2017 Group Project 1: Difference between revisions
Line 93: | Line 93: | ||
(Zainab) | (Zainab) | ||
DRAFT: | DRAFT: | ||
Revision as of 22:20, 23 September 2017
2017 Student Projects | |||
---|---|---|---|
|
Cerebral Cortex
Mark Hill (talk) 15:59, 14 September 2017 (AEST) Feedback
- lots of sub-headings, but no actual text.
- no defined structure to the sequence of sub-headings.
- no research images related to what is an extensively researched topic.
- historic background of key research findings, put our understanding today in perspective.
- Lon list of abnormalities, with no description.
Introduction
( Susannah )
What is it?
For concept: https://www.youtube.com/watch?v=dNngOlsLuGI
You might find this helpful (although you need to request copyright permission):
"Difference Between Cerebrum and Cerebral Cortex." DifferenceBetween.Com. August 7, 2012. < http://www.differencebetween.com/difference-between-cerebrum-and-vs-cerebral-cortex/ >
Histology of Cerebral Cortex
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024757/ Z5177691 (talk) 22:37, 23 August 2017 (AEST)
Early Development of the Brain (and Nervous System)
( Eden )
For concept:
https://www.youtube.com/watch?v=XdN9i_ZWGho
https://embryology.med.unsw.edu.au/embryology/index.php/Neural_-_Cerebrum_Development
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989000/ https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_Development
Development of Cerebral Cortex
( Anna )
Terminology
- Corticogenesis:
- Zones:
- Ventricular zone
- Subventricular zone
- Cortical Plate
- Preplate: neural progenitor cells split into 2 regions
- Marginal zone:
- Subplate:
Timeline
Nature article: https://www.nature.com/nrn/journal/v9/n2/full/nrn2252.html
- E10.5-- VZ (ventricular zone) single layer of cells- have feet that attach to cerebral wall and start dividing. Slightly polarized.
- E11.5--cells begin to differentiate (PP/preplate) into “pioneer” neurons and move upward, laying molecular trail for subsequent differentiating neurons
- E13.5--VZ cells form secondary progenitor population in SVZ, PP (preplate pioneer) cells split into 2 zones (MZ and SP)
- MZ and SP cells tell newly differentiated and migrating cells where they are
- E14.5-17.5-- deep layers populated first and then superficial layers later
- The neuron senses the layer it is in and stops- condense in CP (cortical plate)
6 Layers
Layers I, II, III, IV, V, VI (see "Cortical Layer Review" Z5177691 (talk) 22:57, 23 August 2017 (AEST)
Cell Types
http://www.ruf.rice.edu/~lngbrain/Sidhya/
- Radial Glial cells--in developing cerebellum, hippocampus, cortex
- Migrating neurons glump onto radial glial to migrate- move up these RG cells
- RG Cells for migrating neurons that extend from VZ to get to the outer part of the cortex.
- Fibers that neurons use to migrate from VZ to their final destination
- Allows dividing cells (projector neurons)- to migrate not randomly but radially.
- Radial Glial Cells can divide as well→ overall process requires a lot of membrane
Cell Signaling
Anatomy of the Cerebral Cortex
( Jess)
You might find this helpful (although you need to request copyright permission): "Difference Between Cerebrum and Cerebral Cortex." DifferenceBetween.Com. August 7, 2012. < http://www.differencebetween.com/difference-between-cerebrum-and-vs-cerebral-cortex/ >
Functions of the Cerebral Cortex
( Jess)
For concept:
https://www.youtube.com/watch?v=n6zQbTT0yoY
https://www.youtube.com/watch?v=X-m0JDCw6TE
Abnormalities associated with Cerebral Cortex Development
(Zainab)
DRAFT:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992410/
[1]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547618/
[2]
http://www.cell.com/neuron/fulltext/S0896-6273(00)80749-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627300807497%3Fshowall%3Dtrue [3]
https://www.youtube.com/watch?v=l_nTggR7LTE [4]
Disorders due to abnormal proliferation, growth or differentiation of neuroblasts
Focal cortical dysplasia (FCD)
Hemimegalencephaly
Microcephaly
Tuberous Sclerosis
Disorders due to abnormal neuronal migration
Heterotopia
Subcortical band heterotopia Periventricular heterotopia
Lissencephaly
•undermigration; Classical (Type I) Lisssencephaly
•overmigration;Cobblestone (Type II) lissencephaly
Fragile X-Syndrome
Microlissencephaly
Kallmann Syndrome
Disorders due to abnormal cortical maturation and organization/folding
Polymicrogyria
Schizencephaly
•destructive lesions.
Disorders due to abnormal Integrity of the Pial Surface
Muscle-Eye-Brain Disease
Walker-Warburg
https://www.youtube.com/watch?v=luXDQrmMoUU
Corpus Callosum Agenesis
<html5media height="400" width="500">https://www.youtube.com/watch?v=7zOa3LLrHKc</html5media> [5]
Fetal Alcohol Spectrum Disorder (FASD)
Rett Syndrome
Group Discussion Area (temporary heading)
We are supposed to discuss the project here:
https://moodle.telt.unsw.edu.au/mod/hsuforum/view.php?id=1416354
INFO teachers gave (temporary heading)
PubMed Searches: Cerebral Cortex Development | Cerebrum Development
BMC Dev Biol Search: Cerebral Cortex Development
Recent papers
<pubmed limit=5>Cerebral+Cortex+Development</pubmed>
References
[Harvard Style]
- ↑ Squier, W. and Jansen, A. (2010). Abnormal development of the human cerebral cortex. Journal of Anatomy, [online] 217(4), pp.312-323. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992410/ [Accessed 23 Sep. 2017].
- ↑ Pang, T., Atefy, R. and Sheen, V. (2008). Malformations of Cortical Development. The Neurologist, [online] 14(3), pp.181-191. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547618/ [Accessed 23 Sep. 2017].
- ↑ Christopher A, C. (2017). Genetic Malformations of the Human Cerebral Cortex. Neuron, [online] 23(1), pp.19 - 29. Available at: http://www.cell.com/neuron/fulltext/S0896-6273(00)80749-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627300807497%3Fshowall%3Dtrue [Accessed 23 Sep. 2017].
- ↑ Mahfouz, M. (2015). Imaging of cortical formation disorders - DRE 4 - Prof. Dr Mamdouh Mahfouz. [video] Available at: https://www.youtube.com/watch?v=l_nTggR7LTE [Accessed 23 Sep. 2017].
- ↑ Ezzo - Izzo, D. (2007). How the Body Works : The Corpus Callosum. [video] Available at: https://www.youtube.com/watch?v=7zOa3LLrHKc [Accessed 23 Sep. 2017].