Abnormal Development - Maternal Inflammation: Difference between revisions
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* '''Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.'''<ref><pubmed> | * '''Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse.'''<ref><pubmed>21935422</pubmed></ref> "Cellular uptake of proteins from the cerebrospinal fluid was observed in brains from lipopolysaccharide-treated animals in radial progenitor cells. However, the foetal blood-brain barrier to plasma proteins remained intact. Together, these results indicate that maternal inflammation can disrupt the ventricular surface and lead to decreased cellular proliferation. Changes in cell density in Layers IV and V at post-natal Day 8 show that these initial changes have prolonged effects on cortical organization. The possible shift in the fate of progeny and the resulting alterations in the relative cell numbers in the cerebral cortex following a maternal inflammatory response shown here will require further investigation to determine the long-term consequences of inflammation on the development of neuronal circuitry and behaviour." | ||
* '''Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice'''<ref><pubmed>21964917</pubmed></ref> "These results demonstrate that systemic maternal inflammation combined with neonatal hyperoxia exposure induces alterations in cardiac structure and function leading to cardiac failure in adulthood and supports the importance of the intrauterine and neonatal milieu on adult health." | |||
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==References== | ==References== |
Revision as of 08:12, 17 February 2012
Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose. |
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<pubmed>21376162</pubmed> <pubmed>21771319</pubmed> <pubmed>16489598</pubmed>
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Cite this page: Hill, M.A. (2024, April 25) Embryology Abnormal Development - Maternal Inflammation. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Maternal_Inflammation
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G