Difference between revisions of "ANAT2341 Lab 8"

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{{ANAT2341Lab8}}
 
==Urogenital Development==
 
This practical will introduce the topic of urogenital differentiation during development through a series of online resource pages.
 
  
'''Aim:''' This practical is an introduction to the earliest events in Sexual Differentiation.
 
  
'''Key Concepts:''' Intermediate mesoderm, primordial germ cells, renal development, bladder development, gonad, internal genitalia, external genitalia, ovary, testes, puberty, hormonal changes, gametogenesis, abnormalities.
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== 1. QUIZ ==
  
==Background==
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== 2. Guest Lecturer - Stuart Fraser ==
{|
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{|  
| [[File:Historic-testis.jpg|140px]]
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| width=185px|[[File:Stuart_Fraser.jpg]]
  
[[File:Historic-ovary.jpg|200px]]
 
  
'''Historic Gonad Images'''
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| valign=top|'''Blood Cell Development'''
| valign="top" | Two key systems, neural and reproductive, develop over an extended period from the early embryo to puberty and the emerging adult. The genital system is closely linked developmentally to the urinary system, often called the urogenital system. This practical will therefore cover early development of both system.
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<br><br>
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Biographical details
  
In understanding embryonic sexual development, think of a cascade of sequence dependent events that transform indifferent gonads, internal and external genitalia into distinct male and female structures.  
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Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan.
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Back to Top
  
The process begins with gonad differentiation, which itself is tied developmentally back at the initial event of fertilization and the presence of either a Y or X chromosome in the sperm.
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Stuart's main research interests focus upon the mechanisms controlling the formation of the {{blood}}, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.
  
The endpoint of development could be considered the post-puberty active reproductive system. Interestingly, recent research is pointing to a link between neural and reproductive systems in how male and female brains may differentially develop under the influence of sex hormones and perhaps even the sex chromosomes.
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[https://moodle.telt.unsw.edu.au/pluginfile.php/3304045/mod_forum/attachment/2517784/Sally%202018.pdf Fraser Lecture Slides 2018]
 
 
 
 
* There are 6 pages to work through in today's practical class, listed at the top and bottom of each page.
 
* Additional information sections are not part of the practical class content.
 
 
|}
 
|}
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==References==
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{{#pmid:31273739}}
  
==Genital Timeline==
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{{#pmid:29076088}}
''These are approximate timings and stages only.''
 
 
 
* [[Carnegie stage 11|24 days]] - intermediate mesoderm, pronephros primordium
 
* [[Carnegie stage 13|28 days]] - mesonephros and mesonephric duct
 
* [[Carnegie stage 15|35 days]] - uteric bud, metanephros, urogenital ridge
 
* [[Carnegie stage 17|42 days]] - cloacal divison, gonadal primordium (indifferent)
 
* [[Carnegie stage 19|49 days]] - paramesonephric duct, gonadal differentiation
 
* [[Carnegie stage 23|56 days]] - paramesonephric duct fusion (female)
 
* 100 days - primary follicles (ovary)
 
 
 
==Textbooks==
 
{|
 
|-
 
| [[File:Logo.png|80px]]
 
| {{Embryo citation}}
 
 
 
{{Renal Links}}
 
 
 
{{Genital Links}}
 
|-
 
| [[File:The Developing Human, 8th edn.jpg|80px]]
 
| Moore, K.L. &amp; Persuad, T.V.N. (2008). <i>The Developing Human: clinically oriented embryology</i> (8<sup>th</sup> ed.). Philadelphia: Saunders.
 
 
 
The following chapter links only work with a UNSW connection and can also be accessed through this  [http://searchfirst.library.unsw.edu.au/primo_library/libweb/action/search.do?vid=UNSW&amp;fn=search&amp;vl(freeText0)=UNSW_SFX14190000000048007 UNSW Library connection].
 
* [http://www.mdconsult.com/books/linkTo?type=bookPage&amp;isbn=978-1-4160-3706-4&amp;eid=4-u1.0-B978-1-4160-3706-4..50015-3 Chapter 12 - The Urogenital System]
 
|-
 
| [[File:Larsen's human embryology 4th edn.jpg|80px]]
 
| Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H. (2009). <i>Larsen’s Human Embryology</i>  (4<sup>th</sup> ed.). New York; Edinburgh: Churchill Livingstone.
 
 
 
The following chapter links only work with a UNSW connection and can also be accessed through this [http://searchfirst.library.unsw.edu.au/primo_library/libweb/action/search.do?vid=UNSW&fn=search&vl(freeText0)=UNSW_SFX14190000000047996 UNSW Library connection].
 
* [http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06811-9&eid=4-u1.0-B978-0-443-06811-9..10015-6 Chapter 15 - Development of the Urogenital System]
 
 
 
|}
 
  
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{{#pmid:28401096}}
  
{{ANAT2341Lab8}}
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{{#pmid:28395744}}
  
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{{#pmid:26898901}}
  
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{{#pmid:26113865}}
  
{{2015ANAT2341}}
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Search PubMed: [https://www.ncbi.nlm.nih.gov/pubmed/?term=Fraser%20ST%5BAuthor%5D&cauthor=true&cauthor_uid=31273739 Fraser ST]

Latest revision as of 10:33, 16 July 2019


1. QUIZ

2. Guest Lecturer - Stuart Fraser

Stuart Fraser.jpg


Blood Cell Development



Biographical details

Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan. Back to Top

Stuart's main research interests focus upon the mechanisms controlling the formation of the blood, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.

Fraser Lecture Slides 2018

References

Colonne CK, Yeo JH, McKenzie CV & Fraser ST. (2019). Identification and Analysis of Mouse Erythroid Progenitor Cells. Methods Mol. Biol. , 2029, 125-145. PMID: 31273739 DOI.

Yeo JH, Cosgriff MP & Fraser ST. (2018). Analyzing the Formation, Morphology, and Integrity of Erythroblastic Islands. Methods Mol. Biol. , 1698, 133-152. PMID: 29076088 DOI.

Yumine A, Fraser ST & Sugiyama D. (2017). Regulation of the embryonic erythropoietic niche: a future perspective. Blood Res , 52, 10-17. PMID: 28401096 DOI.

Ross SB, Fraser ST, Bagnall RD & Semsarian C. (2017). Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy. Stem Cell Res , 20, 76-79. PMID: 28395744 DOI.

Yeo JH, McAllan BM & Fraser ST. (2016). Scanning Electron Microscopy Reveals Two Distinct Classes of Erythroblastic Island Isolated from Adult Mammalian Bone Marrow. Microsc. Microanal. , 22, 368-78. PMID: 26898901 DOI.

Al-Drees MA, Yeo JH, Boumelhem BB, Antas VI, Brigden KW, Colonne CK & Fraser ST. (2015). Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int , 2015, 571893. PMID: 26113865 DOI.

Search PubMed: Fraser ST