ANAT2341 Lab 8: Difference between revisions

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{{ANAT2341Lab8}}
==Skin Development and Regeneration==
==Urogenital Development==
This practical will introduce the topic of urogenital differentiation during development through a series of online resource pages.


'''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation.
1. QUIZ


'''Key Concepts:''' Intermediate mesoderm, primordial germ cells, renal development, bladder development, gonad, internal genitalia, external genitalia, ovary, testes, puberty, hormonal changes, gametogenesis, abnormalities.
2. Dr. Annemiek Beverdam (UNSW) - "Stem cell regulation in normal skin regeneration and in skin disease"
[[File:Annemiek Beverdam profile photo.jpeg]]


==Background==
Dr. Annemiek Beverdam studies the genetic processes that govern development, homeostasis and regeneration of the skin in the mouse. Her research aims at understanding the genetic and molecular basis of developmental and human regenerative skin diseases such as skin cancer, which affects 2 out of 3 Australians in their life time. Her lab recently made the pivotal discoveries that Yes-associated protein (YAP) functions acts as a key molecular switch in epidermal stem/progenitor cell proliferation and differentiation [https://www.ncbi.nlm.nih.gov/pubmed/23190885] by driving β-Catenin Activation [https://www.ncbi.nlm.nih.gov/pubmed/27816394]. Dr. Beverdam currently investigates the developmental genetic context in which YAP functions to control skin stem/progenitor cells in normal and in disrupted skin biology. She employs genetically manipulated mouse models, human skin samples, advanced imaging technology such as confocal microscopy and whole mouse in vivo imaging, gene and protein expression analyses and whole genome approaches to address her research questions. Her research will open up exciting new avenues for translational research and the development of treatments for human regenerative skin disease such as skin cancer and eczema.
{|
| [[File:Historic-testis.jpg|140px]]
 
[[File:Historic-ovary.jpg|200px]]
 
'''Historic Gonad Images'''
| valign="top" | Two key systems, neural and reproductive, develop over an extended period from the early embryo to puberty and the emerging adult. The genital system is closely linked developmentally to the urinary system, often called the urogenital system. This practical will therefore cover early development of both system.
 
In understanding embryonic sexual development, think of a cascade of sequence dependent events that transform indifferent gonads, internal and external genitalia into distinct male and female structures.
 
The process begins with gonad differentiation, which itself is tied developmentally back at the initial event of fertilization and the presence of either a Y or X chromosome in the sperm.
 
The endpoint of development could be considered the post-puberty active reproductive system. Interestingly, recent research is pointing to a link between neural and reproductive systems in how male and female brains may differentially develop under the influence of sex hormones and perhaps even the sex chromosomes.
 
 
* There are 6 pages to work through in today's practical class, listed at the top and bottom of each page.
* Additional information sections are not part of the practical class content.
|}
 
==Genital Timeline==
''These are approximate timings and stages only.''
 
* [[Carnegie stage 11|24 days]] - intermediate mesoderm, pronephros primordium
* [[Carnegie stage 13|28 days]] - mesonephros and mesonephric duct
* [[Carnegie stage 15|35 days]] - uteric bud, metanephros, urogenital ridge
* [[Carnegie stage 17|42 days]] - cloacal divison, gonadal primordium (indifferent)
* [[Carnegie stage 19|49 days]] - paramesonephric duct, gonadal differentiation
* [[Carnegie stage 23|56 days]] - paramesonephric duct fusion (female)
* 100 days - primary follicles (ovary)
 
==Textbooks==
{|
|-
| [[File:Logo.png|80px]]
| {{Embryo citation}}
 
{{Renal Links}}
 
{{Genital Links}}
|-
| [[File:The Developing Human, 8th edn.jpg|80px]]
| Moore, K.L. &amp; Persuad, T.V.N. (2008). <i>The Developing Human: clinically oriented embryology</i> (8<sup>th</sup> ed.). Philadelphia: Saunders.
 
The following chapter links only work with a UNSW connection and can also be accessed through this  [http://searchfirst.library.unsw.edu.au/primo_library/libweb/action/search.do?vid=UNSW&amp;fn=search&amp;vl(freeText0)=UNSW_SFX14190000000048007 UNSW Library connection].
* [http://www.mdconsult.com/books/linkTo?type=bookPage&amp;isbn=978-1-4160-3706-4&amp;eid=4-u1.0-B978-1-4160-3706-4..50015-3 Chapter 12 - The Urogenital System]
|-
| {{MPT2015cover_citation}}
| The following chapter links only work with UNSW Library subscription (with student Zpass log-in).
*  [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074524&pg=412 Chapter 15 - Development of the Reproductive System]
|-
| [[File:Larsen's human embryology 5th ed.jpg|50px]]{{Larsen2015APAcitation}}
| The following chapter links only work with UNSW Library subscription (with student Zpass log-in).
*  [http://www.unsw.eblib.com.wwwproxy0.library.unsw.edu.au/patron/Read.aspx?p=2074364&pg=329 Urogenital System]
|-
|}
 
 
{{ANAT2341Lab8}}
 
 
 
{{2016ANAT2341}}

Revision as of 12:06, 13 December 2016

Skin Development and Regeneration

1. QUIZ

2. Dr. Annemiek Beverdam (UNSW) - "Stem cell regulation in normal skin regeneration and in skin disease" Annemiek Beverdam profile photo.jpeg

Dr. Annemiek Beverdam studies the genetic processes that govern development, homeostasis and regeneration of the skin in the mouse. Her research aims at understanding the genetic and molecular basis of developmental and human regenerative skin diseases such as skin cancer, which affects 2 out of 3 Australians in their life time. Her lab recently made the pivotal discoveries that Yes-associated protein (YAP) functions acts as a key molecular switch in epidermal stem/progenitor cell proliferation and differentiation [1] by driving β-Catenin Activation [2]. Dr. Beverdam currently investigates the developmental genetic context in which YAP functions to control skin stem/progenitor cells in normal and in disrupted skin biology. She employs genetically manipulated mouse models, human skin samples, advanced imaging technology such as confocal microscopy and whole mouse in vivo imaging, gene and protein expression analyses and whole genome approaches to address her research questions. Her research will open up exciting new avenues for translational research and the development of treatments for human regenerative skin disease such as skin cancer and eczema.

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