2016 Group Project 1
From Embryology
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Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta | ||||
2016 Group Project Topic - Signaling in Development
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This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements. |
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Topic: WnT Signaling Pathway in skin of fetus
The signalling pathways:
- Canonical Pathway - Gloria
- The Wnt family of secreted glycolipoproteins play an important role in the role of embryonic development and adult homeostasis.
- They do so via the transcription of β-catenin, which accumulates in the cytoplasm and eventually gets translocated into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family.
- The canonical Wnt pathway of (Wnt/ β-catenin pathway) is the Wnt pathway that causes β-catenin to stay in the cytoplasm rather than be degraded through ubiquitination which is induced by destruction complexes. The destruction complexes which sends β-catenin to proteasome for digestion are proteins such as: Axin, adenomatosis, polyposiscoli (APC), protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α).
- Once the stabilised β-catenin enters the cell nucleus it acts as a transcriptional coactivator for transcription of Wnt-target genes. The primary family of transcription factor which β-catenin associates with is the TCF/LEF family. Activation through β-catenin is mediated with compounds such as histone acetyl transferase CBP, the chromatin-remodeling SWI/SNF complex and Bcl9 bound to pygopus (Pyg).
- This signalling pathway is crucial for deciding the fate of cells during early embryogenesis.
<pubmed>19279717 </pubmed>
- Non-Canonical Pathway - Caroline
- WnT-Calcium Ion Pathway - Tony
How does it work in a foetus (skin formation) - Arsalan
What can go wrong?
Wnt-Calcium Ion Pathway
References
PMID 21903638