Abnormal Development - Rotavirus: Difference between revisions

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===Reviews===
===Reviews===
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===Articles===
===Search PubMed===
Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Rotavirus ''Rotavirus'']


== External Links ==
== External Links ==

Revision as of 11:32, 24 February 2018

Embryology - 29 Mar 2024    Facebook link Pinterest link Twitter link  Expand to Translate  
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Introduction

Rotavirus (CDC)

A type of virus that is a common cause of diarrhoea and vomiting (viral gastroenteritis) in infants and young children. The live attenuated rotavirus vaccine is contraindicated in pregnancy, but can be safely administered to household contacts of pregnant women. There is only a very small risk of transmission of the rotavirus vaccine virus to a susceptible pregnant woman and there is no evidence of risk to the fetus if pregnant women are in contact with recently vaccinated individuals.



(data based on: The Australian Immunisation Handbook 9th Edition 2008 2.3.2 Vaccination of women planning pregnancy, pregnant or breastfeeding women, and preterm infants - updated July 2009 )

Viral Links: viral infection | TORCH | cytomegalovirus | hepatitis | HIV | parvovirus | polio | rubella virus | chickenpox | Lymphocytic Choriomeningitis Virus | Zika virus | human papillomavirus | rotavirus | West Nile virus | varicella virus | vaccination | zoonotic infection | environment
Historic Embryology - Viral 
1941 Rubella Cataracts | 1944 Rubella Defects


Links: Abnormal Development - Rotavirus | Postnatal - Vaccination | The Australian Immunisation Handbook 9th Edition 2008 | Australian Immunisation Handbook - Rotavirus | 2.3.2 Vaccination of women planning pregnancy, pregnant or breastfeeding women, and preterm infants - updated July 2009 | Medical Microbiology - Rotaviruses

Some Recent Findings

More recent papers  
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Search term: Abnormal Development Rotavirus

<pubmed limit=5>Abnormal Development Rotavirus</pubmed>

Search term: Rotavirus

<pubmed limit=5>Rotavirus</pubmed>

Discovery of Rotavirus

Ruth Bishop (c 1980)

Best summarised in the 2009 paper by Ruth Bishop, who in 1973 was one of original discoverers of the virus.[1]

"For centuries, acute diarrhea has been a major worldwide cause of death in young children, and until 1973, no infectious agents could be identified in about 80% of patients admitted to hospital with severe dehydrating diarrhea. In 1973 Ruth Bishop, Geoffrey Davidson, Ian Holmes, and Brian Ruck identified abundant particles of a 'new' virus (rotavirus) in the cytoplasm of mature epithelial cells lining duodenal villi and in feces, from such children admitted to the Royal Children's Hospital, Melbourne. Rotaviruses have now been shown to cause 40-50% of severe acute diarrhea in young children worldwide in both developing and developed countries, and > 600 000 young children die annually from rotavirus disease, predominantly in South-East Asia and sub-Saharan Africa. Longitudinal surveillance studies following primary infection in young children have shown that rotavirus reinfections are common. However the immune response that develops after primary infection is protective against severe symptoms on reinfection. This observation became the basis for development of live oral rotavirus vaccines"

Virus Structure

  • Non-enveloped, icosahedral virus of the Reoviridae family containing a genome of 11 segments of double stranded RNA (dsRNA).
  • Divided into seven serotypes (Rotavirus A–G).
Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | zoonotic infection | toxoplasmosis | Malaria | maternal diabetes | maternal hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | hypoxia | biological toxins | chemicals | heavy metals | air pollution | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis


References

  1. Bishop R. (2009). Discovery of rotavirus: Implications for child health. J. Gastroenterol. Hepatol. , 24 Suppl 3, S81-5. PMID: 19799704 DOI.


Reviews

Desselberger U. (2017). Differences of Rotavirus Vaccine Effectiveness by Country: Likely Causes and Contributing Factors. Pathogens , 6, . PMID: 29231855 DOI.

Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, Franco MA, Greenberg HB, O'Ryan M, Kang G, Desselberger U & Estes MK. (2017). Rotavirus infection. Nat Rev Dis Primers , 3, 17083. PMID: 29119972 DOI.

Articles

Search PubMed

Search term: Rotavirus

External Links

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Cite this page: Hill, M.A. (2024, March 29) Embryology Abnormal Development - Rotavirus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Rotavirus

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G