2017 Group Project 4

From Embryology
2017 Student Projects 
Student Projects: 1 Cerebral Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum
Student Page - here is the sample page I demonstrated with in the first labs.I remind all students that you have your own Group Forum on Moodle for your discussions, it is only accessible by members of your group.
Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student

Eye Development

Introduction to the eye

The eye is a complex structure which allows a variety of species to intake and process visual information from the world around us.

In humans the wall of the eye has 3 basic layers: - An outer fibrous layer containing the posterior sclera and anterior cornea. The sclera --- - A vascular middle layer containing the choroid - An inner receptive layer containing the retina

Anterior structure

ref: https://ap01-a.alma.exlibrisgroup.com/view/uresolver/61UNSW_INST/openurl?ctx_enc=info:ofi/enc:UTF-8&ctx_id=10_1&ctx_tim=2017-09-07T14%3A11%3A09IST&ctx_ver=Z39.88-2004&url_ctx_fmt=info:ofi/fmt:kev:mtx:ctx&url_ver=Z39.88-2004&rfr_id=info:sid/primo.exlibrisgroup.com-scopus&req_id=&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.atitle=Anatomy%20of%20the%20eye&rft.jtitle=&rft.btitle=Handbook%20of%20Visual%20Display%20Technology&rft.aulast=Garhart&rft.auinit=C&rft.auinit1=&rft.auinitm=&rft.ausuffix=&rft.au=Garhart,%20C.&rft.aucorp=&rft.date=20120101&rft.volume=1&rft.issue=&rft.part=&rft.quarter=&rft.ssn=&rft.spage=73&rft.epage=82&rft.pages=73-82&rft.artnum=&rft.issn=&rft.eissn=&rft.isbn=9783540795674&rft.sici=&rft.coden=&rft_id=info:doi/10.1007/978-3-540-79567-4_2.1.1&rft.object_id=&rft.eisbn=&rft.edition=&rft.pub=Springer%20Berlin%20Heidelberg&rft.place=&rft.series=&rft.stitle=&rft.bici=&rft_id=info:bibcode/&rft_id=info:hdl/&rft_id=info:lccn/&rft_id=info:oclcnum/&rft_id=info:pmid/&rft_id=info:eric/((addata/eric}}&rft_dat=%3Cscopus%3E2-s2.0-84923867273%3C/scopus%3E,language=eng,view=UNSWS&svc_dat=single_service&env_type=test

Timeline of Eye Development

Development of the eye components

The eyes are derived from four sources:

  • The neuroectoderm of the forebrain forms
    • Retina
    • Posterior layers of the iris
    • The optic nerve.
  • The surface ectoderm of the head forms
    • The lens of the eye
    • The corneal epithelium.
  • The mesoderm between the neuroectoderm and the surface ectoderm forms
    • The fibrous and vascular coats of the eye
  • The neural crest cells forms
    • Choroid
    • Sclera
    • Corneal endothelium

INSERT PICTURE The eye starts to develop at 22 days. The optic grooves (sulci) appears in the neural folds at the cranial end of the embryo. When the neural fold fuse to form the forebrain, the optic grooves will form optic vesicles. The optic vesicles are continuous cavities from the cavity of the forebrain and project from the wall of the forebrain and into the mesenchyme. The optic vesicles will grow and the optic stalks will form to keep the connection between the optic vesicles and the forebrain. The optic vesicles will at some point come in contact with the surface ectoderm and at the same time, the surface ectoderm near the optic vesicles will thicken and form the lens placodes. The lens placodes will sink into the surface ectoderm and form lens pits. The edges of the lens pits will travel towards each other and fuse to form round lens vesicles, which will later lose connection with the surface ectoderm. The optic vesicles do also keep developing - they will form double-walled optic cups which are connected to the brain by the optic stalk. The optic cups will form the retina and the optic stalk will form the optic nerve. The optic cups will fold inwards around the lens while the lens vesicles have grown inwards so they have fully lost their connection with the surface ectoderm, which locates them in the cavities of the optic cups. The retinal fissures (linear grooves) will develop and cover the ventral surface of the optic cups and down to the optic stalk. The retinal fissures contain vascular mesenchyme and hyaloid blood vessels will develop here. The hyaloid artery supplies the structures in the eye with blood and the hyaloid vein will return the blood from these structures.




Optic Nerve


The axons of the ganglion cells of the neural retina will grow in the wall of the optic nerve. The cavity in the optic nerve will start disappearing, and instead, the axons of the ganglion cells will form the optic nerve.

Ciliary Body






Aquous Chambers




Choroid and Sclera





Lacrimal Glands


Extraocular muscles


<pubmed>26410132</pubmed> <pubmed>23071378</pubmed>

Common Abnormalities

We could talk briefly in this sections about the causes of short/long-sightedness and common causes of blindness at a developmental level - z3416557

Further Research

5117343 In the news, media, websites starting point: Macular Research: https://www.cera.org.au/research/macular-research/ > Bionic Eye - https://theconversation.com/artificial-vision-what-people-with-bionic-eyes-see-79758 Corneal Research: https://www.cera.org.au/research/corneal-research/ > Stem cells, corneal transplant Cellular Reprogramming: https://www.cera.org.au/cellular-reprogramming/ Glaucoma Research: https://www.cera.org.au/research/glaucoma-research/



  1. <pubmed>23528534</pubmed>

Recent papers

Mark Hill (talk) 10:15, 14 August 2017 (AEST) OK Group 4 below are some starting places.

<pubmed limit=5>Eye+Development</pubmed>

Here is a few papers talking about eye development

z5177670 - Eye Development and Retinogenesis (NCBI): NCBI

z5177670 - <pubmed>1100417</pubmed>

z5177670 - <pubmed>10627820</pubmed>

z5075309 - <pubmed>26956898</pubmed>

External links

Vision Links: vision | lens | retina | placode | extraocular muscle | cornea | eyelid | lacrima gland | vision abnormalities | Student project 1 | Student project 2 | Category:Vision | sensory
Historic Vision 
Historic Embryology: 1906 Eye Embryology | 1907 Development Atlas | 1912 Eye Development | 1912 Nasolacrimal Duct | 1917 Extraocular Muscle | 1918 Grays Anatomy | 1921 Eye Development | 1922 Optic Primordia | 1925 Eyeball and optic nerve | 1925 Iris | 1927 Oculomotor | 1928 Human Retina | 1928 Retina | 1928 Hyaloid Canal | Historic Disclaimer

PubMed Searches: Eye Development | Vision Development

BMC Dev Biol Search: Eye Development