Abnormal Development - Cytomegalovirus: Difference between revisions

Revision as of 14:41, 20 August 2011

Introduction

Cytomegalovirus

Human cytomegalovirus (HCMV, Greek, cyto = "cell", megalo = "large") or Human Herpesvirus 5 (HHV-5) is a member of the herpes virus family. A viral infection that causes systemic infection and extensive brain damage and cell death by necrosis. Cytomegalovirus is the leading cause of congenital viral infection, with an range of incidence between 0·5–3% of live births worldwide.

HCMV infection is ranked as one of the most common infections in adults, with the seropositive rates ranging from 60–99% globally. In Western countries, adults with advanced AIDS prior to the introduction of highly active antiretroviral therapy (HAART) this virus also a cause of blindness (CMV retinitis) and death in patients.

Some Recent Findings

Update on the prevention, diagnosis and management of cytomegalovirus infection during pregnancy^[1] "Given the high risk of mother-fetus transmission and fetal damage, prenatal diagnosis is recommended to women with primary CMV infection contracted in the first half of pregnancy and in case of fetal abnormalities suggestive of infection. The correct interpretation of serological and virological tests followed by appropriate counselling by an expert physician is an effective tool to reduce the number of unnecessary pregnancy terminations by over 70% (Am J Obstet Gynecol 2007; 196: 221.e1)."

Cytomegalovirus Structure

double-stranded linear DNA virus
235 Kb in size

Links: Genome | Sequence

Cytomegalovirus History

1921 - first to suggest that the "cytomegalia" could be due to a viral agent.
1950 - demonstrated that infection may occur in utero.
1956-57 - several groups independently isolate human CMV strains.
1960 - the term "cytomegalovirus" introduced.

References

↑ PMID 21631642

Textbooks

Medical Microbiology. 4th edition. Baron S, editor. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Medical Microbiology- Cytomegalovirus | Search Medical Microbiology "Cytomegalovirus"
Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Viruses Exploit Host Cell Machinery for All Aspects of Their Multiplication
Disease Control Priorities in Developing Countries. 2nd edition. Jamison DT, Breman JG, Measham AR, et al., editors. Washington (DC): World Bank; 2006. Chapter 20Vaccine-preventable Diseases

Reviews

Articles

Search Pubmed

Search Pubmed: Cytomegalovirus Virus | Congenital Cytomegalovirus Syndrome | Congenital Cytomegalovirus Infection

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

Glossary Links

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Cite this page: Hill, M.A. (2024, April 16) Embryology Abnormal Development - Cytomegalovirus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Cytomegalovirus

What Links Here?

[1] PMID 21631642

[1]

@@ Line 24: / Line 24: @@
 ==Cytomegalovirus History==
-* 1921 - Goodpasture and Talbert first to suggest that the "cytomegalia" could be due to a viral agent.
+* '''1921''' - first to suggest that the "cytomegalia" could be due to a viral agent.
-* '''1950''' - Smith and Vellios showed that infection may occur in utero.
+* '''1950''' - demonstrated that infection may occur in utero.
 * '''1956-57''' - several groups independently isolate human CMV strains.
 * '''1960''' - the term "cytomegalovirus" introduced.