ANAT2341 Lab 2: Difference between revisions
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== 1. QUIZ == | == 1. QUIZ == | ||
== 2. Guest Lecturer - | ==2. Guest Lecturer - A/Prof Robert Gilchrist == | ||
[[File:Oocyte BMP15 and GDF9 effects.jpg|thumb|Oocyte BMP15 and GDF9 effects PMID 25058588]] | |||
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| [[File:Rob Gilchrist.jpg|left|150px|alt=Associate Professor Robert Gilchrist|link=https://research.unsw.edu.au/people/associate-professor-robert-bruce-gilchrist]] | |||
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A/Prof Robert Gilchrist | |||
| '''The Reproductive Technology Revolution''' | |||
<br><br> | |||
Dr Gilchristis head of the Oocyte Biology Research Unit (UNSW) his primary research interests are in the regulation of mammalian oocyte development and maturation, and the development of novel oocyte maturation techniques for infertility treatment. | |||
[[Media:2017 Anatomy IVF and embryology lab.pdf|Lecture Slides]] | |||
<br><br> | |||
: | Links: [https://research.unsw.edu.au/people/associate-professor-robert-bruce-gilchrist UNSW Research Gateway] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Gilchrist+R%5BAuthor%5D PubMed] | ||
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=== | ===Recent Articles=== | ||
{{ | {{#pmid:27422885|PMID27422885}} | ||
:"The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades and many of the long standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP inhibiting the hydrolysis of intra-oocyte cAMP and that the preovulatory gonadotrophin surge reverses these processes. The gonadotrophin surge also leads to a transient spike in cAMP in the somatic compartment of the follicle; research over the past 2 decades has conclusively demonstrated that this surge in cAMP is important for the subsequent developmental capacity of the oocyte. This is important, as oocyte in vitro maturation (IVM) systems practiced clinically do not recapitulate this cAMP surge in vitro, possibly accounting for the lower efficiency of IVM compared to clinical IVF. This review focuses in particular on this latter aspect - the role of cAMP/cGMP in the regulation of oocyte quality. We conclude that clinical practice of IVM should reflect this new understanding of the role of cyclic nucleotides, thereby creating a new generation of ART and fertility treatment options." | |||
{{#pmid:27248769|PMID27248769}} | |||
{{#pmid:27160446|PMID27160446}} | |||
{{ | |||
==3. Group Project== | |||
* Progress reports from groups. | |||
* [[Student_Page#Upload_Image_Tutorial|Image upload tutorial]] | |||
* Any issues? | |||
<br> | <br> | ||
{{2017ANAT2341 footer}} | {{2017ANAT2341 footer}} | ||
Revision as of 13:17, 19 July 2018
Embryology - 25 Apr 2024    Expand to Translate
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1. QUIZ
2. Guest Lecturer - A/Prof Robert Gilchrist
 A/Prof Robert Gilchrist |
The Reproductive Technology Revolution
Links: UNSW Research Gateway | PubMed |
Recent Articles
- "The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades and many of the long standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP inhibiting the hydrolysis of intra-oocyte cAMP and that the preovulatory gonadotrophin surge reverses these processes. The gonadotrophin surge also leads to a transient spike in cAMP in the somatic compartment of the follicle; research over the past 2 decades has conclusively demonstrated that this surge in cAMP is important for the subsequent developmental capacity of the oocyte. This is important, as oocyte in vitro maturation (IVM) systems practiced clinically do not recapitulate this cAMP surge in vitro, possibly accounting for the lower efficiency of IVM compared to clinical IVF. This review focuses in particular on this latter aspect - the role of cAMP/cGMP in the regulation of oocyte quality. We conclude that clinical practice of IVM should reflect this new understanding of the role of cyclic nucleotides, thereby creating a new generation of ART and fertility treatment options."
3. Group Project
- Progress reports from groups.
- Image upload tutorial
- Any issues?
- ↑ Gilchrist RB, Luciano AM, Richani D, Zeng HT, Wang X, Vos MD, Sugimura S, Smitz J, Richard FJ & Thompson JG. (2016). Oocyte maturation and quality: role of cyclic nucleotides. Reproduction , 152, R143-57. PMID: 27422885 DOI.
- ↑ Robertson DM, Gilchrist RB, Ledger WL & Baerwald A. (2016). Random start or emergency IVF/in vitro maturation: a new rapid approach to fertility preservation. Womens Health (Lond) , 12, 339-49. PMID: 27248769 DOI.
- ↑ Russell DL, Gilchrist RB, Brown HM & Thompson JG. (2016). Bidirectional communication between cumulus cells and the oocyte: Old hands and new players?. Theriogenology , 86, 62-8. PMID: 27160446 DOI.
