Abnormal Development - Teratogens: Difference between revisions
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* '''Teratogen Screening Using Transcriptome Profiling of Differentiating Human Embryonic Stem Cells'''<ref><pubmed>20561110</pubmed></ref> "Teratogens are substances that may cause defects in normal embryonic development while not necessarily being toxic in adults. Identification of possible teratogenic compounds has been historically beset by the species-specific nature of the teratogen response. To examine teratogenic effects on early human development we performed non-biased expression profiling of differentiating human embryonic and induced-pluripotent stem cells treated with several drugs; ethanol, lithium, retinoic acid, caffeine and thalidomide, which is known to be highly species specific. Our results point to the potency of specific teratogens and their affected tissues and pathways. Specifically, we could show that ethanol caused dramatic increase in endodermal differentiation, retinoic acid caused misregulation of neural development, and thalidomide affected both these processes. We thus propose this method as a valuable addition to currently available animal screening approaches." | |||
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Revision as of 00:30, 19 October 2010
Introduction
How and why do things go wrong in development? Embryological development is a robust biological system able to cope with many stresses without long-term consequences. When development does go wrong there are generally 3 major types groups: Genetic (inherited), Environmental (maternal) derived and Unknown (not determined or known) abnormalities. Also often not considered, is that pregnancy itself can also expose abnormalities in the mother (congenital heart disease, diabetes, reproductive disorders) that until the pregnancy had gone undetected.
- Infections, collectively grouped under the acronym TORCH for Toxoplasmosis, Other organisms (parvovirus, HIV, Epstein-Barr, herpes 6 and 8, varicella, syphilis, enterovirus) , Rubella, Cytomegalovirus and Hepatitis. See also the related topics on maternal hyperthermia and bacterial infections.
- Maternal diet the best characterised is the role of low folic acid and Neural Tube Defects (NTDs) see also abnormal neural development and Neural Tube Defects (NTDs). More recently the focus has been on dietary iodine levels and the role they also play on neural development.
- Maternal drugs effects either prescription drugs (therapeutic chemicals/agents, thalidomide limb development), non-prescription drugs (smoking), and illegal drugs (Cannabis/Marijuana, Methamphetamine/Amphetamine, Cocaine, Heroin, Lysergic Acid Diethylamide)
- Environment (smoking, chemicals, heavy metals, radiation) and maternal endocrine function (maternal diabetes, thyroid development) and maternal stress.
- Teratogen synergism, different environmental effects can act individually or in combination on the same developing system. For example, neural development can be impacted upon by alcohol (fetal alcohol syndrome), viral infection (rubella) and/or inadequate dietry folate intake (neural tube defects). These effects may also not be seen as a direct effect on a system or systems but result in a reduced birth weight and the potential postnatal developmental effects. Consider also this in relation to the increasing support to the fetal origins hypothesis.
Use the page links below to explore specific teratogens.
Some Recent Findings
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Critical Periods of Development
- Finally, when studying this topic remember the concept of critical periods of development that will affect the overall impact of the above listed factors. This can be extended to the potential differences between prenatal and postnatal effects, for example with infections and outcomes.
Conceptus | Embryonic development (weeks) | Fetal period (weeks) | |||||||||||||||||
Neural | |||||||||||||||||||
Heart | |||||||||||||||||||
Upper limbs | |||||||||||||||||||
Lower limbs | |||||||||||||||||||
Ear | |||||||||||||||||||
Eye | |||||||||||||||||||
Palate | |||||||||||||||||||
Teeth | |||||||||||||||||||
External genitalia | |||||||||||||||||||
Loss | Major abnormalities | Functional and Minor abnormalities |
References
- ↑ <pubmed>20561110</pubmed>
Journals
- Birth Defects Research Part A: Clinical and Molecular Teratology
- Birth Defects Research Part B: Developmental and Reproductive Toxicology
- Part C: Embryo Today: Reviews
Reviews
Articles
Search Pubmed
Search Pubmed: teratogen | teratogenesis
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 19) Embryology Abnormal Development - Teratogens. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Teratogens
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G