Abnormal Development - Zika Virus

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Introduction

Zika virus world map (CDC 2016)

Zika virus (ZIKV) is a mosquito-borne flavivirus related to dengue virus first isolated from a rhesus monkey in Zika forest, Uganda (1947). Transmitted by mosquitoes (Aedes aegypti) it was then identified in humans in Nigeria in 1954 and subsequently in South America, Asia and Pacific regions. More recently in Australia from returning travellers.[1]

Mosquito lifecycle

Mosquito bites lead to an initial infection of skin cells.[2] The virus may also be transmitted transplacentally or during delivery.[3] Some limited evidence, from Brazil, for association with microcephaly.


Viral Links: viral infection | TORCH | cytomegalovirus | hepatitis | HIV | parvovirus | polio | rubella virus | chickenpox | Lymphocytic Choriomeningitis Virus | Zika virus | human papillomavirus | rotavirus | West Nile virus | varicella virus | vaccination | zoonotic infection | environment
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects

Some Recent Findings

More recent papers
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Search term: Abnormal Development Zika Virus

<pubmed limit=5>Abnormal Development Zika Virus</pubmed>

Search term: Zika Virus

<pubmed limit=5>Zika Virus</pubmed>

Virus Structure

Virus particles are 40 nm in diameter, with an outer envelope, and an inner dense core. ZIKV is an RNA virus containing 10,794 nucleotides encoding 3,419 amino acids.[5]

Zika virus Pika virions (red circles)
Zika virus TEM01.jpg Zika virus TEM02.jpg

Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Paramyxoviridae; Paramyxovirinae; Morbillivirus; Measles virus

Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus; Spondweni virus group.


Zika History

Zika virus (ZIKV) is a mosquito-borne flavivirus related to dengue virus first isolated from a rhesus monkey in Zika forest, Uganda (1947). Transmitted by mosquitoes (Aedes aegypti) it was then identified in humans in Nigeria in 1954 and subsequently in South America, Asia and Pacific regions. More recently in Australia from returning travellers.[6]

References

  1. <pubmed>24944843</pubmed>
  2. <pubmed>26085147</pubmed>
  3. <pubmed>24721538</pubmed>
  4. <pubmed>25576992</pubmed>
  5. <pubmed>16223950</pubmed>
  6. <pubmed>24944843</pubmed>

Textbooks


Reviews

<pubmed>26674815</pubmed>

Articles

<pubmed>26689277</pubmed>


Search Pubmed

Search Pubmed: Zika Virus | Microcephaly



Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | zoonotic infection | toxoplasmosis | Malaria | maternal diabetes | maternal hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | hypoxia | biological toxins | chemicals | heavy metals | air pollution | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis


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Cite this page: Hill, M.A. (2024, March 28) Embryology Abnormal Development - Zika Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Zika_Virus

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G