Abnormal Development - Cytomegalovirus: Difference between revisions
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:'''Links:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genome&Cmd=ShowDetailView&TermToSearch=17910 Genome] | [http://www.ncbi.nlm.nih.gov/nuccore/AY446894.2 Sequence] | :'''Links:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genome&Cmd=ShowDetailView&TermToSearch=17910 Genome] | [http://www.ncbi.nlm.nih.gov/nuccore/AY446894.2 Sequence] | ||
==Cytomegalovirus Detection== | |||
[[File:Cytomegalovirus.jpg]] | |||
Immunoflourescent detection of Cytomegalovirus.Image shows human embryonic lung infected by cytomegalovirus demonstrated by an immunofluorescent technique. Viral infection causes systemic infection and extensive brain damage and cell death by necrosis. | |||
==Cytomegalovirus History== | ==Cytomegalovirus History== | ||
Revision as of 10:01, 1 November 2011
Introduction
Human cytomegalovirus (HCMV, Greek, cyto = "cell", megalo = "large") or Human Herpesvirus 5 (HHV-5) is a member of the herpes virus family. A viral infection that causes systemic infection and extensive brain damage and cell death by necrosis. Cytomegalovirus is the leading cause of congenital viral infection, with a range of incidence between 0·5–3% of live births worldwide. Neonates with congenital or perinatal cytomegalovirus infection can be asymptomatic and infection can also be transmitted postnatally from mother to infant by breastfeeding.
HCMV infection is ranked as one of the most common infections in adults, with the seropositive rates ranging from 60–99% globally. In Western countries, adults with advanced AIDS prior to the introduction of highly active antiretroviral therapy (HAART) this virus also a cause of blindness (CMV retinitis) and death in patients.
Some Recent Findings
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Cytomegalovirus Structure
- double-stranded linear DNA virus
- 235 Kb in size
Cytomegalovirus infected spermatozoa nucleus[1]
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| Full and empty viral capsids | HCMV virions |
Cytomegalovirus Detection
Immunoflourescent detection of Cytomegalovirus.Image shows human embryonic lung infected by cytomegalovirus demonstrated by an immunofluorescent technique. Viral infection causes systemic infection and extensive brain damage and cell death by necrosis.
Cytomegalovirus History
- 1921 - first to suggest that the "cytomegalia" could be due to a viral agent.
- 1950 - demonstrated that infection may occur in utero.
- 1956-57 - several groups independently isolate human CMV strains.
- 1960 - the term "cytomegalovirus" introduced.
References
- ↑ 1.0 1.1 <pubmed>21711549</pubmed>| Herpesviridae.
- ↑ PMID 21631642
Textbooks
- Medical Microbiology. 4th edition. Baron S, editor. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Medical Microbiology- Cytomegalovirus | Search Medical Microbiology "Cytomegalovirus"
- Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Viruses Exploit Host Cell Machinery for All Aspects of Their Multiplication
- Disease Control Priorities in Developing Countries. 2nd edition. Jamison DT, Breman JG, Measham AR, et al., editors. Washington (DC): World Bank; 2006. Chapter 20Vaccine-preventable Diseases
Reviews
<pubmed>21375790</pubmed> <pubmed>18073181</pubmed> <pubmed>17635529</pubmed> <pubmed>12364375</pubmed>
Articles
<pubmed>9042169</pubmed>
Search Pubmed
Search Pubmed: Cytomegalovirus Virus | Congenital Cytomegalovirus Syndrome | Congenital Cytomegalovirus Infection
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Cite this page: Hill, M.A. (2024, April 16) Embryology Abnormal Development - Cytomegalovirus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Cytomegalovirus
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
