2017 Group Project 5: Difference between revisions

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==Developmental timeline==
===Developmental timeline===


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Revision as of 16:13, 7 September 2017

2017 Student Projects 
Student Projects: 1 Cerebral Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum
Student Page - here is the sample page I demonstrated with in the first labs.I remind all students that you have your own Group Forum on Moodle for your discussions, it is only accessible by members of your group.
Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student

Lungs

An introduction to the lungs...

On this page, we will be exploring the development of the lungs through the stages of embryonic growth.


Developmental origin overview

The Respiratory Zone

The Terminal Bronchioles

Alveolar ducts

Alveoli

The Conducting Zone

The Lung Development Stages

Stage
Description
Embryonic (weeks 4-5)
About
Pseudoglandular (weeks 5-17)
About
Canalicular (weeks 16-25)
About
Saccular (weeks 24-40)
About
Alveolar (week 36-8 years)
About

Developmental timeline

Year
Historical Development
1600s
Marcello Malpighi (1628-1694) pioneered the use of the first microscope which paved the way for many discoveries in his fields of embryology and botany. One of his many significant discoveries included identifying pulmonary capillaries in frogs; published in 1661 in De pulonibis [1]
1810-1820s
Christian Pander, Karl Ernst von Baer, and Heinrich Rathke were among the first to use a new wave of technology in embryology; involving the use of new staining techniques and improved microscopy. Their findings together identified the presence of primary germ layers (ectoderm, endoderm and mesoderm) and the development of early organs. [2]
1817
Christian Pander furthered his research by studying chick embryos. Through this, he determined that the germ layers all worked together to form organs that gave significant evidence towards the notion of epigenesis. [3]
10
blah
11
23 - 26
12
26 - 30
13
28 - 32

Developmental signalling processes

Chemicals involved in the development of lungs. Growth factors that contribute to branching of lungs - SHH and fibroblast growth factor as well as any other hormones or factors that are relevant to lung development

The conducting system

Branching of lungs Different types of branching - domain branching, planar bifurcation, trifurcation, orthogonal bifurcation.

Alveolus: the functional unit

How the alveoli work. Cell types Maturation and development Lungs become fully developed within the mother, however they do not function until birth.

Current understandings and areas of research

include any relevant articles

Review and research articles

Movies

Animal models

Abnormal development

Premature Birth

Lobar Emphysema

Congenital diaphragmatic hernia

azygos lobe

meconium aspiration syndrome

newborn respiratory distress syndrome

surfactant metabolism

bronchopulmonary dysplasia

lung agenesis

cystic fibrosis

CHAOS (Congenital High Airway Obstruction Syndrome)

CPAM (Congenital Pulmonary Airway Malformation)

Future questions

Glossary

References

  1. Young, J. (1929). Malpighi’s “De Pulmonibus.” Proceedings of the Royal Society of Medicine, 23(1), 1–11.
  2. Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000. Comparative Embryology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9974/
  3. Gilbert SF. Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates; 2000. Comparative Embryology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9974/