Difference between revisions of "ANAT2341 Lab 8"

From Embryology
(Larsen's Human Embryology)
 
(37 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{ANAT2341Lab8}}
+
'''PRACTICAL CLASS PROGRAM:'''
==Urogenital Development==
+
* Weekly Quiz + revision (10 minutes)
This practical will introduce the topic of urogenital differentiation during development through a series of online resource pages.
+
* Completion of surveys (10 minutes)
 +
* Practical class activities (40 minutes)
 +
* Guest Lecture by A/Prof Stuart Fraser (45 minutes)
 +
* Practical Class Revision (15 minutes)
  
'''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation.
 
  
'''Key Concepts:''' Intermediate mesoderm, primordial germ cells, renal development, bladder development, gonad, internal genitalia, external genitalia, ovary, testes, puberty, hormonal changes, gametogenesis, abnormalities.
+
'''PRACTICAL CLASS ACTIVITIES''' (40 minutes):
 +
* Cell lineage activity
 +
* Investigate the chicken embryo skeletal preps
  
==Background==
 
{|
 
| [[File:Historic-testis.jpg|140px]]
 
  
[[File:Historic-ovary.jpg|200px]]
+
'''LEARNING OBJECTIVES''':
 +
* Understanding organogenesis
 +
* Understanding the developmental paths of cell types/structures
 +
* Understand the developmental basis of human disease
 +
* Understanding skeletal development
 +
* Understanding blood cell development
 +
* Understanding research into blood cell development
  
'''Historic Gonad Images'''
 
| valign="top" | Two key systems, neural and reproductive, develop over an extended period from the early embryo to puberty and the emerging adult. The genital system is closely linked developmentally to the urinary system, often called the urogenital system. This practical will therefore cover early development of both system.
 
  
In understanding embryonic sexual development, think of a cascade of sequence dependent events that transform indifferent gonads, internal and external genitalia into distinct male and female structures.
 
  
The process begins with gonad differentiation, which itself is tied developmentally back at the initial event of fertilization and the presence of either a Y or X chromosome in the sperm.
+
'''Blood Cell Development - A/Prof Stuart Fraser'''
 +
<br><br>
 +
Biographical details
  
The endpoint of development could be considered the post-puberty active reproductive system. Interestingly, recent research is pointing to a link between neural and reproductive systems in how male and female brains may differentially develop under the influence of sex hormones and perhaps even the sex chromosomes.
+
Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan.
 +
Back to Top
  
 +
Stuart's main research interests focus upon the mechanisms controlling the formation of the {{blood}}, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.
  
* There are 6 pages to work through in today's practical class, listed at the top and bottom of each page.
+
==References==
* Additional information sections are not part of the practical class content.
+
{{#pmid:31273739}}
|}
 
  
==Urogenital Timeline==
+
{{#pmid:29076088}}
  
* '''24 days''' - intermediate mesoderm, pronephros primordial
+
{{#pmid:28401096}}
* '''28 days''' - mesonephros and mesonephric duct
 
* '''35 days''' - uteric bud, metanephros, urogenital ridge
 
* '''42 days''' - cloacal divison, gonadal primordium (indifferent)
 
* '''49 days''' - paramesonephric duct, gonadal differentiation
 
* '''56 days''' - paramesonephric duct fusion (female)
 
* '''100 days''' - primary follicles (ovary)
 
  
==Textbooks==
+
{{#pmid:28395744}}
===Embryology===
 
{| border='0px'
 
|-
 
| [[File:Logo.png|80px]]
 
| Hill, M.A. (2012) <i>UNSW Embryology</i> (12<sup>th</sup> ed.). Sydney:UNSW.
 
  
{{Renal Links}} | [[2010_Lecture_15|2010 Lecture]]
+
{{#pmid:26898901}}
  
{{Genital Links}} | [[2010_Lecture_16|2010 Lecture]]
+
{{#pmid:26113865}}
  
|}
+
Search PubMed: [https://www.ncbi.nlm.nih.gov/pubmed/?term=Fraser%20ST%5BAuthor%5D&cauthor=true&cauthor_uid=31273739 Fraser ST]
===The Developing Human: Clinically Oriented Embryology===
 
{|
 
|-
 
| [[File:The Developing Human, 9th edn.jpg|90px]]
 
| '''Citation:''' The Developing Human: clinically oriented embryology 9<sup>th</sup> ed. Keith L. Moore, T.V.N. Persaud, Mark G. Torchia. Philadelphia, PA: Saunders, 2011. (links available to UNSW students)
 
* [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-2002-0..00012-6&isbn=978-1-4377-2002-0&uniqId=330028653-2#4-u1.0-B978-1-4377-2002-0..00012-6 Chapter 12 - Urogenital System]
 
|}
 
===Larsen's Human Embryology===
 
{| border='0px'
 
|-
 
| [[File:Larsen's human embryology 4th edn.jpg|90px]]
 
| '''Citation:''' Larsen's human embryology 4th ed. Schoenwolf, Gary C; Larsen, William J, (William James). Philadelphia, PA : Elsevier/Churchill Livingstone, c2009. (links available to UNSW students)
 
* [http://er.library.unsw.edu.au/er/cgi-bin/eraccess.cgi?url=http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06811-9&eid=4-u1.0-B978-0-443-06811-9..10015-6 Chapter 15 - Development of the Urogenital System]
 
|}
 
 
 
 
 
:'''Links:''' [[Embryology Textbooks]]
 
 
 
 
 
{{ANAT2341Lab8}}
 
 
 
{{Glossary}}
 
 
 
{{Footer}}
 

Latest revision as of 16:37, 8 November 2019

PRACTICAL CLASS PROGRAM:

  • Weekly Quiz + revision (10 minutes)
  • Completion of surveys (10 minutes)
  • Practical class activities (40 minutes)
  • Guest Lecture by A/Prof Stuart Fraser (45 minutes)
  • Practical Class Revision (15 minutes)


PRACTICAL CLASS ACTIVITIES (40 minutes):

  • Cell lineage activity
  • Investigate the chicken embryo skeletal preps


LEARNING OBJECTIVES:

  • Understanding organogenesis
  • Understanding the developmental paths of cell types/structures
  • Understand the developmental basis of human disease
  • Understanding skeletal development
  • Understanding blood cell development
  • Understanding research into blood cell development


Blood Cell Development - A/Prof Stuart Fraser

Biographical details

Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan. Back to Top

Stuart's main research interests focus upon the mechanisms controlling the formation of the blood, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.

References

Colonne CK, Yeo JH, McKenzie CV & Fraser ST. (2019). Identification and Analysis of Mouse Erythroid Progenitor Cells. Methods Mol. Biol. , 2029, 125-145. PMID: 31273739 DOI.

Yeo JH, Cosgriff MP & Fraser ST. (2018). Analyzing the Formation, Morphology, and Integrity of Erythroblastic Islands. Methods Mol. Biol. , 1698, 133-152. PMID: 29076088 DOI.

Yumine A, Fraser ST & Sugiyama D. (2017). Regulation of the embryonic erythropoietic niche: a future perspective. Blood Res , 52, 10-17. PMID: 28401096 DOI.

Ross SB, Fraser ST, Bagnall RD & Semsarian C. (2017). Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy. Stem Cell Res , 20, 76-79. PMID: 28395744 DOI.

Yeo JH, McAllan BM & Fraser ST. (2016). Scanning Electron Microscopy Reveals Two Distinct Classes of Erythroblastic Island Isolated from Adult Mammalian Bone Marrow. Microsc. Microanal. , 22, 368-78. PMID: 26898901 DOI.

Al-Drees MA, Yeo JH, Boumelhem BB, Antas VI, Brigden KW, Colonne CK & Fraser ST. (2015). Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int , 2015, 571893. PMID: 26113865 DOI.

Search PubMed: Fraser ST