2017 Group Project 1: Difference between revisions

From Embryology
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•overmigration;Cobblestone (Type II) lissencephaly
•overmigration;Cobblestone (Type II) lissencephaly
Fragile X-Syndrome
Microlissencephaly
====Kallmann Syndrome====


===Disorders due to abnormal cortical maturation and organization/folding===
===Disorders due to abnormal cortical maturation and organization/folding===
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•destructive lesions.
•destructive lesions.


===Disorders due to abnormal Integrity of the Pial Surface===
====Muscle-Eye-Brain Disease====
====Walker-Warburg====
https://www.youtube.com/watch?v=luXDQrmMoUU
https://www.youtube.com/watch?v=luXDQrmMoUU


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<ref>Mahfouz, M. (2015). Imaging of cortical formation disorders - DRE 4 - Prof. Dr Mamdouh Mahfouz. [video] Available at: https://www.youtube.com/watch?v=l_nTggR7LTE [Accessed 23 Sep. 2017].</ref>
<ref>Mahfouz, M. (2015). Imaging of cortical formation disorders - DRE 4 - Prof. Dr Mamdouh Mahfouz. [video] Available at: https://www.youtube.com/watch?v=l_nTggR7LTE [Accessed 23 Sep. 2017].</ref>


====Corpus Callosum Agenesis====
===Corpus Callosum Agenesis===


<html5media height="400" width="500">https://www.youtube.com/watch?v=7zOa3LLrHKc</html5media>
<html5media height="400" width="500">https://www.youtube.com/watch?v=7zOa3LLrHKc</html5media>
<ref>Ezzo - Izzo, D. (2007). How the Body Works : The Corpus Callosum. [video] Available at: https://www.youtube.com/watch?v=7zOa3LLrHKc [Accessed 23 Sep. 2017].</ref>
<ref>Ezzo - Izzo, D. (2007). How the Body Works : The Corpus Callosum. [video] Available at: https://www.youtube.com/watch?v=7zOa3LLrHKc [Accessed 23 Sep. 2017].</ref>


====Fetal Alcohol Spectrum Disorder (FASD)====
===Fetal Alcohol Spectrum Disorder (FASD)===


====Fragile X-Syndrome====
===Rett Syndrome===
 
 
====Kallmann Syndrome====
 
====Microlissencephaly====
 
====Muscle-Eye-Brain Disease====
 
====Rett Syndrome====
 
====Walker-Warburg====


==Group Discussion Area (temporary heading)==
==Group Discussion Area (temporary heading)==

Revision as of 23:16, 23 September 2017

2017 Student Projects 
Student Projects: 1 Cerebral Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum
Student Page - here is the sample page I demonstrated with in the first labs.I remind all students that you have your own Group Forum on Moodle for your discussions, it is only accessible by members of your group.
Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student

Cerebral Cortex

Stage 22 image 217.jpg

Mark Hill (talk) 15:59, 14 September 2017 (AEST) Feedback

  • lots of sub-headings, but no actual text.
  • no defined structure to the sequence of sub-headings.
  • no research images related to what is an extensively researched topic.
  • historic background of key research findings, put our understanding today in perspective.
  • Lon list of abnormalities, with no description.

Introduction

( Susannah )

What is it?

For concept: https://www.youtube.com/watch?v=dNngOlsLuGI

You might find this helpful (although you need to request copyright permission):

"Difference Between Cerebrum and Cerebral Cortex." DifferenceBetween.Com. August 7, 2012. < http://www.differencebetween.com/difference-between-cerebrum-and-vs-cerebral-cortex/ >

Histology of Cerebral Cortex

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024757/ Z5177691 (talk) 22:37, 23 August 2017 (AEST)

Early Development of the Brain (and Nervous System)

( Eden )

For concept:

https://www.youtube.com/watch?v=XdN9i_ZWGho

https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Cerebrum_Development

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989000/ https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_Development

Development of Cerebral Cortex

( Anna )

Terminology

  • Corticogenesis:
  • Zones:
    • Ventricular zone
    • Subventricular zone
    • Cortical Plate
    • Preplate: neural progenitor cells split into 2 regions
      • Marginal zone:
      • Subplate:

Timeline

Nature article: https://www.nature.com/nrn/journal/v9/n2/full/nrn2252.html

  • E10.5-- VZ (ventricular zone) single layer of cells- have feet that attach to cerebral wall and start dividing. Slightly polarized.
  • E11.5--cells begin to differentiate (PP/preplate) into “pioneer” neurons and move upward, laying molecular trail for subsequent differentiating neurons
  • E13.5--VZ cells form secondary progenitor population in SVZ, PP (preplate pioneer) cells split into 2 zones (MZ and SP)
    • MZ and SP cells tell newly differentiated and migrating cells where they are
  • E14.5-17.5-- deep layers populated first and then superficial layers later
    • The neuron senses the layer it is in and stops- condense in CP (cortical plate)

6 Layers

Layers I, II, III, IV, V, VI (see "Cortical Layer Review" Z5177691 (talk) 22:57, 23 August 2017 (AEST)


Cell Types

http://www.ruf.rice.edu/~lngbrain/Sidhya/

  • Radial Glial cells--in developing cerebellum, hippocampus, cortex
    • Migrating neurons glump onto radial glial to migrate- move up these RG cells
    • RG Cells for migrating neurons that extend from VZ to get to the outer part of the cortex.
    • Fibers that neurons use to migrate from VZ to their final destination
    • Allows dividing cells (projector neurons)- to migrate not randomly but radially.
    • Radial Glial Cells can divide as well→ overall process requires a lot of membrane

Cell Signaling

Anatomy of the Cerebral Cortex

( Jess)

You might find this helpful (although you need to request copyright permission): "Difference Between Cerebrum and Cerebral Cortex." DifferenceBetween.Com. August 7, 2012. < http://www.differencebetween.com/difference-between-cerebrum-and-vs-cerebral-cortex/ >

Functions of the Cerebral Cortex

( Jess)

For concept:

https://www.youtube.com/watch?v=n6zQbTT0yoY

https://www.youtube.com/watch?v=X-m0JDCw6TE

Abnormalities associated with Cerebral Cortex Development

(Zainab)

(z5093005 )
DRAFT:

Disorders due to abnormal proliferation, growth or differentiation of neuroblasts

Focal cortical dysplasia (FCD)

Hemimegalencephaly

Microcephaly

Tuberous Sclerosis

Disorders due to abnormal neuronal migration

Heterotopia

Subcortical band heterotopia Periventricular heterotopia

Lissencephaly

•undermigration; Classical (Type I) Lisssencephaly

•overmigration;Cobblestone (Type II) lissencephaly

Fragile X-Syndrome

Microlissencephaly

Kallmann Syndrome

Disorders due to abnormal cortical maturation and organization/folding

Polymicrogyria

Schizencephaly

•destructive lesions.

Disorders due to abnormal Integrity of the Pial Surface

Muscle-Eye-Brain Disease

Walker-Warburg

https://www.youtube.com/watch?v=luXDQrmMoUU

Abnormalities- Draft:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992410/
[1]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547618/
[2]

http://www.cell.com/neuron/fulltext/S0896-6273(00)80749-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627300807497%3Fshowall%3Dtrue [3]

https://www.youtube.com/watch?v=l_nTggR7LTE [4]

Corpus Callosum Agenesis

<html5media height="400" width="500">https://www.youtube.com/watch?v=7zOa3LLrHKc</html5media> [5]

Fetal Alcohol Spectrum Disorder (FASD)

Rett Syndrome

Group Discussion Area (temporary heading)

We are supposed to discuss the project here:

https://moodle.telt.unsw.edu.au/mod/hsuforum/view.php?id=1416354

INFO teachers gave (temporary heading)

PubMed Searches: Cerebral Cortex Development | Cerebrum Development

BMC Dev Biol Search: Cerebral Cortex Development

Recent papers

<pubmed limit=5>Cerebral+Cortex+Development</pubmed>

References

[Harvard Style]

  1. Squier, W. and Jansen, A. (2010). Abnormal development of the human cerebral cortex. Journal of Anatomy, [online] 217(4), pp.312-323. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992410/ [Accessed 23 Sep. 2017].
  2. Pang, T., Atefy, R. and Sheen, V. (2008). Malformations of Cortical Development. The Neurologist, [online] 14(3), pp.181-191. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547618/ [Accessed 23 Sep. 2017].
  3. Christopher A, C. (2017). Genetic Malformations of the Human Cerebral Cortex. Neuron, [online] 23(1), pp.19 - 29. Available at: http://www.cell.com/neuron/fulltext/S0896-6273(00)80749-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627300807497%3Fshowall%3Dtrue [Accessed 23 Sep. 2017].
  4. Mahfouz, M. (2015). Imaging of cortical formation disorders - DRE 4 - Prof. Dr Mamdouh Mahfouz. [video] Available at: https://www.youtube.com/watch?v=l_nTggR7LTE [Accessed 23 Sep. 2017].
  5. Ezzo - Izzo, D. (2007). How the Body Works : The Corpus Callosum. [video] Available at: https://www.youtube.com/watch?v=7zOa3LLrHKc [Accessed 23 Sep. 2017].