2017 Group Project 4

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Eye Development

Introduction to the eye

We could give a description of the adult anatomy of the eye in this section - happy to take this as we've just covered this section in anatomy! - z3416557 Perfect! This is your section then! :-)

Timeline of Eye Development

Development and function of components in the eye

The eyes are derived from four sources.

  • The neuroectoderm of the forebrain will differentiate into the retina, the posterior layers of the iris and the optic nerve.
  • The surface ectoderm will form the lens of the eye and the corneal epithelium.
  • The mesoderm between the neuroectoderm and the surface ectoderm will form the fibrous and vascular coats of the eye
  • The neural crest cells will migrate into the mesenchyme and differentiate into the choroid, sclera, and corneal endothelium.


The eye starts to develop at 22 days. The optic grooves (sulci) appears in the neural folds at the cranial end of the embryo. When the neural fold fuse to form the forebrain, the optic grooves will form optic vesicles. The optic vesicles are continuous cavities from the cavity of the forebrain and project from the wall of the forebrain and into the mesenchyme. The optic vesicles will grow which will make the optic stalks form to keep the connection with the forebrain. Soon the optic vesicles will come in contact with the surface ectoderm. The surface ectoderm near the optic vesicles will thicken and form the lens placodes, which will later form the lenses. The lens placodes will sink into the surface ectoderm and form lens pits. The edges of the lens pits will travel towards each other and fuse to form round lens vesicles, which will lose connection with the surface ectoderm.


Optic Nerve

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Lens, ciliary body, iris

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Cornea

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Chambers of the eye and humors

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Sclera, choroid

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Eyelids and associated glands

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Extraocular muscles

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Retina

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<pubmed>26410132</pubmed> <pubmed>23071378</pubmed>

Common Abnormalities

We could talk briefly in this sections about the causes of short/long-sightedness and common causes of blindness at a developmental level - z3416557

Further Research

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Glossary

References


Recent papers

Mark Hill (talk) 10:15, 14 August 2017 (AEST) OK Group 4 below are some starting places.

<pubmed limit=5>Eye+Development</pubmed>

Here is a few papers talking about eye development

z5177670 - Eye Development and Retinogenesis (NCBI): NCBI

z5177670 - <pubmed>1100417</pubmed>

z5177670 - <pubmed>10627820</pubmed>

z5075309 - <pubmed>26956898</pubmed>

External links

Vision Links: vision | lens | retina | placode | extraocular muscle | cornea | eyelid | lacrima gland | vision abnormalities | Student project 1 | Student project 2 | Category:Vision | sensory
Historic Embryology - Vision 
Historic Embryology: 1906 Eye Embryology | 1907 Development Atlas | 1912 Eye Development | 1912 Nasolacrimal Duct | 1917 Extraocular Muscle | 1918 Grays Anatomy | 1921 Eye Development | 1922 Optic Primordia | 1925 Eyeball and optic nerve | 1925 Iris | 1927 Oculomotor | 1928 Human Retina | 1928 Retina | 1928 Hyaloid Canal | Historic Disclaimer

PubMed Searches: Eye Development | Vision Development

BMC Dev Biol Search: Eye Development