ANAT2341 Lab 2
|Embryology - 10 Aug 2020 Expand to Translate|
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|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
2. Guest Lecturer - A/Prof Robert Gilchrist
A/Prof Robert Gilchrist
|The Reproductive Technology Revolution
- "The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades and many of the long standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP inhibiting the hydrolysis of intra-oocyte cAMP and that the preovulatory gonadotrophin surge reverses these processes. The gonadotrophin surge also leads to a transient spike in cAMP in the somatic compartment of the follicle; research over the past 2 decades has conclusively demonstrated that this surge in cAMP is important for the subsequent developmental capacity of the oocyte. This is important, as oocyte in vitro maturation (IVM) systems practiced clinically do not recapitulate this cAMP surge in vitro, possibly accounting for the lower efficiency of IVM compared to clinical IVF. This review focuses in particular on this latter aspect - the role of cAMP/cGMP in the regulation of oocyte quality. We conclude that clinical practice of IVM should reflect this new understanding of the role of cyclic nucleotides, thereby creating a new generation of ART and fertility treatment options."
- Gilchrist RB, Luciano AM, Richani D, Zeng HT, Wang X, Vos MD, Sugimura S, Smitz J, Richard FJ & Thompson JG. (2016). Oocyte maturation and quality: role of cyclic nucleotides. Reproduction , 152, R143-57. PMID: 27422885 DOI.
- Robertson DM, Gilchrist RB, Ledger WL & Baerwald A. (2016). Random start or emergency IVF/in vitro maturation: a new rapid approach to fertility preservation. Womens Health (Lond) , 12, 339-49. PMID: 27248769 DOI.
- Russell DL, Gilchrist RB, Brown HM & Thompson JG. (2016). Bidirectional communication between cumulus cells and the oocyte: Old hands and new players?. Theriogenology , 86, 62-8. PMID: 27160446 DOI.