Abnormal Development - Zika Virus

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Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.

Introduction

Zika virus world map (CDC 2016)

Zika virus (ZIKV) is a mosquito-borne flavivirus related to dengue virus first isolated from a rhesus monkey in Zika forest, Uganda (1947). Transmitted by mosquitoes (Aedes aegypti) it was then identified in humans in Nigeria in 1954 and subsequently in South America, Asia and Pacific regions. More recently in Australia from returning travellers.[1]

Mosquito lifecycle

Mosquito bites lead to an initial infection of skin cells.[2] The virus may also be transmitted transplacentally or during delivery.[3] Some limited evidence, from Brazil, for association with microcephaly.


Viral Links: viral infection | TORCH | cytomegalovirus | hepatitis | HIV | parvovirus | polio | rubella virus | chickenpox | Lymphocytic Choriomeningitis Virus | Zika virus | human papillomavirus | rotavirus | West Nile virus | varicella virus | vaccination | zoonotic infection | environment
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects

Some Recent Findings

More recent papers
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Search term: Abnormal Development Zika Virus

<pubmed limit=5>Abnormal Development Zika Virus</pubmed>

Search term: Zika Virus

<pubmed limit=5>Zika Virus</pubmed>

Virus Structure

Virus particles are 40 nm in diameter, with an outer envelope, and an inner dense core. ZIKV is an RNA virus containing 10,794 nucleotides encoding 3,419 amino acids.[5]

Zika virus TEM01.jpgZika virus TEM02.jpg

Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Paramyxoviridae; Paramyxovirinae; Morbillivirus; Measles virus



Zika History

Zika virus (ZIKV) is a mosquito-borne flavivirus related to dengue virus first isolated from a rhesus monkey in Zika forest, Uganda (1947). Transmitted by mosquitoes (Aedes aegypti) it was then identified in humans in Nigeria in 1954 and subsequently in South America, Asia and Pacific regions. More recently in Australia from returning travellers.[6]

References

  1. <pubmed>24944843</pubmed>
  2. <pubmed>26085147</pubmed>
  3. <pubmed>24721538</pubmed>
  4. <pubmed>25576992</pubmed>
  5. <pubmed>16223950</pubmed>
  6. <pubmed>24944843</pubmed>

Textbooks


Reviews

<pubmed>26674815</pubmed>

Articles

<pubmed>26689277</pubmed>


Search Pubmed

Search Pubmed: Zika Virus | Microcephaly



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Cite this page: Hill, M.A. (2021, October 28) Embryology Abnormal Development - Zika Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Zika_Virus

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G