2016 Group Project 5

From Embryology
Revision as of 12:02, 14 September 2016 by Z3516832 (talk | contribs)
2016 Student Projects 
Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta
2016 Group Project Topic - Signaling in Development

OK you are now in a group, add a topic with your student signature to the group page.

This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements.
Group Assessment Criteria  
Mark Hill.jpg Science Student Projects
  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of embryology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.
More Information on Assessment Criteria | Science Student Projects

T-box genes and their signalling


The T-box family of transcription factors exhibits widespread involvement throughout development in all metazoans. [1]

PMID 9504043

Features of the T-box family

(Briefly talk about each of the different T-boxs)

Origins of the T-box genes

The story of the T-box genes began in Paris at the Pasteur laboratory in the 1920s with the Russian scientist Nadine Dobrovolskaïa-Zavadskaïa, who embarked on a pioneering screen for X-ray-induced developmental mouse mutants. Her isolation of a mouse strain with a short tail, caused by a semidominant heterozygous mutation in a locus she called T, represented one of the first successful mammalian genetic screens, and provided one of the earliest links between gene activity and cell behaviour during embryogenesis[2]. The mid-gestational death of homozygous T embryos, with perturbed development of the posterior mesoderm and notochord, demonstrated an essential requirement for T during gastrulation, and led to the earliest insights into the inductive influences of notochord on neural tube and somite development. Over 60 years later T, now also known as brachyury, meaning ‘short tail’ in Greek, was cloned in one of the earliest positional cloning efforts in the mouse[3]. At the time, lack of homology in the T-gene product to any previously characterized protein gave no clues as to its biochemical role until, in 1993, it was revealed to be a novel sequence-specific DNA-binding protein[4]. Crystallographic determination of the structure of the DNA-binding domain, now called the Tbox, revealed a new way through which proteins recognize DNA[5].

Functions of T-box in development

(including current research)

Cardiac development

PMID 15580613 PMID 16258075 PMID 1851989

Limb Development

PMID 11782414

PMID 22872086

Respiratory Development

PMID 22876201

Palate Development

PMID 22371266


Z5039628 (talk) 19:37, 1 September 2016 (AEST)


Z5039628 (talk) 23:16, 8 September 2016 (AEST)

PMID 10235264 PMID 18505863 PMID 15066124

Holt-Oram Syndrome primary article PMID 11161571 OMIM 142900

Animal models

Marsupial forelimb development PMID 21098569


  1. <pubmed>25294936</pubmed>
  2. <pubmed>11268043</pubmed>
  3. <pubmed>2154694</pubmed>
  4. <pubmed>8344258</pubmed>
  5. <pubmed>9349824</pubmed>