BGDB Practical - Sexual Differentiation: Difference between revisions

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{{BGDB SexDiffn}}
{{BGDB SexDiffn}}
This practical will introduce the topic of sexual differentiation during development through a series of online resource pages.
This practical will introduce the topic of sexual differentiation during development through a series of online resource pages.


'''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation.
'''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation.


'''Key Concepts:''' Primordial germ cells, gonad, internal genitalia, external genitalia, ovary, testes, puberty, hormonal changes, gametogenesis, abnormalities.
 
'''Key Concepts:''' {{primordial germ cell}}, sex chromosomes, gonad, internal genitalia, external genitalia, {{ovary}}, {{testis}}, {{puberty}}, hormonal changes, gametogenesis, {{genital abnormalities}} ({{DSD}}).
 


==Background==
==Background==
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==Genital Timeline==
==Questions==
I am testing a new way of student submitting questions live during practical class, particularly for Port Macquarie students.
{|
| [[File:Sli.do-icon.png|link=https://www.sli.do]]
|
# Go to [https://www.sli.do SLI.DO]
# Enter event code '''#N004'''
# Post your question.


24 days - intermediate mesoderm, pronephros primordium
<br><br>
You do not need to log-in or create an account. I will monitor at this page during class and provide feedback.
|}


28 days - mesonephros and mesonephric duct
==Genital Timeline==
''These are approximate timings and stages only.''


35 days - uteric bud, metanephros, urogenital ridge
* [[Carnegie stage 11|24 days]] - intermediate mesoderm, pronephros primordium
* [[Carnegie stage 13|28 days]] - mesonephros and mesonephric duct
* [[Carnegie stage 15|35 days]] - uteric bud, metanephros, urogenital ridge
* [[Carnegie stage 17|42 days]] - cloacal divison, gonadal primordium (indifferent)
* [[Carnegie stage 19|49 days]] - paramesonephric duct, gonadal differentiation
* [[Carnegie stage 23|56 days]] - paramesonephric duct fusion (female)
* 100 days - primary follicles (ovary)
* postnatal 2 months of age - male primordial germ cells (gonocytes) are replaced by adult dark (Ad) and pale (Ap) spermatogonia forming the spermatogonial stem cell (SSC) population.


42 days - cloacal divison, gonadal primordium (indifferent)
==Textbooks==


49 days - paramesonephric duct, gonadal differentiation
{|
! Textbooks
|-
| [[File:Logo.png|alt=Embryo logo|80px]]
| {{Embryo citation}}
{{Genital Links}}
|-
| [[File:The Developing Human, 10th edn.jpg|90px]]
| {{MPT2015APAcitation}} (links only function with UNSW connection)


56 days - paramesonephric duct fusion (female)
Chapter 12 [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074364&pg=329 Urogenital System]
|-
| [[File:Larsen's human embryology 5th ed.jpg|90px]]
| {{Larsen2015APAcitation}}(links only function with UNSW connection)


100 days - primary follicles (ovary)


==Textbooks==
Chapter 15 [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074524&pg=393 Development of the Urinary System]
{|
| [[File:The Developing Human, 8th edn.jpg|80px]]
| Moore, K.L. &amp; Persuad, T.V.N. (2008). <i>The Developing Human: clinically oriented embryology</i> (8<sup>th</sup> ed.). Philadelphia: Saunders.


The following chapter links only work with a UNSW connection and can also be accessed through this  [http://searchfirst.library.unsw.edu.au/primo_library/libweb/action/search.do?vid=UNSW&amp;fn=search&amp;vl(freeText0)=UNSW_SFX14190000000048007 UNSW Library connection].
Chapter 16 [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074524&pg=412 Development of the Reproductive System]
* [http://www.mdconsult.com/books/linkTo?type=bookPage&amp;isbn=978-1-4160-3706-4&amp;eid=4-u1.0-B978-1-4160-3706-4..50015-3 Chapter 12 - The Urogenital System]
|-
|-
| [[File:Larsen's human embryology 4th edn.jpg|80px]]
| [[File:Endocrinology - An Integrated Approach.png|80px]]
| Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H. (2009). <i>Larsen’s Human Embryology</i> (4<sup>th</sup> ed.). New York; Edinburgh: Churchill Livingstone.
| Nussey, S and Saffron Whitehead, S. <i>Endocrinology: An Integrated Approach</i>. Oxford: BIOS Scientific Publishers; 2001.
 
Chapter 6 [http://www.ncbi.nlm.nih.gov/books/NBK29 The gonad]


The following chapter links only work with a UNSW connection and can also be accessed through this [http://searchfirst.library.unsw.edu.au/primo_library/libweb/action/search.do?vid=UNSW&fn=search&vl(freeText0)=UNSW_SFX14190000000047996 UNSW Library connection].
* [http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06811-9&eid=4-u1.0-B978-0-443-06811-9..10015-6 Chapter 15 - Development of the Urogenital System]
|-
| [[File:Logo.png|80px]]
| Hill, M.A. (2011) <i>UNSW Embryology</i> (11<sup>th</sup> ed.). Sydney:UNSW.
* [[BGD_Lecture_-_Sexual_Differentiation|BGDB Lecture 2011]]
* [[Media:BGDB PracManual 2011 Practical 11.pdf|BGDB Practical Manual 2011 Practical 11]]
* {{Template:Genital Links}}
|}
|}


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{{Template:BGDBFooter}}
{{BGDBFooter}}

Revision as of 20:15, 4 June 2018

Introduction

BGDsmall.jpg
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio


This practical will introduce the topic of sexual differentiation during development through a series of online resource pages.


Aim: This practical is an introduction to the earliest events in Sexual Differentiation.


Key Concepts: primordial germ cell, sex chromosomes, gonad, internal genitalia, external genitalia, ovary, testis, puberty, hormonal changes, gametogenesis, genital abnormalities (DSD).


Background

Historic-testis.jpg

Historic-ovary.jpg

Historic Gonad Images

Two key systems, neural and reproductive, develop over an extended period from the early embryo to puberty and the emerging adult. The genital system is closely linked developmentally to the urinary system, often called the urogenital system. This practical will therefore cover early development of both system.

In understanding embryonic sexual development, think of a cascade of sequence dependent events that transform indifferent gonads, internal and external genitalia into distinct male and female structures.

The process begins with gonad differentiation, which itself is tied developmentally back at the initial event of fertilization and the presence of either a Y or X chromosome in the sperm.

The endpoint of development could be considered the post-puberty active reproductive system. Interestingly, recent research is pointing to a link between neural and reproductive systems in how male and female brains may differentially develop under the influence of sex hormones and perhaps even the sex chromosomes.


  • There are 6 pages to work through in today's practical class, listed beside the small BGD icon at the top and bottom of each page.
  • Additional information sections are not part of the practical class content.

Questions

I am testing a new way of student submitting questions live during practical class, particularly for Port Macquarie students.

Sli.do-icon.png
  1. Go to SLI.DO
  2. Enter event code #N004
  3. Post your question.



You do not need to log-in or create an account. I will monitor at this page during class and provide feedback.

Genital Timeline

These are approximate timings and stages only.

  • 24 days - intermediate mesoderm, pronephros primordium
  • 28 days - mesonephros and mesonephric duct
  • 35 days - uteric bud, metanephros, urogenital ridge
  • 42 days - cloacal divison, gonadal primordium (indifferent)
  • 49 days - paramesonephric duct, gonadal differentiation
  • 56 days - paramesonephric duct fusion (female)
  • 100 days - primary follicles (ovary)
  • postnatal 2 months of age - male primordial germ cells (gonocytes) are replaced by adult dark (Ad) and pale (Ap) spermatogonia forming the spermatogonial stem cell (SSC) population.

Textbooks

Textbooks
Embryo logo Hill, M.A. (2020). UNSW Embryology (20th ed.) Retrieved March 29, 2024, from https://embryology.med.unsw.edu.au
Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | endocrine gonad‎ | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
Female | X | X inactivation | ovary | corpus luteum | oocyte | uterus | vagina | reproductive cycles | menstrual cycle | Category:Female
Male | Y | SRY | testis | spermatozoa | ductus deferens | penis | prostate | Category:Male
Historic Embryology - Genital 
General: 1901 Urinogenital Tract | 1902 The Uro-Genital System | 1904 Ovary and Testis | 1912 Urinogenital Organ Development | 1914 External Genitalia | 1921 Urogenital Development | 1921 External Genital | 1942 Sex Cords | 1953 Germ Cells | Historic Embryology Papers | Historic Disclaimer
Female: 1904 Ovary and Testis | 1904 Hymen | 1912 Urinogenital Organ Development | 1914 External Genitalia | 1914 Female | 1921 External Genital | 1927 Female Foetus 15 cm | 1927 Vagina | 1932 Postnatal Ovary
Male: 1887-88 Testis | 1904 Ovary and Testis | 1904 Leydig Cells | 1906 Testis vascular | 1909 Prostate | 1912 Prostate | 1914 External Genitalia | 1915 Cowper’s and Bartholin’s Glands | 1920 Wolffian tubules | 1935 Prepuce | 1935 Wolffian Duct | 1942 Sex Cords | 1943 Testes Descent | Historic Embryology Papers | Historic Disclaimer
The Developing Human, 10th edn.jpg Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2015). The developing human: clinically oriented embryology (10th ed.). Philadelphia: Saunders. (links only function with UNSW connection)

Chapter 12 Urogenital System

Larsen's human embryology 5th ed.jpg Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone.(links only function with UNSW connection)


Chapter 15 Development of the Urinary System

Chapter 16 Development of the Reproductive System

Endocrinology - An Integrated Approach.png Nussey, S and Saffron Whitehead, S. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001.

Chapter 6 The gonad


BGDsmall.jpg
Practical 12: Sex Determination | Early Embryo | Late Embryo | Fetal | Postnatal | Abnormalities | 2011 Audio




BGDsmall.jpg

BGDB: Lecture - Gastrointestinal System | Practical - Gastrointestinal System | Lecture - Face and Ear | Practical - Face and Ear | Lecture - Endocrine | Lecture - Sexual Differentiation | Practical - Sexual Differentiation | Tutorial


Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link



Cite this page: Hill, M.A. (2024, March 29) Embryology BGDB Practical - Sexual Differentiation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/BGDB_Practical_-_Sexual_Differentiation

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G