Difference between revisions of "ANAT2341 Lab 8"

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==Organogenesis Lab==
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== 1. QUIZ ==
 
== 1. QUIZ ==
  
== 2. Organogenesis Lab ==
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== 2. Guest Lecturer - Sally Dunwoodie ==
In this lab you will dissect fertile chicken eggs and study fixed mouse embryos up to mid-gestation using dissection microscopes. You will name the embryonic anatomical structures, and describe what these will give rise to.
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{|
 
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| width=185px|[[File:Sally.jpeg|180px]]
[[Media:ANAT2341_-_INTRODUCTION_TO_THE_CHICK_EMBRYO.pdf|Organogensis Lab Manual]]
 
 
 
[[File:Chicken_Embryo_Hamburger_stages.jpg|600px|link=Hamburger Hamilton Stages]]
 
 
 
''These are the Hamburger stages of chicken development''
 
 
 
 
 
See also the [https://www.jove.com/video/306/windowing-chicken-eggs-for-developmental-studies JoVE article on chicken egg preparation]: <pubmed>18989413</pubmed>
 
 
 
 
 
 
 
More about chicken embryogenesis: [[Chicken Development]] | [[Hamburger Hamilton Stages]]
 
 
 
  
<gallery>
 
File:HHstage1-4.jpg|stage 1-4
 
File:HHstage5-10.jpg|stages 5-10
 
File:HHstage11-14.jpg|stages 11-14
 
File:HHstage15-18.jpg|stages 15-18
 
File:HHstage19-21.jpg|stages 19-21
 
File:HHstage22-25.jpg|stages 22-25
 
File:HHstage26-28.jpg|stages 26-28
 
File:HHstage29-32.jpg|stage 29-32
 
</gallery>
 
  
[[File:Mouse_vs_Human_embryogenesis.jpg]]
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| valign=top|'''Somitogenesis and Congenital Vertebral Malformation'''
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<br><br>
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Professor Sally Dunwoodie is an internationally renowned biomedical researcher at the Victor Chang Cardiac Research Institute. She has dedicated her life’s work to understanding how babies develop and to finding out why some 3-6% have birth defects. Some 4.9 million babies are born with a serious birth defect around the globe every year.
  
''This figure compares the human and mouse developmental stages''
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Professor Dunwoodie established and leads the Chain Reaction Program in Congenital Heart Disease, the largest Australian genome sequencing initiative in congenital heart disease. The program is discovering the genetic causes of heart defects family by family, with the promise that genetic diagnosis of birth defects will become a routine part of clinical practice.
  
More about Mouse embryogenesis: [[Mouse Timeline Detailed]]
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Professor Dunwoodie is also a world leader in identifying causes of vertebral defects, having discovered six of the seven genes known to cause such defects.
  
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Professor Dunwoodie’s discoveries have already changed clinical practices and have led to genetic diagnostic tests being available worldwide. In 2017 Professor Dunwoodie’s team revealed a double breakthrough that has the potential to prevent some cases of recurrent miscarriage and multiple types of birth defects.
  
{{Chicken}}
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They discovered that deficiency in NAD, a vital molecule that is required for hundreds of activities in all cells, causes recurrent miscarriage and multiple types of birth defects in humans and mice. These defects were completely prevented with supplementation of niacin (vitamin B3) during pregnancy in mice. These discoveries from the Victor Chang Cardiac Research Institute are believed to be amongst Australia’s greatest ever in pregnancy research.
  
===External Links===
 
{{External Links}}
 
  
* JOVE - [http://www.jove.com/science-education/5153/an-introduction-to-the-chick-gallus-gallus-domesticus An Introduction to the Chicken]
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[https://www.victorchang.edu.au/heart-research/embryology VCCRI - Embryology]
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|}
  
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{{2017ANAT2341 footer}}
 
{{2017ANAT2341 footer}}

Revision as of 11:46, 19 July 2018


1. QUIZ

2. Guest Lecturer - Sally Dunwoodie

180px


Somitogenesis and Congenital Vertebral Malformation



Professor Sally Dunwoodie is an internationally renowned biomedical researcher at the Victor Chang Cardiac Research Institute. She has dedicated her life’s work to understanding how babies develop and to finding out why some 3-6% have birth defects. Some 4.9 million babies are born with a serious birth defect around the globe every year.

Professor Dunwoodie established and leads the Chain Reaction Program in Congenital Heart Disease, the largest Australian genome sequencing initiative in congenital heart disease. The program is discovering the genetic causes of heart defects family by family, with the promise that genetic diagnosis of birth defects will become a routine part of clinical practice.

Professor Dunwoodie is also a world leader in identifying causes of vertebral defects, having discovered six of the seven genes known to cause such defects.

Professor Dunwoodie’s discoveries have already changed clinical practices and have led to genetic diagnostic tests being available worldwide. In 2017 Professor Dunwoodie’s team revealed a double breakthrough that has the potential to prevent some cases of recurrent miscarriage and multiple types of birth defects.

They discovered that deficiency in NAD, a vital molecule that is required for hundreds of activities in all cells, causes recurrent miscarriage and multiple types of birth defects in humans and mice. These defects were completely prevented with supplementation of niacin (vitamin B3) during pregnancy in mice. These discoveries from the Victor Chang Cardiac Research Institute are believed to be amongst Australia’s greatest ever in pregnancy research.


VCCRI - Embryology


 2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3

Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 Genetic Disorders | 10 Melanocytes | 11 Stem Cells | 12 Group

Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision

 Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum