ANAT2341 Lab 6

2. Guest Lecturer - Dr Tenille Luker - Sibbritt

Dr Tenille Luker - Sibbritt

Dr Tennille Sibbritt is researcher at the Children's Medical Research Institute (CMRI) at Westmead. She graduated with a PhD in RNA Biology in 2015. In 2016, she started working in the Embryology Unit at the CMRI, where she is building a gene regulatory network for head development using mouse embryos. A gene regulatory network is a collection of molecular species that interact with each other and other species to regulate gene expression. They play a central role in the morphogenesis, regionalisation, and patterning of the brain and craniofacial structures, which rely on the function of various transcription factors; these transcription factors constitute the central nodes of these gene regulatory networks. Tennille’s research involves the use of high-throughput sequencing technologies and CRISPR-Cas9 genomic editing in combination with fast-tracked mouse chimera analysis.

References

Recent book chapters and articles relating to craniofacial development from the Embryology Unit include:

P. P. Tam, N. Fossat, E. Wilkie, D. A. Loebel, C. K. Ip, M. Ramialison, Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network, Curr. Top. Dev. Biol., 117 (2016) 497-521.

N. Fossat, C.K. Ip, V. J. Jones, J.B. Studdert, P. L. Khoo, S. L. Lewis, M. Power, K. Tourle, D. A. Loebel, K. M. Kwan, R. R. Behringer, P. P. Tam N., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo, Development, 142 (2015) 2069-2079.

N. Fossat, V. Jones, P. L. Khoo, D. Bogani, A. Hardy, K. Steiner, M. Mukhopadhyay, H. Westphal, P. M. Nolan, R. Arkell, P. P. Tam, Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo, Development, 138 (2011) 667-676.