Abnormal Development - Fetal Origins Hypothesis: Difference between revisions
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* '''Perinatal Risk Factors for Diabetes in Later Life'''<ref><pubmed>19066311</pubmed></ref> "Low birth weight is consistently associated with an increased risk of non-insulin dependent diabetes mellitus in adulthood, but the individual contributions from poor fetal growth and preterm birth are not known. ....Our results suggest that the association between low birth weight and diabetes is due to factors associated with both poor fetal growth and short gestational age." | * '''Perinatal Risk Factors for Diabetes in Later Life'''<ref><pubmed>19066311</pubmed></ref> "Low birth weight is consistently associated with an increased risk of non-insulin dependent diabetes mellitus in adulthood, but the individual contributions from poor fetal growth and preterm birth are not known. ....Our results suggest that the association between low birth weight and diabetes is due to factors associated with both poor fetal growth and short gestational age." | ||
* '''Persistent epigenetic differences associated with prenatal exposure to famine in humans'''<ref><pubmed>18955703</pubmed></ref> "Here we show that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944-45 had, 6 decades later, less DNA methylation of the imprinted IGF2 gene compared with their unexposed, same-sex siblings. The association was specific for periconceptional exposure, reinforcing that very early mammalian development is a crucial period for establishing and maintaining epigenetic marks." (More? see also [[Molecular Development - Epigenetics]]) | * '''Persistent epigenetic differences associated with prenatal exposure to famine in humans'''<ref><pubmed>18955703</pubmed></ref> "Here we show that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944-45 had, 6 decades later, less DNA methylation of the imprinted IGF2 gene compared with their unexposed, same-sex siblings. The association was specific for periconceptional exposure, reinforcing that very early mammalian development is a crucial period for establishing and maintaining epigenetic marks." (More? see also [[Molecular Development - Epigenetics]]) | ||
* '''The fetal origins hypothesis—10 years on (2005)'''<ref><pubmed>15891207</pubmed></ref>"In 1995 David Barker wrote: “The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease.”1 Now, 10 years later, the importance of events before birth for lifetime health has been confirmed in many populations." | |||
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Revision as of 13:33, 10 October 2010
Introduction
Maternal derived abnormalities relate to lifestyle, environment and nutrition and while some of these directly effect embryonic development, there is also growing evidence that some effects are more subtle and relate to later life health events. This theory is based on the early statistical analysis carried out by Barker of low birth weight data collected in the early 1900's in the south east of England which he then compared with these same babies later health outcomes. The theory was therefore originally called the "Barker Hypothesis" and has recently been renamed as "fetal origins" or "programming".
There have also been some issues relating to how the data is both collected and analyzed. (see Lucas reference)
Some Recent Findings
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Barker Hypothesis
There were some key papers that initially studied UK birth weight data by Barker that gave rise to this area of research.[5][6][7]
Environmental influences originate in utero
Hypothesis proposes influences cause permanent changes in embryo/fetus, low birth weight, predisposition to chronic disease in adult life.
Malnutrition in utero affects brain development, "low birth weight" or intrauterine growth restricted babies fare less well on measures of mental development in later life studies compared low birth weight babies (<2500 g) with controls, show impairment in neuro developmental tests up to age 11
Intelligence is a combination of genetic and environmental influences (relative contributions of which are not yet established) and may vary over lifespan.
Modified Text from: Arch Dis Child 2001;85:189-196
NCBI Bookshelf
Resources available from online textbooks freely available at National Library of Medicine (USA), National Center for Biotechnology Information.
Health Services/Technology Assessment Text (HSTAT)
Evidence table 5B. Studies Evaluating Association of LBW of Audiology Outcomes Part II
Birth Terms
- Premature infant
- An infant born before 37 weeks of estimated gestational age
- Low birth weight
- Birth weight < 2,500 g (5 lb, 8 oz)
- Very low birth weight
- Birth weight < 1,500 g (3 lb, 5 oz)
- Extremely low birth weight
- Birth weight < 1,000 g (2 lb, 3 oz)
References
Search Pubmed
Search Pubmed - fetal origins hypothesis
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Cite this page: Hill, M.A. (2024, March 28) Embryology Abnormal Development - Fetal Origins Hypothesis. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Fetal_Origins_Hypothesis
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G