ANAT2341 Lab 6: Difference between revisions
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Dr Walters’ research involves using customized genetic mouse models in combination with clinical samples and trials to dissect out the fundamental mechanisms regulating female reproduction and polycystic ovary syndrome (PCOS). In particular, her research has focused on understanding the role androgens play in regulating female fertility and PCOS. Findings from this research will identify therapeutic targets for improved treatment of female infertility and the wide range of health issues associated with PCOS, including obesity, insulin resistance, type 2 diabetes and cardiovascular risk. | Dr Walters’ research involves using customized genetic mouse models in combination with clinical samples and trials to dissect out the fundamental mechanisms regulating female reproduction and polycystic ovary syndrome (PCOS). In particular, her research has focused on understanding the role androgens play in regulating female fertility and PCOS. Findings from this research will identify therapeutic targets for improved treatment of female infertility and the wide range of health issues associated with PCOS, including obesity, insulin resistance, type 2 diabetes and cardiovascular risk. | ||
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[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf|'''Walters Lecture Slides''']] | |||
==An Introduction to Polycystic Ovary Syndrome (PCOS)== | ==An Introduction to Polycystic Ovary Syndrome (PCOS)== |
Revision as of 13:37, 3 September 2018
1. QUIZ
2. Guest Lecturer - Dr Kirsty Walters
An Introduction to Polycystic Ovary Syndrome (PCOS)
<html5media width="600" height="400">https://www.youtube.com/embed/NhyYZCBq5A8</html5media>
Polycystic Ovary Syndrome Mouse Model
Caldwell ASL, Edwards MC, Desai R, Jimenez M, Gilchrist RB, Handelsman DJ & Walters KA. (2017). Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome. Proc. Natl. Acad. Sci. U.S.A. , 114, E3334-E3343. PMID: 28320971 DOI.
References
Walters KA, Edwards MC, Tesic D, Caldwell ASL, Jimenez M, Smith JT & Handelsman DJ. (2018). The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis. Neuroendocrinology , 106, 389-400. PMID: 29635226 DOI.
Leloup-Hatey J, Baloche S & Jolivet-Jaudet G. (1988). [Changes in corticosterone and aldosterone concentrations in various tissues of Xenopus laevis tadpoles during the metamorphosis]. C. R. Seances Soc. Biol. Fil. , 182, 354-60. PMID: 2977958 1
Bertoldo MJ, Walters KA, Ledger WL, Gilchrist RB, Mermillod P & Locatelli Y. (2018). In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies. Reprod. Biomed. Online , , . PMID: 29503209 DOI.
Upton DH, Walters KA, McTavish KJ, Holt J, Handelsman DJ & Allan CM. (2018). Reproductive failure in mice expressing transgenic follicle-stimulating hormone is not caused by loss of oocyte quality. Biol. Reprod. , 98, 491-500. PMID: 29365049 DOI.
Walters KA & Handelsman DJ. (2017). Role of androgens in the ovary. Mol. Cell. Endocrinol. , , . PMID: 28687450 DOI.
Search PubMed: Walters KA