Difference between revisions of "ANAT2341 Lab 8"

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==Skin Development and Regeneration==
 
  
  
 
== 1. QUIZ ==
 
== 1. QUIZ ==
  
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== 2. Guest Lecturer - Stuart Fraser ==
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| width=185px|[[File:Stuart_Fraser.jpg]]
  
== 2. Dr. Annemiek Beverdam (UNSW) - "Stem cell regulation in normal skin regeneration and in skin disease" ==
 
  
[[File:Annemiek Beverdam profile photo.jpeg]]
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| valign=top|'''Blood Cell Development'''
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<br><br>
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Biographical details
  
Dr. Annemiek Beverdam studies the genetic processes that govern development, homeostasis and regeneration of the skin in the mouse. Her research aims at understanding the genetic and molecular basis of developmental and human regenerative skin diseases such as skin cancer, which affects 2 out of 3 Australians in their life time. Her lab recently made the pivotal discoveries that Yes-associated protein (YAP) functions acts as a key molecular switch in epidermal stem/progenitor cell proliferation and differentiation [https://www.ncbi.nlm.nih.gov/pubmed/23190885] by driving β-Catenin Activation [https://www.ncbi.nlm.nih.gov/pubmed/27816394]. Dr. Beverdam currently investigates the developmental genetic context in which YAP functions to control skin stem/progenitor cells in normal and in disrupted skin biology. She employs genetically manipulated mouse models, human skin samples, advanced imaging technology such as confocal microscopy and whole mouse in vivo imaging, gene and protein expression analyses and whole genome approaches to address her research questions. Her research will open up exciting new avenues for translational research and the development of treatments for human regenerative skin disease such as skin cancer and eczema.
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Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan.
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'''References:'''
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Stuart's main research interests focus upon the mechanisms controlling the formation of the {{blood}}, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.
Akladios B., Mendoza-Reinoso V., Samuel MS., Hardeman E., Khosrotehrani K., Key B; Beverdam A (2016). ‘Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in the Mouse Skin in vivo’. Accepted for publication in The Journal of Investigative Dermatology.
 
  
Liang H*, Akladios B*, Canales CP*, Francis R, Hardeman EH, Beverdam A. CUBIC protocol visualizes protein expression at single cell resolution in whole mount skin preparations (2016). JoVE, accepted for publication doi:10.3791/54401.
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[https://moodle.telt.unsw.edu.au/pluginfile.php/3304045/mod_forum/attachment/2517784/Sally%202018.pdf Fraser Lecture Slides 2018]
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==References==
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{{#pmid:31273739}}
  
Corley SM, Canales C, Carmona-Mora P, Mendoza-Reinoso V, Beverdam A, Hardeman EH, Wilkins M, Palmer S. (2016). RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome. BMC Genomics, accepted for publication.
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{{#pmid:29076088}}
  
James G., Key B., Beverdam A. (2014). The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system. Brain Structure and Function. Volume 219, Issue 3, Page 861-874. Impact Factor: 7.8. (Link to PubMed)
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{{#pmid:28401096}}
  
James G., Foster SR., Key B., Beverdam A. (2013). The Expression Pattern of EVA1C, a Novel Slit Receptor, Is Consistent with an Axon Guidance Role in the Mouse Nervous System. PLoS One, Sep 9;8(9):e74115. doi: 10.1371/journal.pone.0074115. Impact Factor: 3.8. (Link to PubMed)
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{{#pmid:28395744}}
  
Beverdam A., Claxton C., Zhang., X., James G., Harvey KF, Key B. (2013). YAP controls stem/progenitor cell proliferation in the mouse postnatal epidermis. Journal of Investigative Dermatology, Impact factor 6.3. (Link to PubMed)
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{{#pmid:26898901}}
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{{#pmid:26113865}}
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Search PubMed: [https://www.ncbi.nlm.nih.gov/pubmed/?term=Fraser%20ST%5BAuthor%5D&cauthor=true&cauthor_uid=31273739 Fraser ST]

Latest revision as of 10:33, 16 July 2019


1. QUIZ

2. Guest Lecturer - Stuart Fraser

Stuart Fraser.jpg


Blood Cell Development



Biographical details

Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan. Back to Top

Stuart's main research interests focus upon the mechanisms controlling the formation of the blood, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.

Fraser Lecture Slides 2018

References

Colonne CK, Yeo JH, McKenzie CV & Fraser ST. (2019). Identification and Analysis of Mouse Erythroid Progenitor Cells. Methods Mol. Biol. , 2029, 125-145. PMID: 31273739 DOI.

Yeo JH, Cosgriff MP & Fraser ST. (2018). Analyzing the Formation, Morphology, and Integrity of Erythroblastic Islands. Methods Mol. Biol. , 1698, 133-152. PMID: 29076088 DOI.

Yumine A, Fraser ST & Sugiyama D. (2017). Regulation of the embryonic erythropoietic niche: a future perspective. Blood Res , 52, 10-17. PMID: 28401096 DOI.

Ross SB, Fraser ST, Bagnall RD & Semsarian C. (2017). Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy. Stem Cell Res , 20, 76-79. PMID: 28395744 DOI.

Yeo JH, McAllan BM & Fraser ST. (2016). Scanning Electron Microscopy Reveals Two Distinct Classes of Erythroblastic Island Isolated from Adult Mammalian Bone Marrow. Microsc. Microanal. , 22, 368-78. PMID: 26898901 DOI.

Al-Drees MA, Yeo JH, Boumelhem BB, Antas VI, Brigden KW, Colonne CK & Fraser ST. (2015). Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int , 2015, 571893. PMID: 26113865 DOI.

Search PubMed: Fraser ST