidney and Mesonephric Duct
<mediaplayer width='360' height='500' image="http://php.med.unsw.edu.au/embryology/images/f/fe/Urogenital_sinus_001_icon.jpg">File:Urogenital_sinus_001.mp4</mediaplayer> | Now go back and observe the development of the intermediate mesoderm.
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Primitive Urogenital Sinus
<mediaplayer width='420' height='415' image="http://php.med.unsw.edu.au/embryology/images/8/88/Urogenital_septum_001_icon.jpg">File:Urogenital_septum_001.mp4</mediaplayer> | Stages in septation of the urogenital sinus between Week 4 and 6.
Several different defects in both sexes can occur if this septation process is not correctly aligned (rectourethral fistula, rectovaginal fistula). Cloacal Membrane (intact) (week 4 Carnegie stage 12) |
Gonad Development
Male Testis
<mediaplayer width='350' height='650' image="http://php.med.unsw.edu.au/embryology/images/f/fa/Gonad-icon.jpg">File:Testis 001.mp4</mediaplayer> |
Development of the male gonad showing medullary sex cords
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Female Ovary
<mediaplayer width='350' height='650' image="http://php.med.unsw.edu.au/embryology/images/f/fa/Gonad-icon.jpg">File:Ovary_001.mp4</mediaplayer> |
Development of the female gonad showing medullary sex cords
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Gonadal Development Comparison
Now directly compare the development of the male and female gonad (click image to start, these may not be synchronised).
Ovary | Testis |
---|---|
<mediaplayer width='350' height='650' image="http://php.med.unsw.edu.au/embryology/images/f/fa/Gonad-icon.jpg">File:Ovary_001.mp4</mediaplayer> | <mediaplayer width='350' height='650' image="http://php.med.unsw.edu.au/embryology/images/f/fa/Gonad-icon.jpg">File:Testis 001.mp4</mediaplayer> |
Ovary Development Movie | Testis Development Movie |
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio |
Additional Information
Additional Information - Content shown under this heading is not part of the material covered in this class. It is provided for those students who would like to know about some concepts or current research in topics related to the current class page. |
Male pathway
- initially Sry, Sox9 and Fgf9 are up-regulated.
- then FGF9, PDGF and DHH drive structural and functional changes.
Female pathway
- during sex determination period RSPO1 (R-spondin-1) a secreted protein interacts with WNT4.
References
<pubmed>17237341</pubmed>| Physiol. Rev.
Nussey S, Whitehead S. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001. Chapter 6 The gonad
History
BGDB: Lecture - Gastrointestinal System | Practical - Gastrointestinal System | Lecture - Face and Ear | Practical - Face and Ear | Lecture - Endocrine | Lecture - Sexual Differentiation | Practical - Sexual Differentiation | Tutorial
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Cite this page: Hill, M.A. (2024, April 24) Embryology BGDB Sexual Differentiation - Early Embryo. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDB_Sexual_Differentiation_-_Early_Embryo
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G