Abnormal Development - Lassa Virus: Difference between revisions

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Notice - Mark Hill

Currently this page is only a template and will be updated (this notice removed when completed).

Introduction

Lassa virus

Lassa virus is a member of the virus family Arenaviridae, a single-stranded RNA virus. The virus is the causative agent of a hemorrhagic fever and can be transmitted between species (zoonotic). Discovered in 1969 when two missionary nurses died in Nigeria and today still occurs mainly in West Africa.

Death rates are high for women in the third trimester of pregnancy. Fetal death (95%) occurs in uterus of infected pregnant mothers.

Historic Embryology - Viral
1941 Rubella Cataracts \| 1944 Rubella Defects

Some Recent Findings

Emerging trends in Lassa Fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection^[1] "Only Lassa virus (LASV) viremia assessed by Ag-capture immunoassay, nucleic acid detection or virus isolation should be used to diagnose acute LASV infection in West Africans. LASV-specific IgM serostatus cannot be considered a diagnostic marker of acute Lassa fever (LF) in suspected cases living in endemic areas of West Africa. By applying these criteria, we identified a dysregulated metabolic and pro-inflammatory response profile conferring a poor prognosis in acute LF. In addition to suggesting that the current diagnostic paradigm for acute LF should be reconsidered, these studies present new opportunities for therapeutic interventions based on potential prognostic markers in LF."

References

↑ <pubmed>22023795</pubmed>

Reviews

Articles

Search Pubmed

June 2010

Search Pubmed: Lassa Virus |

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Infectious Disease Society of America (IDSA)

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Cite this page: Hill, M.A. (2024, April 19) Embryology Abnormal Development - Lassa Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Lassa_Virus

What Links Here?

[1] <pubmed>22023795</pubmed>

[1]

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+* '''Emerging trends in Lassa Fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection'''<ref><pubmed>22023795</pubmed></ref> "Only Lassa virus (LASV) viremia assessed by Ag-capture immunoassay, nucleic acid detection or virus isolation should be used to diagnose acute LASV infection in West Africans. LASV-specific IgM serostatus cannot be considered a diagnostic marker of acute Lassa fever (LF) in suspected cases living in endemic areas of West Africa. By applying these criteria, we identified a dysregulated metabolic and pro-inflammatory response profile conferring a poor prognosis in acute LF. In addition to suggesting that the current diagnostic paradigm for acute LF should be reconsidered, these studies present new opportunities for therapeutic interventions based on potential prognostic markers in LF."
 |}