2018 Group Project 5
From Embryology
| Projects 2018: 1 Adrenal Medulla | 3 Melanocytes | 4 Cardiac | 5 Dorsal Root Ganglion |
Project Pages are currently being updated (notice removed when completed)
Dorsal Root Ganglion
Introduction
Dorsal Root Ganglion is a cluster of neurone found in the dorsal root of the spinal nerve. The cells found in the ganglion develops from the neural crest migration at about 4 weeks post-conception (pc).
History
Embryonic Origins
Developmental Process
Neural Crest Migration in Formation of the DRG
Trunk neural crest cells migrate via a ventromedial pathway on the neural tube during the fourth week of development. Depending on where these cells cease their migration will determine the structure into which they develop. The neural crest cells that will divide to form the dorsal root ganglion cease migration once they have reached the area of the perisomitic vessel next to the neural tube. [1].
Adult Function
Tissue / Organ Structure
Molecular Mechanisms / Factors / Genes
CXCR4 Chemokine Receptor
Abnormalities / Abnormal Development
Animal Models
Zebrafish Model
Current Research (Labs)
Link on current research for DRG [2]
Glossary
Reference List
- ↑ 1.0 1.1 Kasemeier-Kulesa JC, Kulesa PM & Lefcort F. (2005). Imaging neural crest cell dynamics during formation of dorsal root ganglia and sympathetic ganglia. Development , 132, 235-45. PMID: 15590743 DOI.
- ↑ 2.0 2.1 Sapunar D, Kostic S, Banozic A & Puljak L. (2012). Dorsal root ganglion - a potential new therapeutic target for neuropathic pain. J Pain Res , 5, 31-8. PMID: 22375099 DOI.
- ↑ George L, Dunkel H, Hunnicutt BJ, Filla M, Little C, Lansford R & Lefcort F. (2016). In vivo time-lapse imaging reveals extensive neural crest and endothelial cell interactions during neural crest migration and formation of the dorsal root and sympathetic ganglia. Dev. Biol. , 413, 70-85. PMID: 26988118 DOI.
- ↑ George L, Kasemeier-Kulesa J, Nelson BR, Koyano-Nakagawa N & Lefcort F. (2010). Patterned assembly and neurogenesis in the chick dorsal root ganglion. J. Comp. Neurol. , 518, 405-22. PMID: 20017208 DOI.
- ↑ Ogawa R, Fujita K & Ito K. (2017). Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells. Biol Open , 6, 602-618. PMID: 28373172 DOI.
- ↑ Kasemeier-Kulesa JC, McLennan R, Romine MH, Kulesa PM & Lefcort F. (2010). CXCR4 controls ventral migration of sympathetic precursor cells. J. Neurosci. , 30, 13078-88. PMID: 20881125 DOI.
