Adipose Tissue Development: Difference between revisions
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* '''The fat controller: adipocyte development'''<ref name=PMID23209380><pubmed>23209380</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507952 PMC3507952] | [http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001436 PLoS Biol.]</ref> "Obesity is a condition characterized by excess adipose tissue that results from positive energy balance and is the most common metabolic disorder in the industrialized world. ... Adipocytes are not created from other adipocytes, but they arise from precursor cells. In the last two decades, scientists have discovered the function of many proteins that influence the ability of precursor cells to become adipocytes. If the expansion of the adipose tissue is the problem, it seems logical that adipocyte development inhibitors could be a viable anti-obesity therapeutic. However, factors that block adipocyte development and limit adipocyte expansion also impair metabolic health. This notion may be counterintuitive, but several lines of evidence support the idea that blocking adipocyte development is unhealthy. For this reason it is clear that we need a better understanding of adipocyte development." | * '''The fat controller: adipocyte development'''<ref name=PMID23209380><pubmed>23209380</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507952 PMC3507952] | [http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001436 PLoS Biol.]</ref> "Obesity is a condition characterized by excess adipose tissue that results from positive energy balance and is the most common metabolic disorder in the industrialized world. ... Adipocytes are not created from other adipocytes, but they arise from precursor cells. In the last two decades, scientists have discovered the function of many proteins that influence the ability of precursor cells to become adipocytes. If the expansion of the adipose tissue is the problem, it seems logical that adipocyte development inhibitors could be a viable anti-obesity therapeutic. However, factors that block adipocyte development and limit adipocyte expansion also impair metabolic health. This notion may be counterintuitive, but several lines of evidence support the idea that blocking adipocyte development is unhealthy. For this reason it is clear that we need a better understanding of adipocyte development." | ||
* '''Brown adipose tissue: function and physiological significance'''<ref name=PMID14715917><pubmed>14715917</pubmed></ref> "The function of brown adipose tissue is to transfer energy from food into heat; physiologically, both the heat produced and the resulting decrease in metabolic efficiency can be of significance. ... The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings." | * '''Brown adipose tissue: function and physiological significance'''<ref name=PMID14715917><pubmed>14715917</pubmed></ref> "The function of brown adipose tissue is to transfer energy from food into heat; physiologically, both the heat produced and the resulting decrease in metabolic efficiency can be of significance. ... The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings." | ||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Adipose+Embryology ''Adipose Embryology''] | |||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Brown+Adipose ''Brown Adipose''] | |||
<pubmed limit=5>Brown Embryology</pubmed> | |||
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==Molecular Development== | ==Molecular Development== |
Revision as of 21:50, 21 June 2016
Embryology - 19 Apr 2024 Expand to Translate |
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Introduction
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Connective tissues in the body have a mesoderm origin, while in the head neural crest also contributes to these tissues.
This topic is also covered in musculoskeletal (Tendon Development), integumentary (Integumentary Development) and endocrine development (Adipose Tissue).
Blood is a liquid connective tissue (More? Blood Development).
- Loose and dense connective tissue
- Reticular connective tissue
- Adipose Tissue
- Mesenchymal connective tissue
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Adipose Embryology <pubmed limit=5>Adipose Embryology</pubmed> Search term: Brown Adipose <pubmed limit=5>Brown Embryology</pubmed> |
Molecular Development
Adipocyte differentiation regulation.[1]
White Adipose
Brown Adipose
- Brown Adipose Tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle,
- Brown adipocytes have numerous small lipid droplets rather than a single large one as in white adipocytes
- Elevated numbers of mitochondria
- mitochondrial expression of the nuclear gene UCP1, the uncoupler of oxidative phosphorylation responsible for non-shivering thermogenesis.
Development Overview
Mesoderm Development
Somite - Dermatome
The dermis and hypodermis layers of the skin.
Somatic Mesoderm
The body wall connective tissue.
Splanchnic Mesoderm
The lamina propria and submucosa layers of the gastrointestinal tract wall.
References
- ↑ 1.0 1.1 <pubmed>23209380</pubmed>| PMC3507952 | PLoS Biol.
- ↑ <pubmed>14715917</pubmed>
Reviews
<pubmed>21372557</pubmed> <pubmed>19896888</pubmed> <pubmed>19188249</pubmed> <pubmed>18793119</pubmed> <pubmed>14715917</pubmed>
Articles
<pubmed>20678241</pubmed> <pubmed>17507398</pubmed>
Search PubMed
Search Pubmed: adipose Development
Additional Images
Terms
Glossary Links
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Cite this page: Hill, M.A. (2024, April 19) Embryology Adipose Tissue Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Adipose_Tissue_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G