Abnormal Development - Malaria
Embryology - 25 Apr 2024 Expand to Translate |
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Introduction
About 10,000 women and 200,000 babies die annually because of malaria in pregnancy, which can cause miscarriages, preterm births, and low-birth-weight births.[1] There are about 156 species of Plasmodium which infect different vertebrate species. In humans there are four types of malaria caused by the protozoan parasite Plasmodium falciparum (main), Plasmodium vivax, Plasmodium ovale, Plasmodium malariae.
These malarial parasites are carried by the female mosquito (anopheles species) and about 100 different species can transmit human malaria. When an infected mosquito bites a human, the parasites can enter the bloodstream and travel for about an hour before entering the liver and then multiplying. Between 6 to 16 days (depending on the species), the parasites reenter the bloodstream to invade and multiply inside red blood cells (RBCs). These infected RBCs rupture and released more parasites that infect and destroy further RBCs.
Placental infection is common in regions where malaria is endemic with women carrying their first pregnancy (primigravida). (More? Placenta - Abnormalities)
Global limits and endemicity of P. falciparum in 2007 |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Maternal Malaria <pubmed limit=5>Maternal Malaria</pubmed> |
Mosquito Lifecycle
Placental Malaria
Pregnant women have an increased susceptibility to malaria infection. Malarial infection of the placenta by sequestration of the infected red blood cells leading to low birth weight and other effects.
- Several infective agents may cross into the placenta from the maternal circulation, as well as enter the embryo/fetal circulation.
- Pregnant women have an increased susceptibility to malaria infection.
- Malarial infection of the placenta by sequestration of the infected red blood cells leading to low birth weight and other effects.
Mouse Model
Mouse E18 neurovasculature MicroCT[2]
References
Books
- Guidelines for the Treatment of Malaria. 3rd edition. Geneva: World Health Organization; 2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK294440/
- Bioinformatics in Tropical Disease Research: A Practical and Case-Study Approach Gruber, Arthur; Durham, Alan M.; Huynh, Chuong; del Portillo, Hernando A., editors Bethesda (MD): National Library of Medicine (US), NCBI; 2008 Control of Gene Expression in Plasmodium
Reviews
<pubmed>24388420</pubmed> <pubmed>18165470</pubmed> <pubmed>17251081</pubmed> <pubmed>16265906</pubmed>
Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>
Search PubMed
Search Pubmed: Placental Malaria
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- CDC Division of Parasitic Diseases and Malaria Malaria
- Toronto General Hospital/Research Institute Kevin Kain
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Cite this page: Hill, M.A. (2024, April 25) Embryology Abnormal Development - Malaria. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Malaria
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G